AU2017351906B2 - Functional derivative compounds of alanine and proline amino acids and pharmaceutical composition comprising same - Google Patents

Functional derivative compounds of alanine and proline amino acids and pharmaceutical composition comprising same Download PDF

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Publication number
AU2017351906B2
AU2017351906B2 AU2017351906A AU2017351906A AU2017351906B2 AU 2017351906 B2 AU2017351906 B2 AU 2017351906B2 AU 2017351906 A AU2017351906 A AU 2017351906A AU 2017351906 A AU2017351906 A AU 2017351906A AU 2017351906 B2 AU2017351906 B2 AU 2017351906B2
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benzyl
compound
formula
oxy
hydrogen
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AU2017351906A1 (en
Inventor
Yong-Sun Bahn
Ji Won Choi
Bo Ko JANG
Yong Koo Kang
Siwon KIM
Jong-Seung Lee
Kyung-Tae Lee
Ae Nim Pae
Jong Hyun Park
Ki Duk Park
Seul Ki YEON
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Amtixbio Co Ltd
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Amtixbio Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P3/00—Fungicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AU2017351906A 2016-10-28 2017-10-30 Functional derivative compounds of alanine and proline amino acids and pharmaceutical composition comprising same Active AU2017351906B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1020160142266A KR20180046730A (ko) 2016-10-28 2016-10-28 알라닌 및 프롤린 아미노산의 기능적 유도체 화합물 및 이를 포함하는 약학적 조성물
KR10-2016-0142266 2016-10-28
PCT/KR2017/012108 WO2018080269A1 (ko) 2016-10-28 2017-10-30 알라닌 및 프롤린 아미노산의 기능적 유도체 화합물 및 이를 포함하는 약학적 조성물

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AU2017351906A1 AU2017351906A1 (en) 2019-06-13
AU2017351906B2 true AU2017351906B2 (en) 2022-03-10

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AU2017351906A Active AU2017351906B2 (en) 2016-10-28 2017-10-30 Functional derivative compounds of alanine and proline amino acids and pharmaceutical composition comprising same

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US (5) US20200199065A1 (https=)
EP (1) EP3533782A4 (https=)
JP (1) JP7061317B2 (https=)
KR (3) KR20180046730A (https=)
CN (2) CN110325509B (https=)
AU (1) AU2017351906B2 (https=)
BR (1) BR112019008577B1 (https=)
CA (1) CA3041985C (https=)
WO (1) WO2018080269A1 (https=)

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Publication number Priority date Publication date Assignee Title
IL289445B2 (en) 2019-06-25 2025-03-01 Amtixbio Co Ltd Derivative of an aminoalkanoic acid containing a biphenyl group and an antifungal pharmaceutical preparation containing it
EP4349329A4 (en) * 2021-06-01 2025-09-03 Amtixbio Co Ltd BENZYLOXY-BENZYLAMINYL AMINO ACID DERIVATIVE FOR ADJUSTING TSLP/TSLPR SIGNAL TRANSMISSION
CN117486755B (zh) * 2023-11-02 2025-09-02 成都大学 一种香芹酚季铵盐类衍生物及其合成方法和应用

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WO1998006265A2 (en) * 1996-08-09 1998-02-19 Buckman Laboratories International, Inc. Treatment of fungal infections using a combination of an anti-fungal compound and an n-alkyl-heterocyclic compound, especially n-dodecyl-morpholine
GB0009055D0 (en) * 2000-04-13 2000-05-31 Novartis Ag Organic compounds
WO2005033079A1 (ja) * 2003-09-30 2005-04-14 Eisai Co., Ltd. ヘテロ環化合物を含有する新規な抗真菌剤
BR112013009580B1 (pt) * 2010-10-21 2018-06-19 Bayer Intellectual Property Gmbh Composto de fómrula (i), composição fungicida e método para controlar fungos fitopatogênicos
JP6301842B2 (ja) * 2012-12-18 2018-03-28 Ｅａファーマ株式会社 複素環アミド誘導体及びそれを含有する医薬
JP6413200B2 (ja) * 2013-10-25 2018-10-31 日本曹達株式会社 アミノピリジン誘導体および農園芸用殺菌剤

