AU2019323714A1 - Tetrahydropyridopyrimidine derivatives as AhR modulators - Google Patents
Tetrahydropyridopyrimidine derivatives as AhR modulators Download PDFInfo
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- AU2019323714A1 AU2019323714A1 AU2019323714A AU2019323714A AU2019323714A1 AU 2019323714 A1 AU2019323714 A1 AU 2019323714A1 AU 2019323714 A AU2019323714 A AU 2019323714A AU 2019323714 A AU2019323714 A AU 2019323714A AU 2019323714 A1 AU2019323714 A1 AU 2019323714A1
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- Prior art keywords
- indol
- ethyl
- compound according
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- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
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- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
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- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SG10201807244X | 2018-08-24 | ||
| SG10201807244X | 2018-08-24 | ||
| PCT/EP2019/072641 WO2020039093A1 (en) | 2018-08-24 | 2019-08-23 | Tetrahydropyridopyrimidine derivatives as ahr modulators |
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| AU2019323714A1 true AU2019323714A1 (en) | 2021-03-25 |
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| EP (1) | EP3841102B1 (https=) |
| JP (1) | JP2021535213A (https=) |
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| CN (1) | CN112739698A (https=) |
| AU (1) | AU2019323714A1 (https=) |
| BR (1) | BR112021003529A2 (https=) |
| CA (1) | CA3110402A1 (https=) |
| IL (1) | IL281023A (https=) |
| MX (1) | MX2021002215A (https=) |
| PH (1) | PH12021550382A1 (https=) |
| SG (1) | SG11202101441SA (https=) |
| WO (1) | WO2020039093A1 (https=) |
| ZA (1) | ZA202100931B (https=) |
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| EP3715471A1 (en) | 2019-03-29 | 2020-09-30 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Ahr signature marker set |
| EP3721894A1 (en) | 2019-04-10 | 2020-10-14 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Interleukin-4-induced gene 1 (il4i1) as a biomarker and uses thereof |
| EP3835432A1 (en) | 2019-12-10 | 2021-06-16 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Interleukin-4-induced gene 1 (il4i1) and respective metabolites as biomarkers for cancer |
| JP2023515128A (ja) | 2020-02-26 | 2023-04-12 | ジャガー セラピューティクス ピーティーイーリミテッド | Ａｈｒシグナル伝達の調節に有用なピリドピリミジン誘導体 |
| BR112022020965A2 (pt) * | 2020-04-17 | 2022-12-06 | Dong A St Co Ltd | Derivados de piridopirimidinona e seu uso como moduladores de receptores de hidrocarboneto arila |
| CN114369097B (zh) * | 2020-10-15 | 2023-07-14 | 山东轩竹医药科技有限公司 | 杂芳环类AhR抑制剂 |
| WO2023033741A1 (en) * | 2021-09-02 | 2023-03-09 | Jaguahr Therapeutics Pte Ltd | Compounds useful in modulation of ahr signalling |
| WO2023033742A1 (en) * | 2021-09-02 | 2023-03-09 | Jaguahr Therapeutics Pte Ltd | Compounds useful in modulation of ahr signalling |
| CN119948035A (zh) | 2022-10-03 | 2025-05-06 | 捷豹治疗有限公司 | 可用于调节AhR信号传导的化合物 |
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| US5980898A (en) | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
| WO2002022605A1 (en) | 2000-09-15 | 2002-03-21 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| CN1894222A (zh) * | 2003-08-05 | 2007-01-10 | 沃泰克斯药物股份有限公司 | 作为电压门控离子通道抑制剂的稠合嘧啶化合物 |
| WO2006044762A2 (en) * | 2004-10-15 | 2006-04-27 | Bayer Pharmaceuticals Corporation | Tetrahydro-5h-pyrimido[4,5-d]azepine derivatives useful for the treatment of diseases associated with the 5-ht2c receptor |
| JP2012504591A (ja) | 2008-10-02 | 2012-02-23 | レスピバート・リミテツド | ｐ３８ＭＡＰキナーゼ阻害剤 |
| PE20100362A1 (es) * | 2008-10-30 | 2010-05-27 | Irm Llc | Derivados de purina que expanden las celulas madre hematopoyeticas |
| EP2467382B1 (en) * | 2009-08-17 | 2014-06-25 | Merck Sharp & Dohme Corp. | Amino tetrahydro-pyridopyrimidine pde10 inhibitors |
| AU2011282776B2 (en) | 2010-07-27 | 2014-06-12 | Boston Medical Center Corporation | Aryl hydrocarbon receptor (AhR) modifiers as novel cancer therapeutics |
| WO2016154110A1 (en) * | 2015-03-20 | 2016-09-29 | Cleave Biosciences, Inc. | Companion diagnostic for p97 inhibitor therapy and methods of use thereof |
| AU2017269870A1 (en) | 2016-05-25 | 2018-12-06 | Bayer Pharma Aktiengesellschaft | 3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamides |
| JP2023515128A (ja) | 2020-02-26 | 2023-04-12 | ジャガー セラピューティクス ピーティーイーリミテッド | Ａｈｒシグナル伝達の調節に有用なピリドピリミジン誘導体 |
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2019
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- 2019-08-23 AU AU2019323714A patent/AU2019323714A1/en not_active Abandoned
- 2019-08-23 EP EP19769387.2A patent/EP3841102B1/en active Active
- 2019-08-23 US US17/270,626 patent/US12221439B2/en active Active
- 2019-08-23 BR BR112021003529-0A patent/BR112021003529A2/pt not_active Application Discontinuation
- 2019-08-23 MX MX2021002215A patent/MX2021002215A/es unknown
- 2019-08-23 SG SG11202101441SA patent/SG11202101441SA/en unknown
- 2019-08-23 KR KR1020217008532A patent/KR20210049135A/ko not_active Ceased
- 2019-08-23 CN CN201980060477.XA patent/CN112739698A/zh active Pending
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- 2021-02-22 IL IL281023A patent/IL281023A/en unknown
- 2021-02-24 PH PH12021550382A patent/PH12021550382A1/en unknown
Also Published As
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|---|---|
| ZA202100931B (en) | 2021-10-27 |
| US20210332041A1 (en) | 2021-10-28 |
| CA3110402A1 (en) | 2020-02-27 |
| KR20210049135A (ko) | 2021-05-04 |
| US12221439B2 (en) | 2025-02-11 |
| SG11202101441SA (en) | 2021-03-30 |
| BR112021003529A2 (pt) | 2021-05-18 |
| JP2021535213A (ja) | 2021-12-16 |
| MX2021002215A (es) | 2021-07-15 |
| IL281023A (en) | 2021-04-29 |
| EP3841102A1 (en) | 2021-06-30 |
| WO2020039093A1 (en) | 2020-02-27 |
| EP3841102B1 (en) | 2022-09-14 |
| CN112739698A (zh) | 2021-04-30 |
| PH12021550382A1 (en) | 2021-12-13 |
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