AU2019223076A1 - BCMA-binding antibodies and uses thereof - Google Patents

BCMA-binding antibodies and uses thereof Download PDF

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Publication number
AU2019223076A1
AU2019223076A1 AU2019223076A AU2019223076A AU2019223076A1 AU 2019223076 A1 AU2019223076 A1 AU 2019223076A1 AU 2019223076 A AU2019223076 A AU 2019223076A AU 2019223076 A AU2019223076 A AU 2019223076A AU 2019223076 A1 AU2019223076 A1 AU 2019223076A1
Authority
AU
Australia
Prior art keywords
seq
bcma
antibody
cell
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2019223076A
Other languages
English (en)
Inventor
Mahan ABBASIAN
Henry Chan
Kandasamy Hariharan
Jeonghoon Sun
Andrew Wurmser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celgene Corp
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of AU2019223076A1 publication Critical patent/AU2019223076A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2019223076A 2018-02-21 2019-02-20 BCMA-binding antibodies and uses thereof Abandoned AU2019223076A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862633152P 2018-02-21 2018-02-21
US62/633,152 2018-02-21
PCT/US2019/018698 WO2019164891A1 (en) 2018-02-21 2019-02-20 Bcma-binding antibodies and uses thereof

Publications (1)

Publication Number Publication Date
AU2019223076A1 true AU2019223076A1 (en) 2020-10-08

Family

ID=65686040

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2019223076A Abandoned AU2019223076A1 (en) 2018-02-21 2019-02-20 BCMA-binding antibodies and uses thereof

Country Status (15)

Country Link
US (2) US11401336B2 (enExample)
EP (1) EP3755718A1 (enExample)
JP (1) JP2021514193A (enExample)
KR (1) KR20200123155A (enExample)
CN (1) CN112272675A (enExample)
AR (1) AR115257A1 (enExample)
AU (1) AU2019223076A1 (enExample)
BR (1) BR112020017053A2 (enExample)
CA (1) CA3092037A1 (enExample)
EA (1) EA202091974A1 (enExample)
IL (1) IL276548A (enExample)
MX (1) MX2020008718A (enExample)
SG (1) SG11202007495SA (enExample)
TW (1) TW202000701A (enExample)
WO (1) WO2019164891A1 (enExample)

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AU2021263408A1 (en) * 2020-04-30 2022-10-27 Bristol-Myers Squibb Company Methods of treating cytokine-related adverse events
AU2021345124A1 (en) 2020-09-16 2023-03-30 Amgen Inc. Methods for administering therapeutic doses of bispecific T-cell engaging molecules for the treatment of cancer
CN117242060B (zh) 2021-01-13 2026-07-17 蒙特罗莎治疗股份有限公司 异吲哚啉酮化合物
CN118159563A (zh) * 2021-10-27 2024-06-07 詹森生物科技公司 用于人和猴组织中的增强型bcma免疫组织化学检测的方法
US12692314B2 (en) * 2022-05-06 2026-07-28 IGI Therapeutics SA CD3/BCMA/CD38 trispecific antibodies
PY2342675A (es) * 2022-06-09 2023-12-11 Biocad Joint Stock Co Anticuerpo monoclonal o fragmento de unión al antígeno del mismo que se une específicamente a bcma, y uso del mismo
WO2025184567A1 (en) * 2024-03-01 2025-09-04 Regeneron Pharmaceuticals, Inc. Methods and compositions for re-dosing aav using anti-cd40 antagonistic antibody to suppress host anti-aav antibody response
WO2026072671A1 (en) 2024-09-24 2026-04-02 City Of Hope Methods comprising oncolytic viruses expressing bcmat and bcma-targeted therapies
WO2026072709A1 (en) 2024-09-25 2026-04-02 Orna Therapeutics, Inc. Chimeric antigen receptors targeting bcma

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Also Published As

Publication number Publication date
WO2019164891A1 (en) 2019-08-29
EA202091974A1 (ru) 2020-12-08
TW202000701A (zh) 2020-01-01
IL276548A (en) 2020-09-30
MX2020008718A (es) 2020-12-07
US20220324991A1 (en) 2022-10-13
KR20200123155A (ko) 2020-10-28
WO2019164891A9 (en) 2020-09-17
CN112272675A (zh) 2021-01-26
AR115257A1 (es) 2020-12-16
EP3755718A1 (en) 2020-12-30
BR112020017053A2 (pt) 2020-12-15
CA3092037A1 (en) 2019-08-29
JP2021514193A (ja) 2021-06-10
US11401336B2 (en) 2022-08-02
SG11202007495SA (en) 2020-09-29
US20200399386A1 (en) 2020-12-24

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Legal Events

Date Code Title Description
MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application