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Title
CAS Reg No: 1575941-18-2; STN Entry date 28 Mar 2014; Pentanamide, 2-amino-N-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-4-methyl-, (2S)- *
CAS Reg No: 1580202-66-9; STN Entry date 4 Apr 2014; Hexanamide, 2-amino-N-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]- *
CAS Reg No: 1580733-69-2; STN Entry date 6 Apr 2014; 2-Pyrrolidinecarboxamide, N-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-, hydrochloride (1:1), (2S)- *
CAS Reg No: 1589285-51-7; STN Entry date 23 Apr 2014; Pentanamide, 2-amino-4-methyl-N-[[4-(phenylmethoxy)phenyl]methyl]-, (2S)- *
CAS Reg No: 1591307-28-6; STN Entry date 27 Apr 2014; Butanamide, 2-amino-N-[[4-(phenylmethoxy)phenyl]methyl]- *
CAS Reg No: 1595469-06-9; STN Entry date 1 May 2014; Pentanamide, 2-amino-N-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-4-methyl- *
CAS Reg No: 1604227-58-8; STN Entry date 13 May 2014; Hexanamide, 2-amino-N-[[4-(phenylmethoxy)phenyl]methyl]- *
CAS Reg No: 1607080-90-9 ; STN Entry date 19 May 2014; Pentanamide, 2-amino-N-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]- *
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CAS RN 1606791-76-7; STN entry date 19 May 2014; 2-amino-N-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-pentanamide hydrochloride (1:1) *
CAS RN 1606837-37-9; STN entry date 19 May 2014; 2-amino-N-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-butanamide hydrochloride (1:1) *
CAS RN 1606837-63-1; STN entry date 19 May 2014; (2S)-2-amino-N-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-butanamide hydrochloride (1:1) *
CAS RN 1607121-83-4; STN entry date 19 May 2014; 2-amino-N-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-butanamide *
CAS RN 1607122-04-2; STN entry date 19 May 2014; (2S)-2-amino-N-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl-butanamide *
CAS RN 1940950-96-8; STN entry date 28 June 2016; N-[[4-[(3-methylphenyl)methoxy]phenyl]methyl]-2-pyrrolidinecarboxamide *
CAS RN 576306-00-7; STN entry date 19 May 2014; N-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]-3-pyrrolidinecarboxamide *
LIU, K. K.-C. et al., "Orally Active and Brain Permeable Proline Amides as Highly Selective 5HT2c Agonists for the Treatment of Obesity", Bioorganic & medicinal chemistry letters, 2010, vol. 20, no. 7, pages 2365-2369 *

Also Published As

Publication number Publication date
KR20190016946A (ko) 2019-02-19
US20250034085A1 (en) 2025-01-30
US20250034083A1 (en) 2025-01-30
EP3533782A4 (en) 2020-06-10
CA3041985A1 (en) 2018-05-03
JP7061317B2 (ja) 2022-04-28
KR102099980B1 (ko) 2020-04-13
US20250034082A1 (en) 2025-01-30
WO2018080269A1 (ko) 2018-05-03
AU2017351906A1 (en) 2019-06-13
BR112019008577B1 (pt) 2023-11-28
CA3041985C (en) 2024-01-16
US20250034084A1 (en) 2025-01-30
JP2019535814A (ja) 2019-12-12
KR20200066610A (ko) 2020-06-10
CN116836083A (zh) 2023-10-03
BR112019008577A2 (pt) 2019-09-17
KR20180046730A (ko) 2018-05-09
EP3533782A1 (en) 2019-09-04
US20200199065A1 (en) 2020-06-25
CN110325509A (zh) 2019-10-11
CN110325509B (zh) 2024-02-02

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