AU2019395341B2 - Chemically-modified RNAi constructs and uses thereof - Google Patents

Chemically-modified RNAi constructs and uses thereof

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Publication number
AU2019395341B2
AU2019395341B2 AU2019395341A AU2019395341A AU2019395341B2 AU 2019395341 B2 AU2019395341 B2 AU 2019395341B2 AU 2019395341 A AU2019395341 A AU 2019395341A AU 2019395341 A AU2019395341 A AU 2019395341A AU 2019395341 B2 AU2019395341 B2 AU 2019395341B2
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Prior art keywords
modified nucleotide
nucleotides
nucleotide
rnai construct
antisense strand
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AU2019395341A
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AU2019395341A1 (en
Inventor
Yuan Cheng
Bradley J. Herberich
Justin K. Murray
Bin Wu
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Amgen Inc
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Amgen Inc
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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AU2019395341A 2018-12-10 2019-12-09 Chemically-modified RNAi constructs and uses thereof Active AU2019395341B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862777677P 2018-12-10 2018-12-10
US62/777,677 2018-12-10
PCT/US2019/065294 WO2020123410A1 (en) 2018-12-10 2019-12-09 CHEMICALLY-MODIFIED RNAi CONSTRUCTS AND USES THEREOF

Publications (2)

Publication Number Publication Date
AU2019395341A1 AU2019395341A1 (en) 2021-06-17
AU2019395341B2 true AU2019395341B2 (en) 2026-04-23

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US (1) US20220049252A1 (https=)
EP (1) EP3894554A1 (https=)
JP (1) JP7814932B2 (https=)
KR (1) KR20210102313A (https=)
CN (2) CN113166759B (https=)
AU (1) AU2019395341B2 (https=)
BR (1) BR112021011043A2 (https=)
CA (1) CA3122393A1 (https=)
CL (1) CL2021001490A1 (https=)
EA (1) EA202191630A1 (https=)
IL (1) IL283550A (https=)
MX (1) MX2021006745A (https=)
SG (1) SG11202105900UA (https=)
WO (1) WO2020123410A1 (https=)

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WO2024140101A1 (zh) * 2022-12-28 2024-07-04 北京炫景瑞医药科技有限公司 修饰的双链寡核苷酸分子、修饰的双链寡核苷酸缀合物及其用途
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