JP7814932B2 - 化学修飾されたＲＮＡｉコンストラクト及びその使用 - Google Patents

化学修飾されたＲＮＡｉコンストラクト及びその使用

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JP7814932B2
JP7814932B2 JP2021532219A JP2021532219A JP7814932B2 JP 7814932 B2 JP7814932 B2 JP 7814932B2 JP 2021532219 A JP2021532219 A JP 2021532219A JP 2021532219 A JP2021532219 A JP 2021532219A JP 7814932 B2 JP7814932 B2 JP 7814932B2
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nucleotides
nucleotide
rnai construct
antisense strand
positions
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JP2022511866A (ja
JP2022511866A5 (https=
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マレー，ジャスティン・ケイ
ウー，ビン
チュヨン，ユエン
ハーバリッチ，ブラッドリー・ジェイ
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アムジエン・インコーポレーテツド
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2021532219A 2018-12-10 2019-12-09 化学修飾されたＲＮＡｉコンストラクト及びその使用 Active JP7814932B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862777677P 2018-12-10 2018-12-10
US62/777,677 2018-12-10
PCT/US2019/065294 WO2020123410A1 (en) 2018-12-10 2019-12-09 CHEMICALLY-MODIFIED RNAi CONSTRUCTS AND USES THEREOF

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JP2026017347A Division JP2026074186A (ja) 2018-12-10 2026-02-04 化学修飾されたＲＮＡｉコンストラクト及びその使用

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JP2022511866A JP2022511866A (ja) 2022-02-01
JP2022511866A5 JP2022511866A5 (https=) 2022-12-14
JP7814932B2 true JP7814932B2 (ja) 2026-02-17

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US (1) US20220049252A1 (https=)
EP (1) EP3894554A1 (https=)
JP (1) JP7814932B2 (https=)
KR (1) KR20210102313A (https=)
CN (2) CN113166759B (https=)
AU (1) AU2019395341B2 (https=)
BR (1) BR112021011043A2 (https=)
CA (1) CA3122393A1 (https=)
CL (1) CL2021001490A1 (https=)
EA (1) EA202191630A1 (https=)
IL (1) IL283550A (https=)
MX (1) MX2021006745A (https=)
SG (1) SG11202105900UA (https=)
WO (1) WO2020123410A1 (https=)

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AU2019398101B2 (en) 2018-12-10 2025-12-18 Amgen Inc. Mutated piggybac transposase
MX2022007005A (es) * 2019-12-09 2022-08-25 Amgen Inc Construcciones de iarn y metodos para inhibir la expresion de lpa.
KR20240004092A (ko) * 2020-06-01 2024-01-11 암젠 인크 Hsd17b13 발현을 억제하기 위한 rnai 작제물 및 이의 사용 방법
KR20230046319A (ko) 2020-08-13 2023-04-05 암젠 인크 MARC1 발현을 억제하기 위한 RNAi 작제물 및 방법
AU2021373780A1 (en) * 2020-11-05 2023-06-08 Amgen Inc. METHODS FOR TREATING ATHEROSCLEROTIC CARDIOVASCULAR DISEASE WITH LPA-TARGETED RNAi CONSTRUCTS
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EP4294449A1 (en) * 2021-02-18 2023-12-27 Oneglobe Holdings Limited Compositions for conjugating oligonucleotides and carbohydrates
CA3225054A1 (en) * 2021-07-08 2023-02-12 Sun Woo Hong Rnai agent targeting marc1 gene, and use thereof
IL312811A (en) 2021-11-16 2024-07-01 Shanghai Argo Biopharmaceutical Co Ltd Composition and method for inhibiting angiotensinogen (agt) protein expression
CN114703184B (zh) * 2022-03-11 2024-06-18 厦门甘宝利生物医药有限公司 Lpa抑制剂及其用途
WO2023207615A1 (zh) * 2022-04-26 2023-11-02 南京明德新药研发有限公司 一类含由天然核苷酸组成突出端的双链RNAi化合物
US20240084301A1 (en) 2022-07-25 2024-03-14 Amgen Inc. Rnai constructs and methods for inhibiting fam13a expression
CN120615125A (zh) * 2022-07-27 2025-09-09 e-生物有限公司 核酸化合物
AU2023313030A1 (en) * 2022-07-27 2025-01-09 E-Therapeutics Plc Nucleic acid compounds
IL319076A (en) * 2022-09-20 2025-04-01 Shanghai Argo Biopharmaceutical Co Ltd A defined modified RNAi factor and its composition
KR20250088573A (ko) * 2022-10-14 2025-06-17 사네진 바이오 유에스에이 인크. C3을 표적화하는 소형 간섭 rna 및 그의 용도
WO2024140101A1 (zh) * 2022-12-28 2024-07-04 北京炫景瑞医药科技有限公司 修饰的双链寡核苷酸分子、修饰的双链寡核苷酸缀合物及其用途
TW202509024A (zh) 2023-05-19 2025-03-01 大陸商深圳信立泰藥業股份有限公司 一種磺醯胺類化合物及其製備方法和醫藥用途
CN119343449A (zh) * 2023-05-24 2025-01-21 云合智药（苏州）生物科技有限公司 用于抑制angptl3表达的rnai剂及其应用
WO2025113470A1 (en) * 2023-11-27 2025-06-05 Shanghai Argo Biopharmaceutical Co., Ltd. Compositions and methods for inhibiting expression of transthyretin (ttr)
WO2025232837A1 (zh) * 2024-05-08 2025-11-13 深圳信立泰药业股份有限公司 经修饰的siRNA及其制备方法和用途
WO2025260042A1 (en) 2024-06-14 2025-12-18 Amgen Inc. Rnai constructs and methods for inhibiting cnr1 expression
WO2026002138A1 (zh) * 2024-06-27 2026-01-02 成都新泽利医药科技有限公司 特定修饰的双链寡核苷酸及其组合物

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