CN110325509B - 丙氨酸及脯氨酸氨基酸的功能性衍生物化合物及包含其的药学组合物 - Google Patents

丙氨酸及脯氨酸氨基酸的功能性衍生物化合物及包含其的药学组合物 Download PDF

Info

Publication number
CN110325509B
CN110325509B CN201780067547.5A CN201780067547A CN110325509B CN 110325509 B CN110325509 B CN 110325509B CN 201780067547 A CN201780067547 A CN 201780067547A CN 110325509 B CN110325509 B CN 110325509B
Authority
CN
China
Prior art keywords
benzyl
compound
oxy
chemical formula
trifluoromethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201780067547.5A
Other languages
English (en)
Chinese (zh)
Other versions
CN110325509A (zh
Inventor
朴起德
潘镛善
李钟胜
李炅泰
裴爱宁
严瑟基
姜用求
朴永玄
金仕源
张博科
崔志元
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amtixbio Co Ltd
Original Assignee
Amtixbio Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amtixbio Co Ltd filed Critical Amtixbio Co Ltd
Priority to CN202310670949.1A priority Critical patent/CN116836083A/zh
Publication of CN110325509A publication Critical patent/CN110325509A/zh
Application granted granted Critical
Publication of CN110325509B publication Critical patent/CN110325509B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P3/00—Fungicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Agronomy & Crop Science (AREA)
  • Dentistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CN201780067547.5A 2016-10-28 2017-10-30 丙氨酸及脯氨酸氨基酸的功能性衍生物化合物及包含其的药学组合物 Active CN110325509B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202310670949.1A CN116836083A (zh) 2016-10-28 2017-10-30 丙氨酸及脯氨酸氨基酸的功能性衍生物化合物及包含其的药学组合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1020160142266A KR20180046730A (ko) 2016-10-28 2016-10-28 알라닌 및 프롤린 아미노산의 기능적 유도체 화합물 및 이를 포함하는 약학적 조성물
KR10-2016-0142266 2016-10-28
PCT/KR2017/012108 WO2018080269A1 (ko) 2016-10-28 2017-10-30 알라닌 및 프롤린 아미노산의 기능적 유도체 화합물 및 이를 포함하는 약학적 조성물

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202310670949.1A Division CN116836083A (zh) 2016-10-28 2017-10-30 丙氨酸及脯氨酸氨基酸的功能性衍生物化合物及包含其的药学组合物

Publications (2)

Publication Number Publication Date
CN110325509A CN110325509A (zh) 2019-10-11
CN110325509B true CN110325509B (zh) 2024-02-02

Family

ID=62025284

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201780067547.5A Active CN110325509B (zh) 2016-10-28 2017-10-30 丙氨酸及脯氨酸氨基酸的功能性衍生物化合物及包含其的药学组合物
CN202310670949.1A Pending CN116836083A (zh) 2016-10-28 2017-10-30 丙氨酸及脯氨酸氨基酸的功能性衍生物化合物及包含其的药学组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202310670949.1A Pending CN116836083A (zh) 2016-10-28 2017-10-30 丙氨酸及脯氨酸氨基酸的功能性衍生物化合物及包含其的药学组合物

Country Status (9)

Country Link
US (5) US20200199065A1 (https=)
EP (1) EP3533782A4 (https=)
JP (1) JP7061317B2 (https=)
KR (3) KR20180046730A (https=)
CN (2) CN110325509B (https=)
AU (1) AU2017351906B2 (https=)
BR (1) BR112019008577B1 (https=)
CA (1) CA3041985C (https=)
WO (1) WO2018080269A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL289445B2 (en) 2019-06-25 2025-03-01 Amtixbio Co Ltd Derivative of an aminoalkanoic acid containing a biphenyl group and an antifungal pharmaceutical preparation containing it
EP4349329A4 (en) * 2021-06-01 2025-09-03 Amtixbio Co Ltd BENZYLOXY-BENZYLAMINYL AMINO ACID DERIVATIVE FOR ADJUSTING TSLP/TSLPR SIGNAL TRANSMISSION
CN117486755B (zh) * 2023-11-02 2025-09-02 成都大学 一种香芹酚季铵盐类衍生物及其合成方法和应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005033079A1 (ja) * 2003-09-30 2005-04-14 Eisai Co., Ltd. ヘテロ環化合物を含有する新規な抗真菌剤
KR20130129203A (ko) * 2010-10-21 2013-11-27 바이엘 인텔렉쳐 프로퍼티 게엠베하 Ｎ-벤질 헤테로시클릭 카르복사미드
WO2015060378A1 (ja) * 2013-10-25 2015-04-30 日本曹達株式会社 アミノピリジン誘導体および農園芸用殺菌剤
CN104854086A (zh) * 2012-12-18 2015-08-19 味之素株式会社 杂环酰胺衍生物和含有其的药物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998006265A2 (en) * 1996-08-09 1998-02-19 Buckman Laboratories International, Inc. Treatment of fungal infections using a combination of an anti-fungal compound and an n-alkyl-heterocyclic compound, especially n-dodecyl-morpholine
GB0009055D0 (en) * 2000-04-13 2000-05-31 Novartis Ag Organic compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005033079A1 (ja) * 2003-09-30 2005-04-14 Eisai Co., Ltd. ヘテロ環化合物を含有する新規な抗真菌剤
KR20130129203A (ko) * 2010-10-21 2013-11-27 바이엘 인텔렉쳐 프로퍼티 게엠베하 Ｎ-벤질 헤테로시클릭 카르복사미드
CN104854086A (zh) * 2012-12-18 2015-08-19 味之素株式会社 杂环酰胺衍生物和含有其的药物
WO2015060378A1 (ja) * 2013-10-25 2015-04-30 日本曹達株式会社 アミノピリジン誘導体および農園芸用殺菌剤

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
/.ACS REGISTRY DATABASE.《STN》.2016, *
ACS REGISTRY DATABASE;/;《STN》;20160927;全文 *
Liu, Kevin K.-C.等.Orally active and brain permeable proline amides as highly selective 5HT2c agonists for the treatment of obesity.《Bioorganic & Medicinal Chemistry Letters》.2010,第20卷(第7期),第2365-2369页. *
Orally active and brain permeable proline amides as highly selective 5HT2c agonists for the treatment of obesity;Liu, Kevin K.-C.等;《Bioorganic & Medicinal Chemistry Letters》;20100125;第20卷(第7期);第2365-2369页 *

Also Published As

Publication number Publication date
KR20190016946A (ko) 2019-02-19
US20250034085A1 (en) 2025-01-30
US20250034083A1 (en) 2025-01-30
EP3533782A4 (en) 2020-06-10
AU2017351906B2 (en) 2022-03-10
CA3041985A1 (en) 2018-05-03
JP7061317B2 (ja) 2022-04-28
KR102099980B1 (ko) 2020-04-13
US20250034082A1 (en) 2025-01-30
WO2018080269A1 (ko) 2018-05-03
AU2017351906A1 (en) 2019-06-13
BR112019008577B1 (pt) 2023-11-28
CA3041985C (en) 2024-01-16
US20250034084A1 (en) 2025-01-30
JP2019535814A (ja) 2019-12-12
KR20200066610A (ko) 2020-06-10
CN116836083A (zh) 2023-10-03
BR112019008577A2 (pt) 2019-09-17
KR20180046730A (ko) 2018-05-09
EP3533782A1 (en) 2019-09-04
US20200199065A1 (en) 2020-06-25
CN110325509A (zh) 2019-10-11

Similar Documents

Publication Publication Date Title
US20250034085A1 (en) Composition and methods for preventing or treating phytopathogenic fungal infection
CN114051496B (zh) 将联苯基引入新型氨基烷酸的衍生物化合物及包含其的抗真菌药学组合物
US20100168421A1 (en) A new peptide deformylase inhibitor compound and manufacturing process thereof
RU2690161C1 (ru) 3,5-Замещенные производные тиазолидин-2,4-диона, обладающие противомикробной активностью
PT98685A (pt) Processo de preparacao de inibidores da renina por exemplo derivados de 6-ciclo-hexil-4(s)-hidroxi-2-(s)-isopropil-hexanamida e de composicoes farmaceuticas que os contem
RU2826219C2 (ru) Новое производное аминоалкановой кислоты, содержащее бифенильную группу, и содержащая его противогрибковая фармацевтическая композиция
EP2185525B1 (fr) Dérivés de pyrazole 3,5-carboxylates, leur préparation et leur application en thérapeutique
HK40060177A (en) Derivative compound introducing biphenyl group into novel aminoalkanoic acid and antifungal pharmaceutical composition comprising same
KR20230103336A (ko) 바이오필름 생성을 억제하는 신규한 항진균용 조성물
WO2023128033A1 (ko) 감염성 진균의 바이오필름 생성을 억제하는 신규한 항진균용 조성물

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant