AU2018312448B2 - 1, 2 - dihydro- 3h- pyrazolo [3, 4 - d] pyrimidin -3 - one analogs - Google Patents

1, 2 - dihydro- 3h- pyrazolo [3, 4 - d] pyrimidin -3 - one analogs Download PDF

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Publication number
AU2018312448B2
AU2018312448B2 AU2018312448A AU2018312448A AU2018312448B2 AU 2018312448 B2 AU2018312448 B2 AU 2018312448B2 AU 2018312448 A AU2018312448 A AU 2018312448A AU 2018312448 A AU2018312448 A AU 2018312448A AU 2018312448 B2 AU2018312448 B2 AU 2018312448B2
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Australia
Prior art keywords
cancer
alkyl
optionally substituted
unsubstituted
compound
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Ceased
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AU2018312448A
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AU2018312448A1 (en
Inventor
Brant Clayton BOREN
Kevin Duane Bunker
Peter Qinhua HUANG
Hui Liu
Sunil Paliwal
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Recurium IP Holdings LLC
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Recurium IP Holdings LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2018312448A 2017-08-01 2018-07-31 1, 2 - dihydro- 3h- pyrazolo [3, 4 - d] pyrimidin -3 - one analogs Ceased AU2018312448B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762539734P 2017-08-01 2017-08-01
US62/539,734 2017-08-01
PCT/US2018/044580 WO2019028008A1 (en) 2017-08-01 2018-07-31 1,2-DIHYDRO-3H-PYRAZOLO [3,4-D] PYRIMIDIN-3-ONE ANALOGUES

Publications (2)

Publication Number Publication Date
AU2018312448A1 AU2018312448A1 (en) 2020-02-13
AU2018312448B2 true AU2018312448B2 (en) 2022-09-15

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AU2018312448A Ceased AU2018312448B2 (en) 2017-08-01 2018-07-31 1, 2 - dihydro- 3h- pyrazolo [3, 4 - d] pyrimidin -3 - one analogs

Country Status (16)

Country Link
US (2) US11124518B2 (OSRAM)
EP (1) EP3661918B1 (OSRAM)
JP (1) JP7203816B2 (OSRAM)
KR (1) KR20200034781A (OSRAM)
CN (1) CN111094253B (OSRAM)
AR (1) AR112774A1 (OSRAM)
AU (1) AU2018312448B2 (OSRAM)
BR (1) BR112020002104A2 (OSRAM)
CA (1) CA3071405A1 (OSRAM)
ES (1) ES2980537T3 (OSRAM)
IL (1) IL272262A (OSRAM)
MX (1) MX2020001235A (OSRAM)
RU (1) RU2020105058A (OSRAM)
SG (1) SG11202000789WA (OSRAM)
TW (1) TW201910335A (OSRAM)
WO (1) WO2019028008A1 (OSRAM)

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AU2018347307A1 (en) 2017-10-09 2020-04-23 Nuvation Bio Inc. Heterocyclic compounds and uses thereof
EP3694861A4 (en) * 2017-10-09 2021-05-19 Nuvation Bio Inc. HETEROCYCLIC COMPOUNDS AND USES THEREOF
CA3088997A1 (en) * 2018-02-28 2019-09-06 The Regents Of The University Of Colorado, A Body Corporate Wee1 kinase inhibitors and methods of treating cancer using the same
RS66798B1 (sr) * 2018-03-09 2025-06-30 Recurium Ip Holdings Llc Supstituisani 1,2-dihidro-3h-pirazolo[3,4-d]pirimidin-3-oni
CN110872296B (zh) * 2018-08-31 2023-05-23 上海弘翊生物科技有限公司 一种二氢异吲哚-1H-吡唑并[3,4-d]嘧啶酮化合物、其制备方法和应用
EP3952876A4 (en) * 2019-04-09 2023-04-19 Nuvation Bio Inc. HETEROCYCLIC COMPOUNDS AND THEIR USES
WO2020210380A1 (en) * 2019-04-09 2020-10-15 Nuvation Bio Inc. Heterocyclic compounds and uses thereof
CN113939296A (zh) * 2019-04-09 2022-01-14 诺维逊生物股份有限公司 杂环化合物及其用途
WO2020210320A1 (en) * 2019-04-11 2020-10-15 Recurium Ip Holdings, Llc Substituted l,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-ones
KR20220042127A (ko) 2019-06-28 2022-04-04 상하이 파마슈티컬스 홀딩 컴퍼니 리미티드 피라졸로피리미딘 화합물, 그의 제조 방법 및 그의 응용
CN112142748B (zh) * 2019-06-28 2023-07-04 上海医药集团股份有限公司 一种吡唑酮并嘧啶类化合物、其制备方法及应用
CN112442049A (zh) * 2019-09-03 2021-03-05 微境生物医药科技(上海)有限公司 作为Wee1抑制剂的嘧啶衍生物
KR20220103748A (ko) 2019-11-15 2022-07-22 리커리엄 아이피 홀딩스, 엘엘씨 3차 알코올의 키랄 합성
EP4069235A4 (en) * 2019-12-20 2024-01-10 Recurium IP Holdings, LLC ASSOCIATIONS
NZ793883A (en) * 2020-05-15 2025-11-28 Recurium Ip Holdings Llc Mono- and combination therapies
WO2021254389A1 (zh) * 2020-06-17 2021-12-23 微境生物医药科技(上海)有限公司 作为Wee-1抑制剂的吡唑并[3，4-d]嘧啶-3-酮衍生物
CN114805357B (zh) * 2021-01-21 2023-12-19 四川大学 一种靶向setdb1-ttd的小分子抑制剂及其制药用途
KR20240004539A (ko) * 2021-04-30 2024-01-11 위겐 바이오메더슨 테크널러지 (상하이) 컴퍼니 리미티드 Wee-1 억제제로서의 축합 고리 화합물, 그를 위한 제조 방법 및 그의 용도
CN117751122A (zh) * 2021-08-11 2024-03-22 微境生物医药科技(上海)有限公司 作为Wee-1抑制剂的1,2-二氢-3H-吡唑[3,4-d]嘧啶-3-酮化合物
CN117940430B (zh) * 2021-09-22 2025-10-31 微境生物医药科技(上海)有限公司 作为Wee-1抑制剂的1,2-二氢-3H-吡唑[3,4-d]嘧啶-3-酮化合物
WO2023166080A1 (en) 2022-03-01 2023-09-07 Step Pharma S.A.S. Combination treatments comprising a ctps1 inhibitor and a wee1 inhibitor

