CA3067398A1 - A peripherally-restricted dual-acting kappa and delta opioid agonist for analgesia in pain states involving the inflammatory response - Google Patents
A peripherally-restricted dual-acting kappa and delta opioid agonist for analgesia in pain states involving the inflammatory response Download PDFInfo
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- CA3067398A1 CA3067398A1 CA3067398A CA3067398A CA3067398A1 CA 3067398 A1 CA3067398 A1 CA 3067398A1 CA 3067398 A CA3067398 A CA 3067398A CA 3067398 A CA3067398 A CA 3067398A CA 3067398 A1 CA3067398 A1 CA 3067398A1
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Organic Chemistry (AREA)
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- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Dowels (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762529285P | 2017-07-06 | 2017-07-06 | |
| US62/529,285 | 2017-07-06 | ||
| PCT/US2018/038936 WO2019010014A1 (en) | 2017-07-06 | 2018-06-22 | OPIOID KAPPA AND DELTA AGONIST WITH DOUBLE ACTION LIMITED TO PERIPHERY FOR ANALGESIA IN PAIN CONDITIONS INVOLVING INFLAMMATORY RESPONSE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3067398A1 true CA3067398A1 (en) | 2019-01-10 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3067398A Pending CA3067398A1 (en) | 2017-07-06 | 2018-06-22 | A peripherally-restricted dual-acting kappa and delta opioid agonist for analgesia in pain states involving the inflammatory response |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11185551B2 (enExample) |
| EP (1) | EP3649132B1 (enExample) |
| JP (1) | JP7233741B2 (enExample) |
| KR (1) | KR20200026962A (enExample) |
| CN (2) | CN111278831A (enExample) |
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| WO2002102232A2 (en) * | 2001-06-14 | 2002-12-27 | The Regents Of The University Of California | A novel signaling pathway for the production of inflammatory pain and neuropathy |
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| EA201691489A1 (ru) | 2014-01-24 | 2016-12-30 | Кадила Хелзкэр Лимитед | Новые гетероциклические соединения в качестве агонистов каппа-опиодиов |
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| IL271772A (en) | 2020-02-27 |
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| EP3649132A1 (en) | 2020-05-13 |
| JP7233741B2 (ja) | 2023-03-07 |
| KR20200026962A (ko) | 2020-03-11 |
| EP3649132B1 (en) | 2023-12-27 |
| SG11201912036XA (en) | 2020-01-30 |
| WO2019010014A1 (en) | 2019-01-10 |
| JP2020525548A (ja) | 2020-08-27 |
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