AU2019374812B2 - Pyridazinone compounds and uses thereof - Google Patents

Pyridazinone compounds and uses thereof Download PDF

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AU2019374812B2
AU2019374812B2 AU2019374812A AU2019374812A AU2019374812B2 AU 2019374812 B2 AU2019374812 B2 AU 2019374812B2 AU 2019374812 A AU2019374812 A AU 2019374812A AU 2019374812 A AU2019374812 A AU 2019374812A AU 2019374812 B2 AU2019374812 B2 AU 2019374812B2
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independently selected
optionally substituted
halogen
rio
alkyl
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AU2019374812A1 (en
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Kevin Hunt
Kevin Koch
Alan Russell
Stephen Schlachter
Chris Steele
Grace UZOHO
Paul WINSHIP
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Edgewise Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2019374812A 2018-11-06 2019-11-06 Pyridazinone compounds and uses thereof Active AU2019374812B2 (en)

Applications Claiming Priority (3)

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US201862756552P 2018-11-06 2018-11-06
US62/756,552 2018-11-06
PCT/US2019/060148 WO2020097258A1 (en) 2018-11-06 2019-11-06 Pyridazinone compounds and uses thereof

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AU2019374812A1 AU2019374812A1 (en) 2021-06-10
AU2019374812B2 true AU2019374812B2 (en) 2025-03-06

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US (2) US11390606B2 (enExample)
EP (1) EP3877367B1 (enExample)
JP (2) JP7671245B2 (enExample)
CN (1) CN113272280B (enExample)
AU (1) AU2019374812B2 (enExample)
CA (1) CA3118904A1 (enExample)
WO (1) WO2020097258A1 (enExample)

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EP3755352A4 (en) * 2018-02-20 2021-12-22 Edgewise Therapeutics, Inc. METHODS AND COMPOSITIONS FOR THE TREATMENT OF MOTION DISORDERS
KR102885525B1 (ko) 2018-11-06 2025-11-13 엣지와이즈 테라퓨틱스, 인크. 피리다지논 화합물 및 이의 용도
WO2020097258A1 (en) 2018-11-06 2020-05-14 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof
SMT202300355T1 (it) 2018-11-06 2024-01-10 Edgewise Therapeutics Inc Composti di piridazinone e loro usi
CA3127448C (en) 2019-01-22 2024-06-04 Aeovian Pharmaceuticals, Inc. Mtorc modulators and uses thereof
WO2021231572A1 (en) * 2020-05-13 2021-11-18 Edgewise Therapeutics, Inc. Pyridazinone compounds for the treatment of neuromuscular diseases
EP4149467A1 (en) * 2020-05-13 2023-03-22 Edgewise Therapeutics, Inc. Substituted pyridazinone for use in the treatment of neuromuscular diseases
EP4149465A1 (en) * 2020-05-13 2023-03-22 Edgewise Therapeutics, Inc. Substituted pyridazinone for use in the treatment of neuromuscular diseases
EP4473968A3 (en) * 2020-05-13 2025-03-26 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof
WO2021231630A1 (en) * 2020-05-13 2021-11-18 Edgewise Therapeutics, Inc. Substituted pyridazinone for use in the treatment of neuromuscular diseases
JP2025530218A (ja) 2022-09-09 2025-09-11 エッジワイズ セラピューティクス， インコーポレイテッド 神経筋の状態の処置のためのピリダジノン組成物
EP4647429A1 (en) 2023-01-04 2025-11-12 Xizang Haisco Pharmaceutical Co., Ltd. Pyridazinone heterocyclic compound myosin ii inhibitor and use thereof
WO2025167826A1 (zh) * 2024-02-06 2025-08-14 西藏海思科制药有限公司 三环化合物作为Myosin II抑制剂及其用途

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CAS registry number: 922935-15-7; Date entered STN: 23 Feb 2007; Chemical name: 2-[(3-fluorophenyl)methyl]-6-[4-(1-piperidinyl)phenyl]-3(2H)-pyridazinone *
CAS registry number: 922935-69-1; Date entered STN: 23 Feb 2007; Chemical name: 2-[(2-methylphenyl)methyl]-6-[4-(1-piperidinyl)phenyl]-3(2H)-pyridazinone *
CAS registry number: 922935-77-1; Date entered STN: 23 Feb 2007; Chemical name: 6-[4-(1-piperidinyl)phenyl]-2-[[3-(trifluoromethyl)phenyl]methyl]-3(2H)-pyridazinone *
CAS registry number: 922935-98-6; Date entered STN: 23 Feb 2007; Chemical name: 2-[(4-chlorophenyl)methyl]-6-[4-(1-piperidinyl)phenyl]-3(2H)-pyridazinone *
CAS registry number: 922980-68-5; Date entered STN: 23 Feb 2007; Chemical name: 2-[(2-fluorophenyl)methyl]-6-[4-(1-piperidinyl)phenyl]-3(2H)-pyridazinone *
CAS registry number: 922981-23-5; Date entered STN: 23 Feb 2007; Chemical name: 2-[(3-nitrophenyl)methyl]-6-[4-(1-piperidinyl)phenyl]-3(2H)-pyridazinone *
CAS registry number: 922981-25-7; Date entered STN: 23 Feb 2007; Chemical name: 6-[4-(1-piperidinyl)phenyl]-2-[[4-(trifluoromethyl)phenyl]methyl]-3(2H)-pyridazinone *
CAS registry number: 922981-41-7; Date entered STN: 23 Feb 2007; Chemical name: 2-[(2-chlorophenyl)methyl]-6-[4-(1-piperidinyl)phenyl]-3(2H)-pyridazinone *
CAS registry number: 922981-44-0; Date entered STN: 23 Feb 2007; Chemical name: 2-[(3-chlorophenyl)methyl]-6-[4-(1-piperidinyl)phenyl]-3(2H)-pyridazinone *
CAS registry number: 923063-37-0; Date entered STN: 26 Feb 2007; Chemical name: 2-[(3-methylphenyl)methyl]-6-[4-(1-piperidinyl)phenyl]-3(2H)-pyridazinone *
CAS registry number: 923063-76-7; Date entered STN: 26 Feb 2007; Chemical name: 2-[(4-methylphenyl)methyl]-6-[4-(1-piperidinyl)phenyl]-3(2H)-pyridazinone *
CAS registry number: 923063-82-5; Date entered STN: 26 Feb 2007; Chemical name: 2-[(4-bromophenyl)methyl]-6-[4-(1-piperidinyl)phenyl]-3(2H)-pyridazinone *
CAS registry number: 923063-90-5; Date entered STN: 26 Feb 2007; Chemical name: 2-[(4-nitrophenyl)methyl]-6-[4-(1-piperidinyl)phenyl]-3(2H)-pyridazinone *
CAS registry number: 923063-98-3; Date entered STN: 26 Feb 2007; Chemical name: 2-[(2-chloro-6-fluorophenyl)methyl]-6-[4-(1-piperidinyl)phenyl]-3(2H)-pyridazinone *

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EP3877367A1 (en) 2021-09-15
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JP7671245B2 (ja) 2025-05-01
AU2019374812A1 (en) 2021-06-10
WO2020097258A1 (en) 2020-05-14
US12240833B2 (en) 2025-03-04
CA3118904A1 (en) 2020-05-14
EP3877367B1 (en) 2024-05-22
US20210130327A1 (en) 2021-05-06
CN113272280A (zh) 2021-08-17
US20230048816A1 (en) 2023-02-16
CN113272280B (zh) 2026-01-09

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