AU2017348434B2 - Peripheral modifications on pocket-redesigned vancomycin analogs synergistically improve antimicrobial potency and durability - Google Patents

Peripheral modifications on pocket-redesigned vancomycin analogs synergistically improve antimicrobial potency and durability Download PDF

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Publication number
AU2017348434B2
AU2017348434B2 AU2017348434A AU2017348434A AU2017348434B2 AU 2017348434 B2 AU2017348434 B2 AU 2017348434B2 AU 2017348434 A AU2017348434 A AU 2017348434A AU 2017348434 A AU2017348434 A AU 2017348434A AU 2017348434 B2 AU2017348434 B2 AU 2017348434B2
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AU
Australia
Prior art keywords
vancomycin
compound
ala
pharmaceutically acceptable
acceptable salt
Prior art date
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Ceased
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AU2017348434A
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English (en)
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AU2017348434A1 (en
Inventor
Dale L. Boger
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Scripps Research Institute
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Scripps Research Institute
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Publication of AU2017348434A1 publication Critical patent/AU2017348434A1/en
Application granted granted Critical
Publication of AU2017348434B2 publication Critical patent/AU2017348434B2/en
Ceased legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2017348434A 2016-10-31 2017-10-31 Peripheral modifications on pocket-redesigned vancomycin analogs synergistically improve antimicrobial potency and durability Ceased AU2017348434B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662415191P 2016-10-31 2016-10-31
US62/415,191 2016-10-31
PCT/US2017/059289 WO2018081797A1 (en) 2016-10-31 2017-10-31 Peripheral modifications on pocket-redesigned vancomycin analogs synergistically improve antimicrobial potency and durability

Publications (2)

Publication Number Publication Date
AU2017348434A1 AU2017348434A1 (en) 2019-05-16
AU2017348434B2 true AU2017348434B2 (en) 2021-10-07

Family

ID=62024092

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017348434A Ceased AU2017348434B2 (en) 2016-10-31 2017-10-31 Peripheral modifications on pocket-redesigned vancomycin analogs synergistically improve antimicrobial potency and durability

Country Status (6)

Country Link
US (1) US10934326B2 (enExample)
EP (1) EP3532483A4 (enExample)
JP (1) JP7104424B2 (enExample)
AU (1) AU2017348434B2 (enExample)
CA (1) CA3042039C (enExample)
WO (1) WO2018081797A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL270686B (en) 2017-05-22 2022-09-01 Insmed Inc Derivatives of glycopeptides and their uses
JP2023522104A (ja) * 2020-04-20 2023-05-26 ザ スクリプス リサーチ インスティテュート グアニジン修飾ｃ末端バンコマイシン化合物、組成物及び方法
CN117069794B (zh) * 2023-06-20 2024-02-13 广州中医药大学(广州中医药研究院) 一种糖肽类抗生素荧光探针化合物及其制备方法与应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998000153A1 (en) * 1996-06-28 1998-01-08 Eli Lilly And Company Amides

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060091049A (ko) 2002-08-30 2006-08-17 케이.유.루벤 리서치 앤드 디벨럽먼트 글리코펩티드 항생제 및 그것의 반합성 유도체 및 항바이러스제로서의 그것의 사용
EP1818340A4 (en) 2004-11-29 2009-02-25 Univ Nagoya Nat Univ Corp ANTIBIOTIC MONOMERS GLYCOPEPTIDE DERIVATIVES
EP2688580A4 (en) * 2011-03-24 2015-03-25 Seachaid Pharmaceuticals Inc DERIVATIVES OF VANCOMYCIN
WO2013072838A1 (en) * 2011-11-14 2013-05-23 Jawaharlal Nehru Centre For Advanced Scientific Research Cationic antibacterial composition
US10577395B2 (en) 2014-07-10 2020-03-03 The Scripps Research Institute N-(hydrophobe-substituted) vancosaminyl [Ψ-[C(=NH) NH] Tpg4] vancomycin and [Ψ-[CH2NH]Tpg4] vancomycin
CN107619433B (zh) * 2016-07-15 2023-03-17 上海来益生物药物研究开发中心有限责任公司 糖肽类衍生物及其药学可接受的盐、制备方法和应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998000153A1 (en) * 1996-06-28 1998-01-08 Eli Lilly And Company Amides

Also Published As

Publication number Publication date
CA3042039C (en) 2023-09-26
CA3042039A1 (en) 2018-05-03
EP3532483A4 (en) 2020-09-02
AU2017348434A1 (en) 2019-05-16
JP7104424B2 (ja) 2022-07-21
WO2018081797A1 (en) 2018-05-03
US20200071359A1 (en) 2020-03-05
US10934326B2 (en) 2021-03-02
EP3532483A1 (en) 2019-09-04
JP2019534289A (ja) 2019-11-28

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired