AU2019306023B2 - Drug delivery devices - Google Patents

Drug delivery devices Download PDF

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Publication number
AU2019306023B2
AU2019306023B2 AU2019306023A AU2019306023A AU2019306023B2 AU 2019306023 B2 AU2019306023 B2 AU 2019306023B2 AU 2019306023 A AU2019306023 A AU 2019306023A AU 2019306023 A AU2019306023 A AU 2019306023A AU 2019306023 B2 AU2019306023 B2 AU 2019306023B2
Authority
AU
Australia
Prior art keywords
cartridge
housing
dose
members
piston rod
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2019306023A
Other languages
English (en)
Other versions
AU2019306023A1 (en
Inventor
Paul Griffin
Ian MCFAUL
David Aubrey Plumptre
Hugh Smith
Robert Veasey
Steven Wimpenny
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of AU2019306023A1 publication Critical patent/AU2019306023A1/en
Application granted granted Critical
Publication of AU2019306023B2 publication Critical patent/AU2019306023B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/002—Packages specially adapted therefor, e.g. packages for syringes or needles or kits for diabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31563—Mechanically operated dose setting member interacting with a displaceable stop member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/31568—Means keeping track of the total dose administered, e.g. since the cartridge was inserted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/3157—Means providing feedback signals when administration is completed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features; Drive mechanisms or modes for piston rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic
    • A61M2005/2477—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic comprising means to reduce play of ampoule within ampoule holder, e.g. springs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or cartridges, e.g. automatic
    • A61M2005/2485—Ampoule holder connected to rest of syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3125—Display means, e.g. to indicate dose setting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/43—General characteristics of the apparatus making noise when used correctly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/582—Means for facilitating use, e.g. by people with impaired vision by tactile feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/60—General characteristics of the apparatus with identification means
    • A61M2205/6045—General characteristics of the apparatus with identification means having complementary physical shapes for indexing or registration purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicinal Preparation (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
AU2019306023A 2018-07-18 2019-07-15 Drug delivery devices Active AU2019306023B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18305979.9 2018-07-18
EP18305979.9A EP3597233A1 (en) 2018-07-18 2018-07-18 Drug delivery devices
PCT/EP2019/068974 WO2020016165A1 (en) 2018-07-18 2019-07-15 Drug delivery devices

Publications (2)

Publication Number Publication Date
AU2019306023A1 AU2019306023A1 (en) 2021-03-11
AU2019306023B2 true AU2019306023B2 (en) 2025-02-13

Family

ID=63103870

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2019306023A Active AU2019306023B2 (en) 2018-07-18 2019-07-15 Drug delivery devices

Country Status (10)

Country Link
US (2) US12138430B2 (enExample)
EP (3) EP3597233A1 (enExample)
JP (1) JP7430170B2 (enExample)
KR (1) KR102697814B1 (enExample)
CN (2) CN112423802B (enExample)
AU (1) AU2019306023B2 (enExample)
BR (1) BR112021000622A2 (enExample)
IL (1) IL280184B2 (enExample)
MX (1) MX2021000682A (enExample)
WO (1) WO2020016165A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3597233A1 (en) * 2018-07-18 2020-01-22 Sanofi Drug delivery devices
WO2021262175A1 (en) * 2020-06-25 2021-12-30 Bard Peripheral Vascular, Inc. Vial geometries for optimal mixing
US12485229B2 (en) 2020-07-15 2025-12-02 Novo Nordisk A/S Reusable torsion spring driven injection device
US20230364348A1 (en) * 2020-09-25 2023-11-16 Becton, Dickinson And Company Biasing Member for Medical Injection Device
EP4070832A1 (en) 2021-04-07 2022-10-12 medmix Switzerland AG Keyed connectors
EP4104881A1 (en) * 2021-06-17 2022-12-21 Sanofi Drug delivery device and method for operating a drug delivery device
USD1038387S1 (en) * 2022-06-15 2024-08-06 Neuroderm, Ltd. Bayonet plunger rod
USD1039138S1 (en) * 2022-06-15 2024-08-13 Neuroderm, Ltd. Snap fit plunger rod
WO2025157561A1 (en) * 2024-01-24 2025-07-31 Shl Medical Ag A sub-assembly for a medicament delivery device
KR102972474B1 (ko) * 2025-10-21 2026-06-02 주식회사 에머티바이오 에녹사파린 약물의 펜타입 카트리지 일체형 자가주사 제형

Citations (4)

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US20050171476A1 (en) * 2002-05-24 2005-08-04 Judson Jared A. Medication injecting apparatus with fluid container piston-engaging drive member having internal hollow for accommodating drive member shifting mechanism
US20130310746A1 (en) * 2010-12-22 2013-11-21 Owen Mumford Limited Autoinjectors
US20170000955A1 (en) * 2014-01-27 2017-01-05 Ucb Biopharma Sprl Auto-injector
US20170312435A1 (en) * 2014-11-12 2017-11-02 Novo Nordisk A/S A Method of Manufacturing One of a Range of Autoinjectors

