AU2018297214B2 - A peripherally-restricted dual-acting kappa and delta opioid agonist for analgesia in pain states involving the inflammatory response - Google Patents

A peripherally-restricted dual-acting kappa and delta opioid agonist for analgesia in pain states involving the inflammatory response Download PDF

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Publication number
AU2018297214B2
AU2018297214B2 AU2018297214A AU2018297214A AU2018297214B2 AU 2018297214 B2 AU2018297214 B2 AU 2018297214B2 AU 2018297214 A AU2018297214 A AU 2018297214A AU 2018297214 A AU2018297214 A AU 2018297214A AU 2018297214 B2 AU2018297214 B2 AU 2018297214B2
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Australia
Prior art keywords
pain
compound
inflammation
cancer
inflammatory response
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AU2018297214A
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AU2018297214A1 (en
Inventor
Craig HARTRICK
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Caventure Drug Discovery Inc
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Caventure Drug Discovery Inc
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Dowels (AREA)
AU2018297214A 2017-07-06 2018-06-22 A peripherally-restricted dual-acting kappa and delta opioid agonist for analgesia in pain states involving the inflammatory response Active AU2018297214B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762529285P 2017-07-06 2017-07-06
US62/529,285 2017-07-06
PCT/US2018/038936 WO2019010014A1 (en) 2017-07-06 2018-06-22 OPIOID KAPPA AND DELTA AGONIST WITH DOUBLE ACTION LIMITED TO PERIPHERY FOR ANALGESIA IN PAIN CONDITIONS INVOLVING INFLAMMATORY RESPONSE

Publications (2)

Publication Number Publication Date
AU2018297214A1 AU2018297214A1 (en) 2020-01-16
AU2018297214B2 true AU2018297214B2 (en) 2022-09-01

Family

ID=64950308

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018297214A Active AU2018297214B2 (en) 2017-07-06 2018-06-22 A peripherally-restricted dual-acting kappa and delta opioid agonist for analgesia in pain states involving the inflammatory response

Country Status (10)

Country Link
US (2) US11185551B2 (enExample)
EP (1) EP3649132B1 (enExample)
JP (1) JP7233741B2 (enExample)
KR (1) KR20200026962A (enExample)
CN (2) CN111278831A (enExample)
AU (1) AU2018297214B2 (enExample)
CA (1) CA3067398A1 (enExample)
IL (1) IL271772A (enExample)
SG (1) SG11201912036XA (enExample)
WO (1) WO2019010014A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3222543A1 (en) * 2021-06-07 2022-12-15 Uwm Research Foundation, Inc. Use of substituted 5-(4-methyl-6-phenyl-4h-benzo[f]imidazo[1,5-a][1,4] diazepin-3-yl)-1,2,4-oxadiazoles in the treatment of inflammatory conditions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2180852C2 (ru) 1994-12-12 2002-03-27 Омерос Медикл Системс, Инк. Ингибирующий раствор и способ подавления боли, воспаления или спазма
US20030008807A1 (en) * 2001-06-14 2003-01-09 The Regents Of The University Of California Novel signaling pathway for the production of inflammatory pain and neuropathy
US20050152905A1 (en) * 2002-08-22 2005-07-14 Omoigui Osemwota S. Method of biochemical treatment of persistent pain
WO2015114660A1 (en) 2014-01-24 2015-08-06 Cadila Healtchare Limited Novel heterobicyclic compounds as kappa opioid agonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Shainell O. Eans et al., JOURNAL OF MEDICINAL CHEMISTRY, US, (2015-06-04), vol. 58, no. 12, doi:10.1021/jm501637c, ISSN 0022-2623, pages 4905 - 4917 *

Also Published As

Publication number Publication date
JP7233741B2 (ja) 2023-03-07
EP3649132B1 (en) 2023-12-27
CN111278831A (zh) 2020-06-12
SG11201912036XA (en) 2020-01-30
EP3649132A1 (en) 2020-05-13
US20210161912A1 (en) 2021-06-03
AU2018297214A1 (en) 2020-01-16
EP3649132A4 (en) 2021-04-07
US20220288089A1 (en) 2022-09-15
IL271772A (en) 2020-02-27
WO2019010014A1 (en) 2019-01-10
JP2020525548A (ja) 2020-08-27
CN116440140A (zh) 2023-07-18
US11185551B2 (en) 2021-11-30
KR20200026962A (ko) 2020-03-11
CA3067398A1 (en) 2019-01-10

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DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE INVENTION TITLE TO READ A PERIPHERALLY-RESTRICTED DUAL-ACTING KAPPA AND DELTA OPIOID AGONIST FOR ANALGESIA IN PAIN STATES INVOLVING THE INFLAMMATORY RESPONSE

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