AU2019374812B2 - Pyridazinone compounds and uses thereof - Google Patents
Pyridazinone compounds and uses thereof Download PDFInfo
- Publication number
- AU2019374812B2 AU2019374812B2 AU2019374812A AU2019374812A AU2019374812B2 AU 2019374812 B2 AU2019374812 B2 AU 2019374812B2 AU 2019374812 A AU2019374812 A AU 2019374812A AU 2019374812 A AU2019374812 A AU 2019374812A AU 2019374812 B2 AU2019374812 B2 AU 2019374812B2
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- independently selected
- optionally substituted
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- rio
- alkyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862756552P | 2018-11-06 | 2018-11-06 | |
| US62/756,552 | 2018-11-06 | ||
| PCT/US2019/060148 WO2020097258A1 (en) | 2018-11-06 | 2019-11-06 | Pyridazinone compounds and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2019374812A1 AU2019374812A1 (en) | 2021-06-10 |
| AU2019374812B2 true AU2019374812B2 (en) | 2025-03-06 |
Family
ID=69326619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2019374812A Active AU2019374812B2 (en) | 2018-11-06 | 2019-11-06 | Pyridazinone compounds and uses thereof |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11390606B2 (https=) |
| EP (1) | EP3877367B1 (https=) |
| JP (2) | JP7671245B2 (https=) |
| CN (1) | CN113272280B (https=) |
| AU (1) | AU2019374812B2 (https=) |
| CA (1) | CA3118904A1 (https=) |
| WO (1) | WO2020097258A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021514010A (ja) * | 2018-02-20 | 2021-06-03 | エッジワイズ セラピューティクス， インコーポレイテッド | 運動障害を処置するための方法および組成物 |
| WO2020097258A1 (en) | 2018-11-06 | 2020-05-14 | Edgewise Therapeutics, Inc. | Pyridazinone compounds and uses thereof |
| ES2958954T3 (es) * | 2018-11-06 | 2024-02-16 | Edgewise Therapeutics Inc | Compuestos de piridazinona y usos de los mismos |
| EP3877052B1 (en) | 2018-11-06 | 2023-08-16 | Edgewise Therapeutics, Inc. | Pyridazinone compounds and uses thereof |
| IL285067B2 (en) | 2019-01-22 | 2025-02-01 | Aeovian Pharmaceuticals Inc | MTORC Modulators and Their Uses |
| JP7758687B2 (ja) * | 2020-05-13 | 2025-10-22 | エッジワイズ セラピューティクス， インコーポレイテッド | 神経筋疾患の処置のためのピリダジノン化合物 |
| WO2021231546A1 (en) * | 2020-05-13 | 2021-11-18 | Edgewise Therapeutics, Inc. | Substituted pyridazinone for use in the treatment of neuromuscular diseases |
| WO2021231615A1 (en) * | 2020-05-13 | 2021-11-18 | Edgewise Therapeutics, Inc. | Substituted pyridazinone for use in the treatment of neuromuscular diseases |
| WO2021231630A1 (en) * | 2020-05-13 | 2021-11-18 | Edgewise Therapeutics, Inc. | Substituted pyridazinone for use in the treatment of neuromuscular diseases |
| EP4149620B1 (en) * | 2020-05-13 | 2024-10-23 | Edgewise Therapeutics, Inc. | Pyridazinone compounds for the treatment of neuromuscular diseases |
| JP2025530218A (ja) | 2022-09-09 | 2025-09-11 | エッジワイズ セラピューティクス， インコーポレイテッド | 神経筋の状態の処置のためのピリダジノン組成物 |
| JP2026501712A (ja) * | 2023-01-04 | 2026-01-16 | シーザン ハイスーク ファーマシューティカル カンパニー リミテッド | ピリダジノンヘテロ環化合物Ｍｙｏｓｉｎ ＩＩ阻害剤及びその用途 |
| WO2025167826A1 (zh) * | 2024-02-06 | 2025-08-14 | 西藏海思科制药有限公司 | 三环化合物作为Myosin II抑制剂及其用途 |
Citations (5)
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| US20060189621A1 (en) * | 2003-03-07 | 2006-08-24 | Seiichi Sato | Benzofuran derivative |
| WO2009006959A1 (de) * | 2007-07-12 | 2009-01-15 | Merck Patent Gmbh | Pyridazinonderivate |
| WO2014096965A2 (en) * | 2012-12-21 | 2014-06-26 | Rvx Therapeutics Inc. | Novel heterocyclic compounds as bromodomain inhibitors |
| US20150376167A1 (en) * | 2013-02-07 | 2015-12-31 | Merck Patent Gmbh | Pyridazinone-amides derivatives |
| JP2025040270A (ja) * | 2023-09-11 | 2025-03-24 | 共同印刷株式会社 | 赤外線遮断性生地 |
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| JPS6140270A (ja) | 1984-08-01 | 1986-02-26 | Morishita Seiyaku Kk | ピリダジノン誘導体 |
| DD286354A5 (de) | 1989-08-08 | 1991-01-24 | Karl-Marx-Universitaet Leipzig,De | Verfahren zur herstellung substituierter 2-carbamoyl-methyl-4-phenyl-1,2,5,6-tetrahydro- und 1,2-dihydro-1-oxo-pyridazine |
