AU2018342089B2 - Novel USP7 inhibitors for treating multiple myeloma - Google Patents
Novel USP7 inhibitors for treating multiple myeloma Download PDFInfo
- Publication number
- AU2018342089B2 AU2018342089B2 AU2018342089A AU2018342089A AU2018342089B2 AU 2018342089 B2 AU2018342089 B2 AU 2018342089B2 AU 2018342089 A AU2018342089 A AU 2018342089A AU 2018342089 A AU2018342089 A AU 2018342089A AU 2018342089 B2 AU2018342089 B2 AU 2018342089B2
- Authority
- AU
- Australia
- Prior art keywords
- alkyl
- compound
- heteroaryl
- cancer
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762563375P | 2017-09-26 | 2017-09-26 | |
| US62/563,375 | 2017-09-26 | ||
| PCT/US2018/052797 WO2019067503A1 (en) | 2017-09-26 | 2018-09-26 | NEW USP7 INHIBITORS FOR THE TREATMENT OF MULTIPLE MYELOMA |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2018342089A1 AU2018342089A1 (en) | 2020-02-27 |
| AU2018342089B2 true AU2018342089B2 (en) | 2024-07-11 |
Family
ID=65903565
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2018342089A Active AU2018342089B2 (en) | 2017-09-26 | 2018-09-26 | Novel USP7 inhibitors for treating multiple myeloma |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11465983B2 (https=) |
| EP (1) | EP3687537A4 (https=) |
| JP (3) | JP7402792B2 (https=) |
| AU (1) | AU2018342089B2 (https=) |
| CA (1) | CA3072353A1 (https=) |
| WO (1) | WO2019067503A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3072353A1 (en) | 2017-09-26 | 2019-04-04 | Dana-Farber Cancer Institute, Inc. | Usp7 inhibitors for treating multiple myeloma |
| JP7508449B2 (ja) * | 2018-10-22 | 2024-07-01 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | Ｕｓｐ７の阻害 |
| MX2021006542A (es) * | 2018-12-06 | 2021-07-07 | Almac Discovery Ltd | Inhibidores de la usp19 para usarse en terapia. |
| EP3965749A4 (en) * | 2019-05-06 | 2023-06-21 | Valo Health, Inc. | ESCAPEMENT OF USP19 |
| EP4110393A1 (en) | 2020-02-28 | 2023-01-04 | Immunologik GmbH | Inhibitors of human deubiquitinases for the treatment of coronaviral infections |
| CN112047933B (zh) * | 2020-10-15 | 2022-06-14 | 郑州大学 | 喹唑啉酮类usp7抑制剂及其制备方法和应用 |
| GB202104097D0 (en) * | 2021-03-24 | 2021-05-05 | Almac Discovery Ltd | Pharmaceutical compounds |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999053924A1 (en) * | 1998-04-17 | 1999-10-28 | Kyowa Hakko Kogyo Co., Ltd. | Analgetic agent |
| WO2007147217A1 (en) * | 2006-06-22 | 2007-12-27 | Prana Biotechnology Limited | Method of treatment of glioma brain tumour |
| EP2565186A1 (en) * | 2011-09-02 | 2013-03-06 | Hybrigenics S.A. | Selective and reversible inhibitors of ubiquitin specific protease 7 |
| WO2016126926A1 (en) * | 2015-02-05 | 2016-08-11 | Forma Therapeutics, Inc. | Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60326436D1 (en) | 2002-03-13 | 2009-04-16 | Janssen Pharmaceutica Nv | Aminoderivate als histone-deacetylase-inhibitoren |
| EP3253765A1 (en) * | 2015-02-05 | 2017-12-13 | Forma Therapeutics, Inc. | Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors |
| US9938300B2 (en) * | 2015-02-05 | 2018-04-10 | Forma Therapeutics, Inc. | Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors |
| GB201612938D0 (en) | 2016-07-26 | 2016-09-07 | Almac Discovery Ltd | Pharmaceutical compounds |
| GB201617758D0 (en) | 2016-10-20 | 2016-12-07 | Almac Discovery Limited | Pharmaceutical compounds |
| CA3072353A1 (en) | 2017-09-26 | 2019-04-04 | Dana-Farber Cancer Institute, Inc. | Usp7 inhibitors for treating multiple myeloma |
| JP7508449B2 (ja) | 2018-10-22 | 2024-07-01 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | Ｕｓｐ７の阻害 |
-
2018
- 2018-09-26 CA CA3072353A patent/CA3072353A1/en active Pending
- 2018-09-26 WO PCT/US2018/052797 patent/WO2019067503A1/en not_active Ceased
- 2018-09-26 JP JP2020515000A patent/JP7402792B2/ja active Active
- 2018-09-26 AU AU2018342089A patent/AU2018342089B2/en active Active
- 2018-09-26 US US16/650,727 patent/US11465983B2/en active Active
- 2018-09-26 EP EP18862773.1A patent/EP3687537A4/en active Pending
-
2022
- 2022-09-02 US US17/902,512 patent/US20230265070A1/en active Pending
-
2023
- 2023-09-01 JP JP2023142246A patent/JP2023164918A/ja active Pending
-
2025
- 2025-12-05 JP JP2025235397A patent/JP2026031721A/ja active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999053924A1 (en) * | 1998-04-17 | 1999-10-28 | Kyowa Hakko Kogyo Co., Ltd. | Analgetic agent |
| WO2007147217A1 (en) * | 2006-06-22 | 2007-12-27 | Prana Biotechnology Limited | Method of treatment of glioma brain tumour |
| EP2565186A1 (en) * | 2011-09-02 | 2013-03-06 | Hybrigenics S.A. | Selective and reversible inhibitors of ubiquitin specific protease 7 |
| WO2016126926A1 (en) * | 2015-02-05 | 2016-08-11 | Forma Therapeutics, Inc. | Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors |
Non-Patent Citations (1)
| Title |
|---|
| Database Registry Chemical Abstracts Service, Columbus, Ohio, Accession No. RN 1381443-96-4, Entered STN: Jul. 4, 2012. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA3072353A1 (en) | 2019-04-04 |
| JP7402792B2 (ja) | 2023-12-21 |
| JP2026031721A (ja) | 2026-02-24 |
| AU2018342089A1 (en) | 2020-02-27 |
| JP2023164918A (ja) | 2023-11-14 |
| EP3687537A4 (en) | 2021-06-16 |
| EP3687537A1 (en) | 2020-08-05 |
| US11465983B2 (en) | 2022-10-11 |
| US20230265070A1 (en) | 2023-08-24 |
| WO2019067503A1 (en) | 2019-04-04 |
| US20200347031A1 (en) | 2020-11-05 |
| JP2020535124A (ja) | 2020-12-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2018342089B2 (en) | Novel USP7 inhibitors for treating multiple myeloma | |
| US12559457B2 (en) | Sulfonamide derivatives for protein degradation | |
| CA3083228A1 (en) | Small molecule degraders that recruit dcaft15 | |
| KR20150091389A (ko) | 글루타미나제의 헤테로사이클릭 억제제에 의한 암 치료 | |
| AU2018346331B2 (en) | Small molecule inhibition of transcription factor SALL4 and uses thereof | |
| AU2019368263B2 (en) | USP7 inhibition | |
| JP2023516645A (ja) | Ｔｅａｄ阻害剤としてのヘテロ二官能性分子 | |
| WO2016150800A1 (en) | Usp7 inhibitor compounds and methods of use | |
| WO2019067530A1 (en) | COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY INTESTINAL DISEASE | |
| EP3989967B1 (en) | Compounds, compositions, and methods for protein degradation | |
| CA3039070A1 (en) | Inhibitors of mtor-deptor interactions and methods of use thereof | |
| WO2023207447A1 (zh) | 吡咯并[2,3-d]嘧啶或吡唑并[3,4-d]嘧啶衍生物及其用途 | |
| US20230312481A1 (en) | Substituted (phthalazin-1-ylmethyl)ureas, substituted n-(phthalazin-1-ylmethyl)amides, and analogues thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |