CN111867617A - 用于神经营养因子的诱导型表达的组合物和方法 - Google Patents
用于神经营养因子的诱导型表达的组合物和方法 Download PDFInfo
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- CN111867617A CN111867617A CN201980019683.6A CN201980019683A CN111867617A CN 111867617 A CN111867617 A CN 111867617A CN 201980019683 A CN201980019683 A CN 201980019683A CN 111867617 A CN111867617 A CN 111867617A
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- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
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- C07K14/475—Growth factors; Growth regulators
- C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
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- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
- C12N2830/003—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor tet inducible
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/20—Vector systems having a special element relevant for transcription transcription of more than one cistron
- C12N2830/205—Vector systems having a special element relevant for transcription transcription of more than one cistron bidirectional
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862644332P | 2018-03-16 | 2018-03-16 | |
| US62/644,332 | 2018-03-16 | ||
| US201862773752P | 2018-11-30 | 2018-11-30 | |
| US62/773,752 | 2018-11-30 | ||
| PCT/US2019/022595 WO2019178550A1 (en) | 2018-03-16 | 2019-03-15 | Methods and compositions for inducible expression of neurotrophic factors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111867617A true CN111867617A (zh) | 2020-10-30 |
Family
ID=67907321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980019683.6A Pending CN111867617A (zh) | 2018-03-16 | 2019-03-15 | 用于神经营养因子的诱导型表达的组合物和方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US12258571B2 (https=) |
| EP (1) | EP3765058A4 (https=) |
| JP (2) | JP7535944B2 (https=) |
| KR (1) | KR102843346B1 (https=) |
| CN (1) | CN111867617A (https=) |
| AU (1) | AU2019236288B2 (https=) |
| WO (1) | WO2019178550A1 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11466290B2 (en) | 2016-01-26 | 2022-10-11 | Cedars-Sinai Medical Center | Systems and methods for in vivo dual recombinase-mediated cassette exchange (dRMCE) and disease models thereof |
| WO2025002240A1 (en) * | 2023-06-29 | 2025-01-02 | The University Of Hong Kong | Method for controllable transcription in liver or liver cancer |
| US12258571B2 (en) | 2018-03-16 | 2025-03-25 | Cedars-Sinai Medical Center | Methods and compositions for inducible expression of neurotrophic factors |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190018000A1 (en) | 2016-01-12 | 2019-01-17 | Cedars-Sinai Medical Center | A method of non destructive monitoring of biological processes in microfluidic tissue culture systems |
| US11913022B2 (en) | 2017-01-25 | 2024-02-27 | Cedars-Sinai Medical Center | In vitro induction of mammary-like differentiation from human pluripotent stem cells |
| US11767513B2 (en) | 2017-03-14 | 2023-09-26 | Cedars-Sinai Medical Center | Neuromuscular junction |
| WO2018176001A2 (en) | 2017-03-24 | 2018-09-27 | Cedars-Sinai Medical Center | Methods and compositions for production of fallopian tube epithelium |
| EP4700387A2 (en) | 2018-03-23 | 2026-02-25 | Cedars-Sinai Medical Center | Methods of use of islet cells |
| WO2019195800A1 (en) | 2018-04-06 | 2019-10-10 | Cedars-Sinai Medical Center | Novel differentiation technique to generate dopaminergic neurons from induced pluripotent stem cells |
| WO2019195798A1 (en) | 2018-04-06 | 2019-10-10 | Cedars-Sinai Medical Center | Human pluripotent stem cell derived neurodegenerative disease models on a microfluidic chip |
| EP3787613B1 (en) | 2018-04-30 | 2026-03-11 | Cedars-Sinai Medical Center | Pkc activation for use in treating early onset sporadic parkinson's disease |
| WO2020084168A1 (en) * | 2018-10-26 | 2020-04-30 | Icm (Institut Du Cerveau Et De La Moelle Épinière) | Tetracycline compound for treating drug-induced dyskinesia |
| CA3158428A1 (en) * | 2019-10-22 | 2021-04-29 | Cedars-Sinai Medical Center | Cortical neural progenitor cells from ipscs |
| US20230047254A1 (en) * | 2019-12-29 | 2023-02-16 | Gloriana Therapeutics | Mammalian Cells Secreting GDNF and Their Therapeutic Use |
| KR20220061403A (ko) * | 2020-11-06 | 2022-05-13 | (주) 에스바이오메딕스 | 다능성 줄기세포 유래 신경전구세포를 포함하는 퇴행성 뇌질환 치료용 약학적 조성물 |
| GB202312699D0 (en) * | 2023-08-18 | 2023-10-04 | Cambridge Entpr Ltd | Controllable expression in mammalian cells |
| WO2025091023A1 (en) * | 2023-10-27 | 2025-05-01 | Northwestern University | Engineered cell transfected by all-in-one vector for therapeutic agents production and delivery and applications thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030228295A1 (en) * | 2002-04-25 | 2003-12-11 | Svendsen Clive N. | Use of human neural stem cells secreting GDNF for treatment of parkinson's and other neurodegenerative diseases |
| US20120107284A1 (en) * | 2006-06-30 | 2012-05-03 | Elena Kozlova | Stem cells for transplantation and methods for production thereof |
| CN102816793A (zh) * | 2012-08-22 | 2012-12-12 | 陕西师范大学 | 单载体双向启动的Tet-on诱导表达系统及其构建方法和应用 |
| WO2017131926A1 (en) * | 2016-01-26 | 2017-08-03 | Cedars-Sinai Medical Center | SYSTEMS AND METHODS FOR IN VIVO DUAL RECOMBINASE-MEDIATED CASSETTE EXCHANGE (dRMCE) AND DISEASE MODELS THEREOF |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7575924B2 (en) | 2000-11-13 | 2009-08-18 | Research Development Foundation | Methods and compositions relating to improved lentiviral vectors and their applications |
| WO2003020743A1 (en) | 2001-09-05 | 2003-03-13 | Regeneron Pharmaceuticals, Inc. | Methods of expressing transgenes |
| GB2404382B (en) | 2003-07-28 | 2008-01-30 | Oxitec Ltd | Pest control |
| WO2008079608A1 (en) | 2006-12-21 | 2008-07-03 | Genentech, Inc. | Compositions and methods for the expression of nucleic acids |
| US8592211B2 (en) * | 2009-03-20 | 2013-11-26 | The Rockefeller University | Enhanced PiggyBac transposon and methods for transposon mutagenesis |
| US20120107938A1 (en) | 2009-06-29 | 2012-05-03 | University Of Basel | Methods and kits for high efficiency engineering of conditional mouse alleles |
| WO2013155222A2 (en) | 2012-04-10 | 2013-10-17 | The Regents Of The University Of California | Brain-specific enhancers for cell-based therapy |
| WO2014127289A1 (en) * | 2013-02-15 | 2014-08-21 | International Stem Cell Corporation | Use of neural cells derived from human pluripotent stem cells for the treatment of neurodegenerative diseases |
| JP6473077B2 (ja) * | 2013-03-21 | 2019-02-20 | 国立大学法人京都大学 | 神経分化誘導用の多能性幹細胞 |
| WO2014204724A1 (en) | 2013-06-17 | 2014-12-24 | The Broad Institute Inc. | Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation |
| ES2939807T3 (es) | 2014-03-21 | 2023-04-27 | Fujifilm Cellular Dynamics Inc | Producción de neuronas dopaminérgicas del mesencéfalo y métodos para su utilización |
| AU2015234242B2 (en) * | 2014-03-21 | 2020-09-24 | Children's Medical Research Institute | Stable gene transfer to proliferating cells |
| US20170274048A1 (en) | 2014-03-28 | 2017-09-28 | Buck Institute For Research On Aging | Methods and compositions for modulating the imune system |
| EP3584312A1 (en) | 2014-06-27 | 2019-12-25 | Angiocrine Bioscience, Inc. | Neural cells expressing adenovirus e4orf1, and methods of making and using the same |
| KR20250141836A (ko) | 2015-11-04 | 2025-09-29 | 페이트 세러퓨틱스, 인코포레이티드 | 만능 세포의 유전자 조작 |
