AU2019236288B2 - Methods and compositions for inducible expression of neurotrophic factors - Google Patents

Methods and compositions for inducible expression of neurotrophic factors Download PDF

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AU2019236288B2
AU2019236288B2 AU2019236288A AU2019236288A AU2019236288B2 AU 2019236288 B2 AU2019236288 B2 AU 2019236288B2 AU 2019236288 A AU2019236288 A AU 2019236288A AU 2019236288 A AU2019236288 A AU 2019236288A AU 2019236288 B2 AU2019236288 B2 AU 2019236288B2
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gdnf
cells
expression cassette
promoter
inpcs
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AU2019236288A1 (en
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Aslam AKHTAR
Joshua BREUNIG
Clive Svendsen
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Cedars Sinai Medical Center
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    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
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    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/475—Growth factors; Growth regulators
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AU2019236288A 2018-03-16 2019-03-15 Methods and compositions for inducible expression of neurotrophic factors Active AU2019236288B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862644332P 2018-03-16 2018-03-16
US62/644,332 2018-03-16
US201862773752P 2018-11-30 2018-11-30
US62/773,752 2018-11-30
PCT/US2019/022595 WO2019178550A1 (en) 2018-03-16 2019-03-15 Methods and compositions for inducible expression of neurotrophic factors

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AU2019236288A1 AU2019236288A1 (en) 2020-09-17
AU2019236288B2 true AU2019236288B2 (en) 2025-06-05

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US (1) US12258571B2 (https=)
EP (1) EP3765058A4 (https=)
JP (2) JP7535944B2 (https=)
KR (1) KR102843346B1 (https=)
CN (1) CN111867617A (https=)
AU (1) AU2019236288B2 (https=)
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JP2024073654A (ja) 2024-05-29
KR102843346B1 (ko) 2025-08-06
JP7535944B2 (ja) 2024-08-19
US20210024955A1 (en) 2021-01-28
EP3765058A4 (en) 2021-12-22
US12258571B2 (en) 2025-03-25
KR20200132957A (ko) 2020-11-25
CA3092284A1 (en) 2019-09-19
JP2021518365A (ja) 2021-08-02
CN111867617A (zh) 2020-10-30
EP3765058A1 (en) 2021-01-20
AU2019236288A1 (en) 2020-09-17
WO2019178550A1 (en) 2019-09-19

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