AU2018365900B2 - Methods of making deuterium-enriched N-acetylcysteine amide (d-NACA) and (2R,2R')-3,3' -disulfanediyl bis(2-acetamidopropanamide) (diNACA) and using d-NACA and diNACA to treat diseases involving oxidative stress - Google Patents

Methods of making deuterium-enriched N-acetylcysteine amide (d-NACA) and (2R,2R')-3,3' -disulfanediyl bis(2-acetamidopropanamide) (diNACA) and using d-NACA and diNACA to treat diseases involving oxidative stress Download PDF

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AU2018365900B2
AU2018365900B2 AU2018365900A AU2018365900A AU2018365900B2 AU 2018365900 B2 AU2018365900 B2 AU 2018365900B2 AU 2018365900 A AU2018365900 A AU 2018365900A AU 2018365900 A AU2018365900 A AU 2018365900A AU 2018365900 B2 AU2018365900 B2 AU 2018365900B2
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mol
dinaca
naca
acetamidopropanamide
disulfanediyl bis
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AU2018365900A1 (en
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G. Michael Wall
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Nacuity Pharmaceuticals Inc
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Priority to AU2022275499A priority patent/AU2022275499B9/en
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AU2018365900A 2017-11-09 2018-11-06 Methods of making deuterium-enriched N-acetylcysteine amide (d-NACA) and (2R,2R')-3,3' -disulfanediyl bis(2-acetamidopropanamide) (diNACA) and using d-NACA and diNACA to treat diseases involving oxidative stress Active AU2018365900B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2020227015A AU2020227015B2 (en) 2017-11-09 2020-09-01 Methods of making deuterium-enriched n-acetylcysteine amide (d-naca) and (2r,2r’)-3,3’-disulfanediyl bis(2-acetamidopropanamide) (dinaca) and using d-naca and dinaca to treat diseases involving oxidative stress
AU2022275499A AU2022275499B9 (en) 2017-11-09 2022-11-25 Methods of making deuterium-enriched n-acetylcysteine amide (d-naca) and (2r,2r’)-3,3’-disulfanediyl bis(2-acetamidopropanamide) (dinaca) and using d-naca and dinaca to treat diseases involving oxidative stress
AU2025200018A AU2025200018A1 (en) 2017-11-09 2025-01-02 Methods of making deuterium-enriched n-acetylcysteine amide (d-naca) and (2r,2r’)-3,3’-disulfanediyl bis(2-acetamidopropanamide) (dinaca) and using d-naca and dinaca to treat diseases involving oxidative stress

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US201762583984P 2017-11-09 2017-11-09
US62/583,984 2017-11-09
US201762587246P 2017-11-16 2017-11-16
US62/587,246 2017-11-16
US16/180,984 2018-11-05
US16/180,984 US20190135741A1 (en) 2017-11-09 2018-11-05 Methods of Making Deuterium-Enriched N-acetylcysteine Amide (D-NACA) and (2R, 2R')-3,3'-Disulfanediyl BIS(2-Acetamidopropanamide) (DINACA) and Using D-NACA and DINACA to Treat Diseases Involving Oxidative Stress
PCT/US2018/059446 WO2019094383A1 (en) 2017-11-09 2018-11-06 Methods of making deuterium-enriched n-acetylcysteine amide (d-naca) and (2r,2r')-3,3' -disulfanediyl bis(2-acetamidopropanamide) (dinaca) and using d-naca and dinaca to treat diseases involving oxidative stress

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AU2020227015A Division AU2020227015B2 (en) 2017-11-09 2020-09-01 Methods of making deuterium-enriched n-acetylcysteine amide (d-naca) and (2r,2r’)-3,3’-disulfanediyl bis(2-acetamidopropanamide) (dinaca) and using d-naca and dinaca to treat diseases involving oxidative stress

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AU2018365900A1 AU2018365900A1 (en) 2019-06-20
AU2018365900B2 true AU2018365900B2 (en) 2020-06-18

