AU2018342784B2 - Rapamycin derivatives - Google Patents
Rapamycin derivatives Download PDFInfo
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- AU2018342784B2 AU2018342784B2 AU2018342784A AU2018342784A AU2018342784B2 AU 2018342784 B2 AU2018342784 B2 AU 2018342784B2 AU 2018342784 A AU2018342784 A AU 2018342784A AU 2018342784 A AU2018342784 A AU 2018342784A AU 2018342784 B2 AU2018342784 B2 AU 2018342784B2
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A61K31/33—Heterocyclic compounds
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US11066416B2 (en) | 2016-02-04 | 2021-07-20 | The Johns Hopkins University | Rapafucin derivative compounds and methods of use thereof |
EP3411032B1 (fr) | 2016-02-04 | 2020-09-30 | The Johns Hopkins University | Rapadocins, inhibiteurs du transporteur équilibrant 1 des nucléosides et leurs utilisations |
CN108697729B (zh) | 2016-02-04 | 2023-05-09 | 约翰霍普金斯大学 | 新型GLUT抑制剂rapaglutin及其用途 |
AR112834A1 (es) | 2017-09-26 | 2019-12-18 | Novartis Ag | Derivados de rapamicina |
JP7381492B2 (ja) | 2018-05-01 | 2023-11-15 | レヴォリューション・メディスンズ,インコーポレイテッド | Mtor阻害剤としてのc26-連結ラパマイシン類似体 |
AU2019262978B2 (en) | 2018-05-01 | 2023-07-13 | Revolution Medicines, Inc. | C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors |
LT3813946T (lt) | 2018-06-15 | 2024-07-10 | Janssen Pharmaceutica Nv | Rapamicino analogai ir jų panaudojimas |
KR102643707B1 (ko) | 2019-01-22 | 2024-03-04 | 에오비안 파마슈티컬스, 인크. | Mtorc 조절제 및 이의 용도 |
KR102497821B1 (ko) * | 2019-08-23 | 2023-02-08 | 이화여자대학교 산학협력단 | 신규 mTOR 억제제 화합물 및 이의 용도 |
KR102486721B1 (ko) * | 2019-08-23 | 2023-01-10 | 이화여자대학교 산학협력단 | 신규 mTOR 억제제 화합물 및 이의 용도 |
TW202126323A (zh) * | 2019-10-01 | 2021-07-16 | 約翰斯赫普金斯大學 | 雷帕弗辛(Rapafucin)衍生化合物及其使用方法 |
EP4069223A4 (fr) | 2019-12-05 | 2023-12-20 | Janssen Pharmaceutica NV | Analogues de la rapamycine et leurs utilisations |
EP4118431A1 (fr) | 2020-03-12 | 2023-01-18 | Heinrich-Heine-Universität Düsseldorf | Inhibition de fkbp1a pour la thérapie du carcinome mammaire triple négatif |
DE102020203224A1 (de) | 2020-03-12 | 2021-09-16 | Heinrich-Heine-Universität Düsseldorf | Inhibition von FKBP1A zur Therapie des Triple-negativen Mammakarzinoms |
KR20230084095A (ko) * | 2020-03-27 | 2023-06-12 | 에오비안 파마슈티컬스, 인크. | Mtorc1 조절제 및 이의 용도 |
WO2022033529A1 (fr) * | 2020-08-12 | 2022-02-17 | 洪明奇 | Utilisation d'un antagoniste de sema3d dans la prévention ou le traitement de maladies neurodégénératives et prolongeant la durée de vie |
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WO2017044720A1 (fr) * | 2015-09-11 | 2017-03-16 | Navitor Pharmaceuticals, Inc. | Analogues de la rapamycine et leurs utilisations |
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KR19990022651A (ko) | 1995-06-07 | 1999-03-25 | 데이비드 엘. 버스테인 | 생물학적 사건에 대한 라파마이신 기재 조절방법 |
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EP3109250A1 (fr) | 2015-06-23 | 2016-12-28 | Synbias Pharma AG | Procede pour la synthese de derives de rapamycine |
CA3061907A1 (fr) | 2017-05-02 | 2018-11-08 | Revolution Medicines, Inc. | Analogues de la rapamycine utilises en tant qu'inhibiteurs de mtor |
AR112834A1 (es) | 2017-09-26 | 2019-12-18 | Novartis Ag | Derivados de rapamicina |
BR112021011325A2 (pt) | 2018-12-18 | 2021-11-16 | Novartis Ag | Derivados de rapamicina |
AU2020250026B2 (en) | 2019-03-26 | 2023-08-10 | Novartis Ag | Isothiazolidine 1,1-dioxide and 1,4-butan sultone containing rapamycin derivatives and uses thereof |
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Patent Citations (3)
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US5985890A (en) * | 1995-06-09 | 1999-11-16 | Novartis Ag | Rapamycin derivatives |
WO2007096174A1 (fr) * | 2006-02-24 | 2007-08-30 | Novartis Ag | Derives de la rapamycine pour le traitement du neuroblastome |
WO2017044720A1 (fr) * | 2015-09-11 | 2017-03-16 | Navitor Pharmaceuticals, Inc. | Analogues de la rapamycine et leurs utilisations |
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