AU2019374523A1 - Anti-PTK7 immune cell cancer therapy - Google Patents
Anti-PTK7 immune cell cancer therapy Download PDFInfo
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- AU2019374523A1 AU2019374523A1 AU2019374523A AU2019374523A AU2019374523A1 AU 2019374523 A1 AU2019374523 A1 AU 2019374523A1 AU 2019374523 A AU2019374523 A AU 2019374523A AU 2019374523 A AU2019374523 A AU 2019374523A AU 2019374523 A1 AU2019374523 A1 AU 2019374523A1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/421—Immunoglobulin superfamily
- A61K40/4211—CD19 or B4
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- A61K40/4251—Kinases, e.g. Raf or Src
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- A61P35/00—Antineoplastic agents
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- A61K2239/49—Breast
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- A—HUMAN NECESSITIES
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/54—Pancreas
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/55—Lung
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- A—HUMAN NECESSITIES
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C07K2319/00—Fusion polypeptide
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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- Immunology (AREA)
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- Public Health (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
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- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
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- Plant Pathology (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Developmental Biology & Embryology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862756638P | 2018-11-07 | 2018-11-07 | |
| US62/756,638 | 2018-11-07 | ||
| US201962910586P | 2019-10-04 | 2019-10-04 | |
| US62/910,586 | 2019-10-04 | ||
| PCT/IB2019/059585 WO2020095248A1 (en) | 2018-11-07 | 2019-11-07 | Anti-ptk7 immune cell cancer therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2019374523A1 true AU2019374523A1 (en) | 2021-05-20 |
Family
ID=68582072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2019374523A Withdrawn AU2019374523A1 (en) | 2018-11-07 | 2019-11-07 | Anti-PTK7 immune cell cancer therapy |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20210290678A1 (https=) |
| EP (1) | EP3877421A1 (https=) |
| JP (2) | JP2022509017A (https=) |
| KR (1) | KR20210092236A (https=) |
| CN (1) | CN112955472A (https=) |
| AU (1) | AU2019374523A1 (https=) |
| BR (1) | BR112021008083A2 (https=) |
| CA (1) | CA3118830A1 (https=) |
| CO (1) | CO2021005471A2 (https=) |
| IL (1) | IL282532A (https=) |
| MX (1) | MX2021005400A (https=) |
| PH (1) | PH12021551047A1 (https=) |
| SG (1) | SG11202104631SA (https=) |
| WO (1) | WO2020095248A1 (https=) |
| ZA (1) | ZA202102745B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115894696A (zh) * | 2021-08-18 | 2023-04-04 | 和迈生物科技有限公司 | 抗ptk7单域抗体及其应用 |
| WO2023084399A1 (en) * | 2021-11-09 | 2023-05-19 | Crispr Therapeutics Ag | Genetically engineered immune cells expressing masked chimeric antigen receptors specific to protein tyrosine kinase 7 |
| IL315366A (en) * | 2022-03-23 | 2024-11-01 | Synaffix Bv | Antibody pairs for targeting PTK7-expressing tumors |
| AU2023272589A1 (en) * | 2022-05-17 | 2025-01-09 | Arsenal Biosciences, Inc. | Systems of engineered receptors targeting psma and ca9 |
| US20260078201A1 (en) * | 2022-09-06 | 2026-03-19 | Uif (University Industry Foundation), Yonsei University | Anti-ptk7 antibody, and use thereof |
| WO2024151784A1 (en) * | 2023-01-10 | 2024-07-18 | Expression Therapeutics, Llc | Engineered t cells |
| KR20250158048A (ko) | 2023-03-03 | 2025-11-05 | 아스널 바이오사이언시스, 인크. | Psma 및 ca9을 표적으로 하는 시스템 |
| EP4684212A1 (en) * | 2023-03-22 | 2026-01-28 | Agilent Technologies, Inc. | Immunohistochemistry (ihc) ptk7 scoring protocols and methods for aiding cancer treatments |
| CN117085134A (zh) * | 2023-07-19 | 2023-11-21 | 浙江大学 | Ptk7抑制剂在制备预防或治疗肝癌的药物中的用途 |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
| US12534529B1 (en) | 2024-11-19 | 2026-01-27 | Solve Therapeutics, Inc. | PTK7-binding proteins |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
| US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| GB9710807D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
| GB9710809D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
| US6140081A (en) | 1998-10-16 | 2000-10-31 | The Scripps Research Institute | Zinc finger binding domains for GNN |
| US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| US6453242B1 (en) | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
| US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
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| CA2406864A1 (en) | 2000-02-24 | 2001-08-30 | Life Technologies Corporation | Simultaneous stimulation and concentration of cells |
| JP2002060786A (ja) | 2000-08-23 | 2002-02-26 | Kao Corp | 硬質表面用殺菌防汚剤 |
| US20040224385A1 (en) | 2001-08-20 | 2004-11-11 | Barbas Carlos F | Zinc finger binding domains for cnn |
| US7888121B2 (en) | 2003-08-08 | 2011-02-15 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
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| EA017812B1 (ru) * | 2005-12-08 | 2013-03-29 | Медарекс, Инк. | Выделенное моноклональное антитело или его антигенсвязывающий участок, которые связываются с протеинтирозинкиназой 7 ( ptk7) человека, и их применение |
| HUE041436T2 (hu) | 2009-12-10 | 2019-05-28 | Univ Minnesota | Tal-effektor-közvetített DNS-módosítás |
| SA112330278B1 (ar) | 2011-02-18 | 2015-10-09 | ستيم سينتركس، انك. | مواد ضابطة جديدة وطرق للاستخدام |
| US11041021B2 (en) * | 2014-05-23 | 2021-06-22 | University Of Florida Research Foundation, Incorporated | Car based immunotherapy |
| TWI805109B (zh) * | 2014-08-28 | 2023-06-11 | 美商奇諾治療有限公司 | 對cd19具專一性之抗體及嵌合抗原受體 |
| WO2016069282A1 (en) | 2014-10-31 | 2016-05-06 | The Trustees Of The University Of Pennsylvania | Altering gene expression in modified t cells and uses thereof |
| WO2017172981A2 (en) * | 2016-03-29 | 2017-10-05 | University Of Southern California | Chimeric antigen receptors targeting cancer |
| NZ750256A (en) | 2016-08-03 | 2026-02-27 | Dipersio John F | Gene editing of car-t cells for the treatment of t cell malignancies with chimeric antigen receptors |
| MX2020004185A (es) * | 2017-09-27 | 2021-01-08 | Univ Southern California | Nuevas plataformas para coestimulacion, nuevos diseños car y otras mejoras para terapia celular adoptiva. |
| TW202208412A (zh) * | 2020-05-06 | 2022-03-01 | 瑞士商Crispr治療公司 | 對酪胺酸蛋白激酶樣7(ptk7)特異的經掩蔽的嵌合抗原受體和表現其的免疫細胞 |
-
2019
- 2019-11-07 WO PCT/IB2019/059585 patent/WO2020095248A1/en not_active Ceased
- 2019-11-07 SG SG11202104631SA patent/SG11202104631SA/en unknown
- 2019-11-07 US US17/291,194 patent/US20210290678A1/en not_active Abandoned
- 2019-11-07 BR BR112021008083-0A patent/BR112021008083A2/pt not_active Application Discontinuation
- 2019-11-07 US US16/677,207 patent/US12146157B2/en active Active
- 2019-11-07 CA CA3118830A patent/CA3118830A1/en active Pending
- 2019-11-07 JP JP2021523752A patent/JP2022509017A/ja active Pending
- 2019-11-07 KR KR1020217017025A patent/KR20210092236A/ko not_active Withdrawn
- 2019-11-07 EP EP19804869.6A patent/EP3877421A1/en active Pending
- 2019-11-07 MX MX2021005400A patent/MX2021005400A/es unknown
- 2019-11-07 CN CN201980073056.0A patent/CN112955472A/zh active Pending
- 2019-11-07 AU AU2019374523A patent/AU2019374523A1/en not_active Withdrawn
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2021
- 2021-04-21 IL IL282532A patent/IL282532A/en unknown
- 2021-04-23 ZA ZA2021/02745A patent/ZA202102745B/en unknown
- 2021-04-27 CO CONC2021/0005471A patent/CO2021005471A2/es unknown
- 2021-05-06 PH PH12021551047A patent/PH12021551047A1/en unknown
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2024
- 2024-05-09 JP JP2024076832A patent/JP2024097924A/ja active Pending
- 2024-11-14 US US18/947,327 patent/US20250074965A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BR112021008083A2 (pt) | 2021-08-10 |
| JP2024097924A (ja) | 2024-07-19 |
| IL282532A (en) | 2021-06-30 |
| US20200140815A1 (en) | 2020-05-07 |
| PH12021551047A1 (en) | 2021-12-13 |
| ZA202102745B (en) | 2022-10-26 |
| US20250074965A1 (en) | 2025-03-06 |
| WO2020095248A1 (en) | 2020-05-14 |
| SG11202104631SA (en) | 2021-06-29 |
| KR20210092236A (ko) | 2021-07-23 |
| CO2021005471A2 (es) | 2021-04-30 |
| US12146157B2 (en) | 2024-11-19 |
| CN112955472A (zh) | 2021-06-11 |
| EP3877421A1 (en) | 2021-09-15 |
| CA3118830A1 (en) | 2020-05-14 |
| MX2021005400A (es) | 2021-07-06 |
| US20210290678A1 (en) | 2021-09-23 |
| JP2022509017A (ja) | 2022-01-20 |
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| MK12 | Application lapsed section 141(1)/reg 8.3(2) - applicant filed a written notice of withdrawal |