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AU2018365900A Active AU2018365900B2 (en) 2017-11-09 2018-11-06 Methods of making deuterium-enriched N-acetylcysteine amide (d-NACA) and (2R,2R')-3,3' -disulfanediyl bis(2-acetamidopropanamide) (diNACA) and using d-NACA and diNACA to treat diseases involving oxidative stress
AU2020227015A Active AU2020227015B2 (en) 2017-11-09 2020-09-01 Methods of making deuterium-enriched n-acetylcysteine amide (d-naca) and (2r,2r’)-3,3’-disulfanediyl bis(2-acetamidopropanamide) (dinaca) and using d-naca and dinaca to treat diseases involving oxidative stress
AU2022275499A Active AU2022275499B9 (en) 2017-11-09 2022-11-25 Methods of making deuterium-enriched n-acetylcysteine amide (d-naca) and (2r,2r’)-3,3’-disulfanediyl bis(2-acetamidopropanamide) (dinaca) and using d-naca and dinaca to treat diseases involving oxidative stress
AU2025200018A Pending AU2025200018A1 (en) 2017-11-09 2025-01-02 Methods of making deuterium-enriched n-acetylcysteine amide (d-naca) and (2r,2r’)-3,3’-disulfanediyl bis(2-acetamidopropanamide) (dinaca) and using d-naca and dinaca to treat diseases involving oxidative stress

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AU2020227015A Active AU2020227015B2 (en) 2017-11-09 2020-09-01 Methods of making deuterium-enriched n-acetylcysteine amide (d-naca) and (2r,2r’)-3,3’-disulfanediyl bis(2-acetamidopropanamide) (dinaca) and using d-naca and dinaca to treat diseases involving oxidative stress
AU2022275499A Active AU2022275499B9 (en) 2017-11-09 2022-11-25 Methods of making deuterium-enriched n-acetylcysteine amide (d-naca) and (2r,2r’)-3,3’-disulfanediyl bis(2-acetamidopropanamide) (dinaca) and using d-naca and dinaca to treat diseases involving oxidative stress
AU2025200018A Pending AU2025200018A1 (en) 2017-11-09 2025-01-02 Methods of making deuterium-enriched n-acetylcysteine amide (d-naca) and (2r,2r’)-3,3’-disulfanediyl bis(2-acetamidopropanamide) (dinaca) and using d-naca and dinaca to treat diseases involving oxidative stress

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US (2) US20190135741A1 (https=)
EP (1) EP3534890A4 (https=)
JP (1) JP2021502323A (https=)
KR (2) KR20220016304A (https=)
CN (1) CN111201017A (https=)
AU (4) AU2018365900B2 (https=)
CA (2) CA3131442A1 (https=)
RU (1) RU2019126848A (https=)
WO (1) WO2019094383A1 (https=)

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WO2020146660A1 (en) 2019-01-11 2020-07-16 Nacuity Pharmaceuticals, Inc. N-acetylcysteine amide (naca) and (2r,2r')-3-3'-disulfanediyl bis (2-acetamidopropanamide) (dinaca) for prevention and treatment of radiation pneumonitis and treatment of pulmonary function in cystic fibrosis
EP3908271A4 (en) 2019-01-11 2022-10-26 NaCuity Pharmaceuticals, Inc. N-ACETYLCYSTEINE AMIDE (NACA) AND (2R,2R')-3,3'-DISULFANDIYL BIS-(2-ACETAMIDOPROPANAMIDE) (DINACA) FOR THE PREVENTION AND TREATMENT OF RADIATION DERMATITIS AND SKIN LIGHTENING AND IMPROVEMENT
EP3908341A4 (en) 2019-01-11 2022-03-02 NaCuity Pharmaceuticals, Inc. TREATMENT OF AGE-RELATED MACULAR DEGENERATION, GLAUCOMA AND DIABETIC RETINOPATHY WITH N-ACETYLCYSTEINE AMIDE (NACA) OR (2R,2R')-3,3'-BIS(2-ACETAMIDOPROPANAMIDE) DISULFANEDIYL (DINACA)
EP4054553A4 (en) * 2019-11-08 2023-11-29 Retina Foundation of the Southwest JOINTS AND IMPLANTS FOR THE TREATMENT OF EYE DISEASES
WO2021146556A1 (en) * 2020-01-16 2021-07-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Real-time monitoring of in vivo free radical scavengers through hyperpolarized n-acetyl cysteine isotopes
AU2021209953B2 (en) * 2020-01-24 2024-08-22 Nacuity Pharmaceuticals, Inc. Prodrug for the treatment of disease and injury of oxidative stress
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US11883426B2 (en) * 2020-08-08 2024-01-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Treatment for methamphetamine cardiovascular disease
US20220304955A1 (en) * 2021-03-23 2022-09-29 Nacuity Pharmaceuticals, Inc. Treatment of ferroptosis
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