AU2019263865B2 - Crystal form of thiophene derivative - Google Patents

Crystal form of thiophene derivative Download PDF

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Publication number
AU2019263865B2
AU2019263865B2 AU2019263865A AU2019263865A AU2019263865B2 AU 2019263865 B2 AU2019263865 B2 AU 2019263865B2 AU 2019263865 A AU2019263865 A AU 2019263865A AU 2019263865 A AU2019263865 A AU 2019263865A AU 2019263865 B2 AU2019263865 B2 AU 2019263865B2
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Prior art keywords
ethoxy
methoxyphenyl
ethyl
pyrrole
crystal form
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AU2019263865A1 (en
Inventor
Yukun CHANG
Liyu WANG
Donglei ZHANG
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Tianjin Hemay Pharmaceutical Co Ltd
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Tianjin Hemay Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
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  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
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AU2019263865A 2018-05-02 2019-04-30 Crystal form of thiophene derivative Active AU2019263865B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201810407741.X 2018-05-02
CN201810407741 2018-05-02
PCT/CN2019/085327 WO2019210864A1 (zh) 2018-05-02 2019-04-30 噻吩衍生物的晶型

Publications (2)

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AU2019263865A1 AU2019263865A1 (en) 2020-12-24
AU2019263865B2 true AU2019263865B2 (en) 2022-01-27

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AU2019263865A Active AU2019263865B2 (en) 2018-05-02 2019-04-30 Crystal form of thiophene derivative
AU2019262282A Active AU2019262282B2 (en) 2018-05-02 2019-04-30 Crystal form of thiophene derivative
AU2019262284A Abandoned AU2019262284A1 (en) 2018-05-02 2019-04-30 Solid form of thiophene derivative
AU2019262286A Active AU2019262286B2 (en) 2018-05-02 2019-04-30 Thiophene derivative crystal form

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AU2019262282A Active AU2019262282B2 (en) 2018-05-02 2019-04-30 Crystal form of thiophene derivative
AU2019262284A Abandoned AU2019262284A1 (en) 2018-05-02 2019-04-30 Solid form of thiophene derivative
AU2019262286A Active AU2019262286B2 (en) 2018-05-02 2019-04-30 Thiophene derivative crystal form

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US (4) US11396518B2 (https=)
EP (5) EP3789389B1 (https=)
JP (5) JP2021523935A (https=)
KR (4) KR102839924B1 (https=)
CN (7) CN116813637A (https=)
AU (4) AU2019263865B2 (https=)
BR (4) BR112020021976A2 (https=)
CA (4) CA3213055A1 (https=)
DK (1) DK3789389T3 (https=)
ES (1) ES3047059T3 (https=)
FI (1) FI3789389T3 (https=)
PL (1) PL3789389T3 (https=)
PT (1) PT3789389T (https=)
WO (4) WO2019210864A1 (https=)

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CN116813637A (zh) 2018-05-02 2023-09-29 天津合美医药科技有限公司 噻吩衍生物的晶型
WO2025103428A1 (zh) * 2023-11-14 2025-05-22 赣州和美药业股份有限公司 中重度斑块型银屑病的治疗

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101885731A (zh) * 2009-05-14 2010-11-17 天津和美生物技术有限公司 噻吩衍生物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6020358A (en) * 1998-10-30 2000-02-01 Celgene Corporation Substituted phenethylsulfones and method of reducing TNFα levels
AU2003243153A1 (en) * 2002-04-23 2003-11-10 Dr. Reddy's Laboratories Limited Novel crystalline polymorph form-vi of olanzapine and a process for preparation thereof
CN101186612B (zh) * 2006-11-15 2012-10-03 天津和美生物技术有限公司 可抑制细胞释放肿瘤坏死因子的吡咯啉衍生物及其制备和应用
WO2012000499A1 (en) 2010-06-30 2012-01-05 Leo Pharma A/S New polymorphic form of a calcimimetic compound
WO2015082583A1 (en) * 2013-12-05 2015-06-11 F. Hoffmann-La Roche Ag Heteroaryl pyridone and aza-pyridone compounds with electrophilic functionality
IL297649A (en) 2014-07-18 2022-12-01 Green Cross Corp Crystalline form of 5-chloro-m ({5)-2-oxo-3-[4-(6,5-dihydro-4-[1,2,4]triazin-1yl)phenyl}-1,3- Oxazolidine-5-yl} methyl) thiophene-2-an innovative carboxamide and pharmaceutical preparations containing it
EP3144393A1 (en) * 2015-09-18 2017-03-22 LEK Pharmaceuticals d.d. A synthetic pathway towards apremilast
CN107417626B (zh) * 2016-05-23 2020-01-24 江苏奥赛康药业有限公司 一种2-氨基嘧啶类化合物的多晶型形式
CN107474057B (zh) * 2016-06-07 2021-03-12 天津药物研究院有限公司 (5-(2-腈基苄基)-4,5,6,7-四氢噻吩并[3,2-c]吡啶-2-基)乙酸酯盐酸盐的晶型及其制备方法和用途
US10570147B2 (en) 2017-06-13 2020-02-25 Biotheryx, Inc. Bicyclic compounds and methods of use
ES2979170T3 (es) * 2017-06-30 2024-09-24 Trophy Aparato de formación de imágenes dentales extraorales con detección de accesorios para el posicionamiento del paciente
CN116813637A (zh) * 2018-05-02 2023-09-29 天津合美医药科技有限公司 噻吩衍生物的晶型

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101885731A (zh) * 2009-05-14 2010-11-17 天津和美生物技术有限公司 噻吩衍生物

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EP3789389A4 (en) 2022-01-26
EP4335515A2 (en) 2024-03-13
KR20210022557A (ko) 2021-03-03
BR112020022190A2 (pt) 2021-02-02
EP3789389A1 (en) 2021-03-10
CN110437250B (zh) 2023-06-23
WO2019210864A1 (zh) 2019-11-07
CN110437250A (zh) 2019-11-12
EP3789387A4 (en) 2021-06-30
AU2019262284A1 (en) 2020-12-24
AU2019262282B2 (en) 2022-04-28
WO2019210865A1 (zh) 2019-11-07
KR102701245B1 (ko) 2024-08-30
EP3789388B1 (en) 2024-01-24
JP7477459B2 (ja) 2024-05-01
US20210139498A1 (en) 2021-05-13
DK3789389T3 (da) 2025-11-10
CN116813637A (zh) 2023-09-29
BR112020022186A2 (pt) 2021-02-02
EP3789387B1 (en) 2024-02-28
EP3789387A1 (en) 2021-03-10
AU2019262286B2 (en) 2022-08-11
EP3789388A4 (en) 2021-06-09
US20210380600A1 (en) 2021-12-09
KR102839924B1 (ko) 2025-07-29
US20210230181A1 (en) 2021-07-29
AU2019263865A1 (en) 2020-12-24
CN110437251A (zh) 2019-11-12
CA3099071A1 (en) 2019-11-07
KR20210025001A (ko) 2021-03-08
CN110437249A (zh) 2019-11-12
CN110437251B (zh) 2023-07-21
AU2019262282A1 (en) 2020-11-12
US12227514B2 (en) 2025-02-18
US20210238191A1 (en) 2021-08-05
CA3213055A1 (en) 2019-11-07
BR112020021976A2 (pt) 2021-01-26
CA3098927C (en) 2023-10-03
US11396518B2 (en) 2022-07-26
AU2019262286A1 (en) 2020-11-12
KR102686835B1 (ko) 2024-07-22
CN116854705A (zh) 2023-10-10
JP2021523890A (ja) 2021-09-09
JP2021523935A (ja) 2021-09-09
EP4335515A3 (en) 2024-07-03
CN116947878A (zh) 2023-10-27
PL3789389T3 (pl) 2026-03-16
EP3800190A4 (en) 2022-01-26
US11274104B2 (en) 2022-03-15
BR112020021945A2 (pt) 2021-01-26
CA3098931C (en) 2023-10-24
CN110437249B (zh) 2023-07-21
WO2019210869A1 (zh) 2019-11-07
FI3789389T3 (fi) 2025-11-19
EP3800190A1 (en) 2021-04-07
JP2021523891A (ja) 2021-09-09
CA3098931A1 (en) 2019-11-07
EP3789388A1 (en) 2021-03-10
ES3047059T3 (en) 2025-12-03
US12180222B2 (en) 2024-12-31
CA3098927A1 (en) 2019-11-07
KR20210025000A (ko) 2021-03-08
WO2019210867A1 (zh) 2019-11-07
JP7481263B2 (ja) 2024-05-10
CA3099072A1 (en) 2019-11-07
JP2024026251A (ja) 2024-02-28
JP7542523B2 (ja) 2024-08-30
CN116836178A (zh) 2023-10-03
JP2021522348A (ja) 2021-08-30
KR20210022556A (ko) 2021-03-03
PT3789389T (pt) 2025-12-17
EP3789389B1 (en) 2025-10-08

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