| DE69131268T2 (de) | 1990-09-21 | 1999-12-30 | Rohm And Haas Co., Philadelphia | Dihydropyridazinone und Pyridazinone als Fungizide |
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| WO2020097258A1 (en) | 2018-11-06 | 2020-05-14 | Edgewise Therapeutics, Inc. | Pyridazinone compounds and uses thereof |
| EP3877052B1 (en) | 2018-11-06 | 2023-08-16 | Edgewise Therapeutics, Inc. | Pyridazinone compounds and uses thereof |
| WO2021231615A1 (en) | 2020-05-13 | 2021-11-18 | Edgewise Therapeutics, Inc. | Substituted pyridazinone for use in the treatment of neuromuscular diseases |
| WO2021231546A1 (en) | 2020-05-13 | 2021-11-18 | Edgewise Therapeutics, Inc. | Substituted pyridazinone for use in the treatment of neuromuscular diseases |
| WO2021231630A1 (en) | 2020-05-13 | 2021-11-18 | Edgewise Therapeutics, Inc. | Substituted pyridazinone for use in the treatment of neuromuscular diseases |
| EP4149620B1 (en) | 2020-05-13 | 2024-10-23 | Edgewise Therapeutics, Inc. | Pyridazinone compounds for the treatment of neuromuscular diseases |
| JP7758687B2 (ja) | 2020-05-13 | 2025-10-22 | エッジワイズ セラピューティクス， インコーポレイテッド | 神経筋疾患の処置のためのピリダジノン化合物 |
| JP7694135B2 (ja) | 2021-05-11 | 2025-06-18 | 株式会社大林組 | 接続構造及び接続方法 |
| EP4433473A1 (en) | 2021-11-17 | 2024-09-25 | Edgewise Therapeutics, Inc. | Pyridazinone compounds and uses thereof |
| EP4522599A1 (en) | 2022-05-11 | 2025-03-19 | Edgewise Therapeutics, Inc. | Methods of manufacturing pyridazinone compounds |
| JP2025530218A (ja) | 2022-09-09 | 2025-09-11 | エッジワイズ セラピューティクス， インコーポレイテッド | 神経筋の状態の処置のためのピリダジノン組成物 |
-
2019
- 2019-11-06 WO PCT/US2019/060148 patent/WO2020097258A1/en not_active Ceased
- 2019-11-06 CA CA3118904A patent/CA3118904A1/en active Pending
- 2019-11-06 CN CN201980088112.8A patent/CN113272280B/zh active Active
- 2019-11-06 EP EP19842909.4A patent/EP3877367B1/en active Active
- 2019-11-06 JP JP2021524226A patent/JP7671245B2/ja active Active
- 2019-11-06 AU AU2019374812A patent/AU2019374812B2/en active Active
-
2020
- 2020-11-03 US US17/088,468 patent/US11390606B2/en active Active
-
2022
- 2022-05-27 US US17/827,547 patent/US12240833B2/en active Active
-
2024
- 2024-12-23 JP JP2024226318A patent/JP2025041790A/ja active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CAS registry number: 922867-00-3: Date entered STN: 23 Feb 2007; Chemical name: 2-[(2,4-dichlorophenyl)methyl]-6-[4-(1-piperidinyl)phenyl]-3(2H)-pyridazinone * |
| CAS registry number: 922867-06-9; Date entered STN: 23 Feb 2007; Chemical name: 2-[(3,4-dichlorophenyl)methyl]-6-[4-(1-piperidinyl)phenyl]-3(2H)-pyridazinone * |
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| CAS registry number: 922935-77-1; Date entered STN: 23 Feb 2007; Chemical name: 6-[4-(1-piperidinyl)phenyl]-2-[[3-(trifluoromethyl)phenyl]methyl]-3(2H)-pyridazinone * |
| CAS registry number: 922935-98-6; Date entered STN: 23 Feb 2007; Chemical name: 2-[(4-chlorophenyl)methyl]-6-[4-(1-piperidinyl)phenyl]-3(2H)-pyridazinone * |
| CAS registry number: 922980-68-5; Date entered STN: 23 Feb 2007; Chemical name: 2-[(2-fluorophenyl)methyl]-6-[4-(1-piperidinyl)phenyl]-3(2H)-pyridazinone * |
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Also Published As
| Publication number | Publication date |
|---|---|
| JP7671245B2 (ja) | 2025-05-01 |
| US20210130327A1 (en) | 2021-05-06 |
| JP2022506686A (ja) | 2022-01-17 |
| EP3877367A1 (en) | 2021-09-15 |
| JP2025041790A (ja) | 2025-03-26 |
| CA3118904A1 (en) | 2020-05-14 |
| CN113272280B (zh) | 2026-01-09 |
| AU2019374812A1 (en) | 2021-06-10 |
| CN113272280A (zh) | 2021-08-17 |
| US11390606B2 (en) | 2022-07-19 |
| EP3877367B1 (en) | 2024-05-22 |
| WO2020097258A1 (en) | 2020-05-14 |
| US20230048816A1 (en) | 2023-02-16 |
| US12240833B2 (en) | 2025-03-04 |
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