AU2019229258B2 - Chromene derivatives as inhibitors of TCR-Nck interaction - Google Patents

Chromene derivatives as inhibitors of TCR-Nck interaction Download PDF

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AU2019229258B2
AU2019229258B2 AU2019229258A AU2019229258A AU2019229258B2 AU 2019229258 B2 AU2019229258 B2 AU 2019229258B2 AU 2019229258 A AU2019229258 A AU 2019229258A AU 2019229258 A AU2019229258 A AU 2019229258A AU 2019229258 B2 AU2019229258 B2 AU 2019229258B2
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compound
pharmaceutically acceptable
acceptable salt
compounds
nitrogen
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AU2019229258A1 (en
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Julio Castro
Andrés GAGETE MATEOS
Peter J. Machin
Christopher Loren Vandeusen
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Artax Biopharma Inc
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Artax Biopharma Inc
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
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    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
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AU2019229258A 2018-02-27 2019-02-27 Chromene derivatives as inhibitors of TCR-Nck interaction Active AU2019229258B2 (en)

Priority Applications (1)

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AU2023282201A AU2023282201B2 (en) 2018-02-27 2023-12-12 Chromene derivatives as inhibitors of TCR-Nck interaction

Applications Claiming Priority (3)

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US201862635834P 2018-02-27 2018-02-27
US62/635,834 2018-02-27
PCT/US2019/019856 WO2019169001A1 (en) 2018-02-27 2019-02-27 Chromene derivatives as inhibitors of tcr-nck interaction

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AU2019229258A1 AU2019229258A1 (en) 2020-09-17
AU2019229258B2 true AU2019229258B2 (en) 2023-09-14

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US (5) US10696663B2 (OSRAM)
EP (1) EP3759086A1 (OSRAM)
JP (3) JP7317032B2 (OSRAM)
KR (2) KR20260028873A (OSRAM)
CN (2) CN117304157A (OSRAM)
AU (2) AU2019229258B2 (OSRAM)
BR (1) BR112020017386A2 (OSRAM)
CA (1) CA3091202A1 (OSRAM)
CO (1) CO2020010537A2 (OSRAM)
EA (1) EA202091742A1 (OSRAM)
IL (2) IL301120B2 (OSRAM)
MX (2) MX2020008814A (OSRAM)
PH (1) PH12020500638A1 (OSRAM)
SG (1) SG11202008067QA (OSRAM)
WO (1) WO2019169001A1 (OSRAM)
ZA (1) ZA202310843B (OSRAM)

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Publication number Priority date Publication date Assignee Title
EP3759086A1 (en) 2018-02-27 2021-01-06 Artax Biopharma Inc. Chromene derivatives as inhibitors of tcr-nck interaction
WO2025137442A1 (en) * 2023-12-22 2025-06-26 Artax Biopharma Inc. SOLID AND SALT FORMS OF TCR-NcK MODULATORS AND USES THEREOF
WO2025255093A1 (en) * 2024-06-03 2025-12-11 Artax Biopharma Inc. Combination of a car-t therapy and a chromene derivative tcr inhibitor
WO2025255091A1 (en) * 2024-06-03 2025-12-11 Artax Biopharma Inc. Combination of a chromene derivative tcr inhibitor and a jak inhibitor
WO2025255109A1 (en) * 2024-06-03 2025-12-11 Artax Biopharma Inc. Combination of a chromene derivative tcr inhibitor and a pde4 inhibitor

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