AU2019379808C1 - Inhibitors of ARG1 and/or ARG2 - Google Patents
Inhibitors of ARG1 and/or ARG2 Download PDFInfo
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- AU2019379808C1 AU2019379808C1 AU2019379808A AU2019379808A AU2019379808C1 AU 2019379808 C1 AU2019379808 C1 AU 2019379808C1 AU 2019379808 A AU2019379808 A AU 2019379808A AU 2019379808 A AU2019379808 A AU 2019379808A AU 2019379808 C1 AU2019379808 C1 AU 2019379808C1
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- ARAIBEBZBOPLMB-UFGQHTETSA-N zanamivir Chemical compound CC(=O)N[C@@H]1[C@@H](N=C(N)N)C=C(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO ARAIBEBZBOPLMB-UFGQHTETSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
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- A—HUMAN NECESSITIES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
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- A—HUMAN NECESSITIES
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| PCT/US2019/061657 WO2020102646A2 (en) | 2018-11-16 | 2019-11-15 | Inhibitors of arg1 and/or arg2 |
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| US (1) | US20220016143A1 (zh) |
| EP (1) | EP3880685A4 (zh) |
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| MX2022011534A (es) | 2020-03-19 | 2022-10-13 | Arcus Biosciences Inc | Compuestos de tetralina y tetrahidroquinolina como inhibidores de hif-2alfa. |
| PE20231078A1 (es) | 2020-06-02 | 2023-07-17 | Arcus Biosciences Inc | Anticuerpos anti-tigit |
| JP2023530456A (ja) | 2020-06-17 | 2023-07-18 | アーカス バイオサイエンシズ インコーポレイティド | Ｃｄ７３阻害剤の結晶形態及びその使用 |
| TW202228720A (zh) | 2020-12-22 | 2022-08-01 | 波蘭商昂科艾倫迪治療法股份公司 | 精胺酸酶抑制劑及其使用方法 |
| JP2024521706A (ja) | 2021-05-21 | 2024-06-04 | アーカス バイオサイエンシーズ，インコーポレーテッド | Ａｘｌ化合物 |
| WO2022246179A1 (en) | 2021-05-21 | 2022-11-24 | Arcus Biosciences, Inc. | Axl inhibitor compounds |
| US20230159466A1 (en) | 2021-10-29 | 2023-05-25 | Arcus Biosciences, Inc. | Inhibitors of hif-2alpha and methods of use thereof |
| TW202409083A (zh) | 2022-05-02 | 2024-03-01 | 美商阿克思生物科學有限公司 | 抗-tigit抗體及其用途 |
| WO2024015251A1 (en) | 2022-07-15 | 2024-01-18 | Arcus Biosciences, Inc. | Inhibitors of hpk1 and methods of use thereof |
| WO2024020034A1 (en) | 2022-07-20 | 2024-01-25 | Arcus Biosciences, Inc. | Cbl-b inhibitors and methods of use thereof |
| WO2024059142A1 (en) | 2022-09-14 | 2024-03-21 | Arcus Biosciences, Inc. | Dispersions of etrumadenant |
| WO2024081385A1 (en) | 2022-10-14 | 2024-04-18 | Arcus Biosciences, Inc. | Hpk1 inhibitors and methods of use thereof |
| WO2024086718A1 (en) | 2022-10-20 | 2024-04-25 | Arcus Biosciences, Inc. | Lyophilized formulations of cd73 compounds |
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| WO2019245890A1 (en) * | 2018-06-20 | 2019-12-26 | Merck Sharp & Dohme Corp. | Arginase inhibitors and methods of use |
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| RU2557290C2 (ru) * | 2009-09-25 | 2015-07-20 | Шайр Орфан Терапис ГмбХ | Новые агонисты npr-b |
| CN104876955B (zh) | 2010-04-22 | 2018-11-23 | 马尔斯公司 | 精氨酸酶抑制剂及其治疗应用 |
| ES2568680T3 (es) * | 2010-10-26 | 2016-05-03 | Mars, Incorporated | Boratos como inhibidores de arginasa |
| WO2013158262A1 (en) * | 2012-04-18 | 2013-10-24 | Mars, Incorporated | Ring constrained analogs as arginase inhibitors |
| PL410665A1 (pl) * | 2014-12-29 | 2016-07-04 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Inhibitory arginazy oraz ich zastosowania terapeutyczne |
| US10143699B2 (en) * | 2015-06-23 | 2018-12-04 | Calithera Biosciences, Inc. | Compositions and methods for inhibiting arginase activity |
| EP3490581A4 (en) | 2016-07-26 | 2020-10-14 | Flagship Pioneering Innovations V, Inc. | NEUROMODULATING COMPOSITIONS AND RELATED THERAPEUTIC PROCEDURES FOR TREATMENT OF CANCER |
| WO2018089490A1 (en) * | 2016-11-08 | 2018-05-17 | Calithera Biosciences, Inc. | Arginase inhibitor combination therapies |
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| WO2020102646A2 (en) | 2020-05-22 |
| UY38476A (es) | 2020-06-30 |
| EP3880685A2 (en) | 2021-09-22 |
| CN113382998A (zh) | 2021-09-10 |
| JP7461350B2 (ja) | 2024-04-03 |
| AU2019379808A1 (en) | 2021-06-24 |
| AR117102A1 (es) | 2021-07-14 |
| KR20210108954A (ko) | 2021-09-03 |
| US20220016143A1 (en) | 2022-01-20 |
| TW202033203A (zh) | 2020-09-16 |
| CA3120196A1 (en) | 2020-05-22 |
| AU2019379808B2 (en) | 2023-08-03 |
| JP2022507474A (ja) | 2022-01-18 |
| TWI828800B (zh) | 2024-01-11 |
| WO2020102646A3 (en) | 2020-08-13 |
| EP3880685A4 (en) | 2022-07-27 |
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