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006074985A1 (en) * 2005-01-14 2006-07-20 Janssen Pharmaceutica N.V. 5-membered annelated heterocyclic pyrimidines as kinase inhibitors
WO2007126122A1 (en) * 2006-04-27 2007-11-08 Banyu Pharmaceutical Co., Ltd. Dihydropyrazolopyrimidinone derivatives
EP2213673A1 (en) * 2007-10-23 2010-08-04 Banyu Pharmaceutical Co., Ltd. Pyridone-substituted-dihydropyrazolopyrimidinone derivative
WO2018011569A1 (en) * 2016-07-12 2018-01-18 Almac Discovery Limited Wee-1 inhibiting pyrazolopyrimidinone compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS58956B1 (sr) * 2012-09-10 2019-08-30 Principia Biopharma Inc Jedinjenja pirazolopirimidina kao inhibitori kinaze

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006074985A1 (en) * 2005-01-14 2006-07-20 Janssen Pharmaceutica N.V. 5-membered annelated heterocyclic pyrimidines as kinase inhibitors
WO2007126122A1 (en) * 2006-04-27 2007-11-08 Banyu Pharmaceutical Co., Ltd. Dihydropyrazolopyrimidinone derivatives
EP2213673A1 (en) * 2007-10-23 2010-08-04 Banyu Pharmaceutical Co., Ltd. Pyridone-substituted-dihydropyrazolopyrimidinone derivative
US8329711B2 (en) * 2007-10-23 2012-12-11 Msd K.K. Pyridone-substituted-dihydropyrazolopyrimidinone derivative
WO2018011569A1 (en) * 2016-07-12 2018-01-18 Almac Discovery Limited Wee-1 inhibiting pyrazolopyrimidinone compounds

Also Published As

Publication number Publication date
EP3661918B1 (en) 2024-05-08
WO2019028008A1 (en) 2019-02-07
RU2020105058A3 (OSRAM) 2021-11-17
JP7203816B2 (ja) 2023-01-13
RU2020105058A (ru) 2021-09-02
AU2018312448A1 (en) 2020-02-13
ES2980537T3 (es) 2024-10-01
IL272262A (en) 2020-03-31
CA3071405A1 (en) 2019-02-07
TW201910335A (zh) 2019-03-16
MX2020001235A (es) 2020-07-20
AR112774A1 (es) 2019-12-11
EP3661918A1 (en) 2020-06-10
CN111094253A (zh) 2020-05-01
US20210317124A1 (en) 2021-10-14
EP3661918C0 (en) 2024-05-08
CN111094253B (zh) 2023-08-29
US11124518B2 (en) 2021-09-21
SG11202000789WA (en) 2020-02-27
US20200157112A1 (en) 2020-05-21
KR20200034781A (ko) 2020-03-31
BR112020002104A2 (pt) 2020-08-04
EP3661918A4 (en) 2021-05-12
JP2020529993A (ja) 2020-10-15

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