| US10221395B2 (en) | 2016-06-16 | 2019-03-05 | Cedars-Sinai Medical Center | Efficient method for reprogramming blood to induced pluripotent stem cells |
| US12258571B2 (en) | 2018-03-16 | 2025-03-25 | Cedars-Sinai Medical Center | Methods and compositions for inducible expression of neurotrophic factors |
| CA3143981A1 (en) | 2019-06-17 | 2020-12-24 | Cedars-Sinai Medical Center | Systems and methods for in vivo dual recombinase-mediated cassette exchange (drmce) and disease models thereof |
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2019
- 2019-03-15 US US16/979,640 patent/US12258571B2/en active Active
- 2019-03-15 AU AU2019236288A patent/AU2019236288B2/en active Active
- 2019-03-15 WO PCT/US2019/022595 patent/WO2019178550A1/en not_active Ceased
- 2019-03-15 KR KR1020207029729A patent/KR102843346B1/ko active Active
- 2019-03-15 EP EP19768063.0A patent/EP3765058A4/en active Pending
- 2019-03-15 JP JP2020549702A patent/JP7535944B2/ja active Active
- 2019-03-15 CN CN201980019683.6A patent/CN111867617A/zh active Pending
-
2024
- 2024-03-25 JP JP2024047652A patent/JP2024073654A/ja active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030228295A1 (en) * | 2002-04-25 | 2003-12-11 | Svendsen Clive N. | Use of human neural stem cells secreting GDNF for treatment of parkinson's and other neurodegenerative diseases |
| US20120107284A1 (en) * | 2006-06-30 | 2012-05-03 | Elena Kozlova | Stem cells for transplantation and methods for production thereof |
| CN102816793A (zh) * | 2012-08-22 | 2012-12-12 | 陕西师范大学 | 单载体双向启动的Tet-on诱导表达系统及其构建方法和应用 |
| WO2017131926A1 (en) * | 2016-01-26 | 2017-08-03 | Cedars-Sinai Medical Center | SYSTEMS AND METHODS FOR IN VIVO DUAL RECOMBINASE-MEDIATED CASSETTE EXCHANGE (dRMCE) AND DISEASE MODELS THEREOF |
Non-Patent Citations (4)
| Title |
|---|
| CHENSHA-SHA 等: "Intrastriatal GDNF gene transfer by inducible lentivirus vectors protects dopaminergic neurons in a rat model of parkinsonism", 《EXPERIMENTAL NEUROLOGY》, vol. 261, pages 88 * |
| HAKAN ALDSKOGIUS 等: "Regulation of Boundary Cap Neural Crest Stem Cell Differentiation After Transplantation", 《STEMCELLS》, vol. 27, no. 7, pages 1592 - 1603 * |
| WANG SHUYAN 等: "Inducible regulation of GDNF expression in human neural stem cells", 《SCI CHINA LIFE SCI》, vol. 56, no. 1, pages 32 - 39, XP035163654, DOI: 10.1007/s11427-012-4424-6 * |
| YANG WEI-HUA 等: "Regulated Expression of Lentivirus-Mediated GDNF in Human Bone Marrow-Derived Mesenchymal Stem Cells and Its Neuroprotection on Dopaminergic Cells In Vitro", 《PLOS ONE》, vol. 8, no. 5, pages 1 - 12 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11466290B2 (en) | 2016-01-26 | 2022-10-11 | Cedars-Sinai Medical Center | Systems and methods for in vivo dual recombinase-mediated cassette exchange (dRMCE) and disease models thereof |
| US12258571B2 (en) | 2018-03-16 | 2025-03-25 | Cedars-Sinai Medical Center | Methods and compositions for inducible expression of neurotrophic factors |
| WO2025002240A1 (en) * | 2023-06-29 | 2025-01-02 | The University Of Hong Kong | Method for controllable transcription in liver or liver cancer |
Also Published As
| Publication number | Publication date |
|---|---|
| US20210024955A1 (en) | 2021-01-28 |
| WO2019178550A1 (en) | 2019-09-19 |
| JP2024073654A (ja) | 2024-05-29 |
| KR20200132957A (ko) | 2020-11-25 |
| AU2019236288B2 (en) | 2025-06-05 |
| JP2021518365A (ja) | 2021-08-02 |
| US12258571B2 (en) | 2025-03-25 |
| KR102843346B1 (ko) | 2025-08-06 |
| JP7535944B2 (ja) | 2024-08-19 |
| CA3092284A1 (en) | 2019-09-19 |
| AU2019236288A1 (en) | 2020-09-17 |
| EP3765058A1 (en) | 2021-01-20 |
| EP3765058A4 (en) | 2021-12-22 |
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