AU2019419494B2 - DUX4 RNA silencing using RNA targeting CRISPR-Cas13b - Google Patents

DUX4 RNA silencing using RNA targeting CRISPR-Cas13b

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Publication number
AU2019419494B2
AU2019419494B2 AU2019419494A AU2019419494A AU2019419494B2 AU 2019419494 B2 AU2019419494 B2 AU 2019419494B2 AU 2019419494 A AU2019419494 A AU 2019419494A AU 2019419494 A AU2019419494 A AU 2019419494A AU 2019419494 B2 AU2019419494 B2 AU 2019419494B2
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dux4
seq
nucleic acid
nucleotide sequence
cas13
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AU2019419494A
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AU2019419494A1 (en
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Scott Quenton HARPER
Afrooz RASHNONEJAD
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Nationwide Childrens Hospital Inc
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Nationwide Childrens Hospital Inc
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2750/14011—Parvoviridae
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

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AU2019419494A 2018-12-31 2019-12-31 DUX4 RNA silencing using RNA targeting CRISPR-Cas13b Active AU2019419494B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862786670P 2018-12-31 2018-12-31
US62/786,670 2018-12-31
PCT/US2019/069048 WO2020142479A1 (en) 2018-12-31 2019-12-31 Dux4 rna silencing using rna targeting crispr-cas13b

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AU2019419494A1 AU2019419494A1 (en) 2021-07-15
AU2019419494B2 true AU2019419494B2 (en) 2026-03-26

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US (1) US12545909B2 (https=)
EP (1) EP3906308A1 (https=)
JP (2) JP2022516515A (https=)
KR (1) KR20210110345A (https=)
AU (1) AU2019419494B2 (https=)
CA (1) CA3124963A1 (https=)
IL (1) IL284447B2 (https=)
WO (1) WO2020142479A1 (https=)

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WO2021113270A1 (en) 2019-12-02 2021-06-10 Shape Therapeutics Inc. Therapeutic editing
WO2021142267A1 (en) 2020-01-08 2021-07-15 Scarpmap Llc Methods and computing system for processing ultrasound image to determine health of subdermal tissue
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JP2022516515A (ja) 2022-02-28
EP3906308A1 (en) 2021-11-10
US20220106592A1 (en) 2022-04-07
WO2020142479A1 (en) 2020-07-09
KR20210110345A (ko) 2021-09-07
AU2019419494A1 (en) 2021-07-15
IL284447A (en) 2021-08-31
CA3124963A1 (en) 2020-07-09
JP2025032342A (ja) 2025-03-11
US12545909B2 (en) 2026-02-10
IL284447B1 (en) 2025-12-01
IL284447B2 (en) 2026-04-01

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