CA3042039C - Peripheral modifications on pocket-redesigned vancomycin analogs synergistically improve antimicrobial potency and durability - Google Patents
Peripheral modifications on pocket-redesigned vancomycin analogs synergistically improve antimicrobial potency and durability Download PDFInfo
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- CA3042039C CA3042039C CA3042039A CA3042039A CA3042039C CA 3042039 C CA3042039 C CA 3042039C CA 3042039 A CA3042039 A CA 3042039A CA 3042039 A CA3042039 A CA 3042039A CA 3042039 C CA3042039 C CA 3042039C
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- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical class S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- DKVBOUDTNWVDEP-NJCHZNEYSA-N teicoplanin aglycone Chemical class N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)OC=1C=C3C=C(C=1O)OC1=CC=C(C=C1Cl)C[C@H](C(=O)N1)NC([C@H](N)C=4C=C(O5)C(O)=CC=4)=O)C(=O)[C@@H]2NC(=O)[C@@H]3NC(=O)[C@@H]1C1=CC5=CC(O)=C1 DKVBOUDTNWVDEP-NJCHZNEYSA-N 0.000 description 1
- 238000011191 terminal modification Methods 0.000 description 1
- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 238000000825 ultraviolet detection Methods 0.000 description 1
- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662415191P | 2016-10-31 | 2016-10-31 | |
| US62/415,191 | 2016-10-31 | ||
| PCT/US2017/059289 WO2018081797A1 (en) | 2016-10-31 | 2017-10-31 | Peripheral modifications on pocket-redesigned vancomycin analogs synergistically improve antimicrobial potency and durability |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA3042039A1 CA3042039A1 (en) | 2018-05-03 |
| CA3042039C true CA3042039C (en) | 2023-09-26 |
Family
ID=62024092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3042039A Active CA3042039C (en) | 2016-10-31 | 2017-10-31 | Peripheral modifications on pocket-redesigned vancomycin analogs synergistically improve antimicrobial potency and durability |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10934326B2 (enExample) |
| EP (1) | EP3532483A4 (enExample) |
| JP (1) | JP7104424B2 (enExample) |
| AU (1) | AU2017348434B2 (enExample) |
| CA (1) | CA3042039C (enExample) |
| WO (1) | WO2018081797A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL270686B (en) | 2017-05-22 | 2022-09-01 | Insmed Inc | Derivatives of glycopeptides and their uses |
| JP2023522104A (ja) * | 2020-04-20 | 2023-05-26 | ザ スクリプス リサーチ インスティテュート | グアニジン修飾ｃ末端バンコマイシン化合物、組成物及び方法 |
| CN117069794B (zh) * | 2023-06-20 | 2024-02-13 | 广州中医药大学(广州中医药研究院) | 一种糖肽类抗生素荧光探针化合物及其制备方法与应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5919756A (en) | 1996-06-28 | 1999-07-06 | Eli Lilly And Company | Amides |
| KR20060091049A (ko) | 2002-08-30 | 2006-08-17 | 케이.유.루벤 리서치 앤드 디벨럽먼트 | 글리코펩티드 항생제 및 그것의 반합성 유도체 및 항바이러스제로서의 그것의 사용 |
| EP1818340A4 (en) | 2004-11-29 | 2009-02-25 | Univ Nagoya Nat Univ Corp | ANTIBIOTIC MONOMERS GLYCOPEPTIDE DERIVATIVES |
| EP2688580A4 (en) * | 2011-03-24 | 2015-03-25 | Seachaid Pharmaceuticals Inc | DERIVATIVES OF VANCOMYCIN |
| WO2013072838A1 (en) * | 2011-11-14 | 2013-05-23 | Jawaharlal Nehru Centre For Advanced Scientific Research | Cationic antibacterial composition |
| US10577395B2 (en) | 2014-07-10 | 2020-03-03 | The Scripps Research Institute | N-(hydrophobe-substituted) vancosaminyl [Ψ-[C(=NH) NH] Tpg4] vancomycin and [Ψ-[CH2NH]Tpg4] vancomycin |
| CN107619433B (zh) * | 2016-07-15 | 2023-03-17 | 上海来益生物药物研究开发中心有限责任公司 | 糖肽类衍生物及其药学可接受的盐、制备方法和应用 |
-
2017
- 2017-10-31 WO PCT/US2017/059289 patent/WO2018081797A1/en not_active Ceased
- 2017-10-31 AU AU2017348434A patent/AU2017348434B2/en not_active Ceased
- 2017-10-31 CA CA3042039A patent/CA3042039C/en active Active
- 2017-10-31 EP EP17864216.1A patent/EP3532483A4/en not_active Withdrawn
- 2017-10-31 JP JP2019522839A patent/JP7104424B2/ja active Active
- 2017-10-31 US US16/344,300 patent/US10934326B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA3042039A1 (en) | 2018-05-03 |
| EP3532483A4 (en) | 2020-09-02 |
| AU2017348434A1 (en) | 2019-05-16 |
| JP7104424B2 (ja) | 2022-07-21 |
| WO2018081797A1 (en) | 2018-05-03 |
| US20200071359A1 (en) | 2020-03-05 |
| AU2017348434B2 (en) | 2021-10-07 |
| US10934326B2 (en) | 2021-03-02 |
| EP3532483A1 (en) | 2019-09-04 |
| JP2019534289A (ja) | 2019-11-28 |
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