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US2904043A (en) * 1954-02-10 1959-09-15 Friedman Benjamin Hypodermic syringes
CA2457949A1 (en) 2001-08-27 2003-03-06 Novo-Nordisk A/S A cartridge and a medical delivery system accommodating such a cartridge
GB0304822D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
WO2008009645A1 (en) 2006-07-15 2008-01-24 Novo Nordisk A/S Medical delivery system with asymmetrical coding means
AU2008223867A1 (en) * 2007-03-02 2008-09-12 Novo Nordisk A/S Medication delivery device with pre-set bolus pump
PL2468344T3 (pl) 2008-10-13 2013-12-31 Sanofi Aventis Deutschland Urządzenie podające lek i sposób wytwarzania urządzenia podającego lek
US9457150B2 (en) 2009-06-01 2016-10-04 Sanofi-Aventis Deutschland Gmbh Biasing mechanism for a drug delivery device
TWI530306B (zh) 2009-06-02 2016-04-21 賽諾菲阿凡提斯德意志有限公司 藥物傳送裝置總成及藥物傳送裝置
US10166338B2 (en) 2009-09-21 2019-01-01 Novo Nordisk A/S Drug delivery system and device with cap function
CN103153371B (zh) * 2010-10-13 2015-10-07 赛诺菲-安万特德国有限公司 用于药物递送装置的剂量设定机构
US20120101475A1 (en) * 2010-10-21 2012-04-26 Meridian Medical Technologies, Inc. High Efficiency Auto-Injector
TWI459986B (zh) 2010-11-08 2014-11-11 瑞健集團股份有限公司 容器支撐總成
PL2688613T3 (pl) 2011-03-25 2018-05-30 Sanofi-Aventis Deutschland Gmbh Urządzenie do podawania leków
EP2890435B1 (en) 2012-08-31 2020-03-04 Sanofi-Aventis Deutschland GmbH Drug delivery device
EP2829292B1 (de) 2013-07-22 2017-11-01 TecPharma Licensing AG Antriebs- und Dosiervorrichtung mit einem Begrenzungselement zur Verhinderung der Einstellung einer höheren Dosis als verfügbar
EP3193984A1 (en) 2014-09-18 2017-07-26 Novo Nordisk A/S Drug delivery device with cartridge centring feature
US10265475B2 (en) 2014-10-23 2019-04-23 Antares Pharma, Inc. Cartridge retainer for an injection device
US10518036B2 (en) 2014-12-12 2019-12-31 SHL Medical, AG Dose setting mechanism and medicament delivery device comprising the dose setting mechanism
CN107743406B (zh) 2015-03-23 2020-12-11 赛诺菲-安万特德国有限公司 注射装置
WO2017029032A1 (en) * 2015-08-19 2017-02-23 Carebay Europe Ltd Variable single dose medicament delivery device
US10898646B2 (en) 2016-04-29 2021-01-26 Shl Medical Ag Container holder assembly
US20180056009A1 (en) * 2016-09-01 2018-03-01 Medimop Medical Projects Ltd. Injector with variable dosage
EP3597233A1 (en) * 2018-07-18 2020-01-22 Sanofi Drug delivery devices

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050171476A1 (en) * 2002-05-24 2005-08-04 Judson Jared A. Medication injecting apparatus with fluid container piston-engaging drive member having internal hollow for accommodating drive member shifting mechanism
US20130310746A1 (en) * 2010-12-22 2013-11-21 Owen Mumford Limited Autoinjectors
US20170000955A1 (en) * 2014-01-27 2017-01-05 Ucb Biopharma Sprl Auto-injector
US20170312435A1 (en) * 2014-11-12 2017-11-02 Novo Nordisk A/S A Method of Manufacturing One of a Range of Autoinjectors

Also Published As

Publication number Publication date
EP4755420A3 (en) 2026-08-12
JP2021530302A (ja) 2021-11-11
BR112021000622A2 (pt) 2021-04-20
AU2019306023A1 (en) 2021-03-11
EP3823690B1 (en) 2026-05-27
JP7430170B2 (ja) 2024-02-09
US12138430B2 (en) 2024-11-12
KR20210033020A (ko) 2021-03-25
WO2020016165A1 (en) 2020-01-23
EP4755420A2 (en) 2026-06-10
IL280184B2 (en) 2024-12-01
US20210290850A1 (en) 2021-09-23
CN112423802A (zh) 2021-02-26
EP3597233A1 (en) 2020-01-22
EP3823690C0 (en) 2026-05-27
MX2021000682A (es) 2021-03-25
IL280184A (en) 2021-03-01
IL280184B1 (en) 2024-08-01
CN112423802B (zh) 2023-09-15
EP3823690A1 (en) 2021-05-26
KR102697814B1 (ko) 2024-08-22
CN117599285A (zh) 2024-02-27
US20250032719A1 (en) 2025-01-30

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