AU2017338846B2 - Co-stimulatory domains for use in genetically-modified cells - Google Patents

Co-stimulatory domains for use in genetically-modified cells Download PDF

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AU2017338846B2
AU2017338846B2 AU2017338846A AU2017338846A AU2017338846B2 AU 2017338846 B2 AU2017338846 B2 AU 2017338846B2 AU 2017338846 A AU2017338846 A AU 2017338846A AU 2017338846 A AU2017338846 A AU 2017338846A AU 2017338846 B2 AU2017338846 B2 AU 2017338846B2
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cells
car
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AU2017338846A1 (en
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Derek Jantz
Daniel T. Macleod
Aaron Martin
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Precision Biosciences Inc
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Precision Biosciences Inc
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Priority to AU2023202905A priority patent/AU2023202905A1/en
Priority to AU2025200717A priority patent/AU2025200717A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A61K40/4211—CD19 or B4
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12Y502/01—Cis-trans-Isomerases (5.2.1)
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
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AU2017338846A 2016-10-04 2017-10-04 Co-stimulatory domains for use in genetically-modified cells Active AU2017338846B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2020286323A AU2020286323B2 (en) 2016-10-04 2020-12-11 Co-stimulatory domains for use in genetically-modified cells
AU2023202905A AU2023202905A1 (en) 2016-10-04 2023-05-10 Co-stimulatory domains for use in genetically-modified cells
AU2025200717A AU2025200717A1 (en) 2016-10-04 2025-02-03 Co-stimulatory domains for use in genetically-modified cells

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662403880P 2016-10-04 2016-10-04
US62/403,880 2016-10-04
US201762501475P 2017-05-04 2017-05-04
US62/501,475 2017-05-04
US201762556199P 2017-09-08 2017-09-08
US62/556,199 2017-09-08
PCT/US2017/055133 WO2018067697A1 (en) 2016-10-04 2017-10-04 Co-stimulatory domains for use in genetically-modified cells

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AU2017338846B2 true AU2017338846B2 (en) 2020-09-24

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AU2020286323A Active AU2020286323B2 (en) 2016-10-04 2020-12-11 Co-stimulatory domains for use in genetically-modified cells
AU2023202905A Abandoned AU2023202905A1 (en) 2016-10-04 2023-05-10 Co-stimulatory domains for use in genetically-modified cells
AU2025200717A Pending AU2025200717A1 (en) 2016-10-04 2025-02-03 Co-stimulatory domains for use in genetically-modified cells

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AU2023202905A Abandoned AU2023202905A1 (en) 2016-10-04 2023-05-10 Co-stimulatory domains for use in genetically-modified cells
AU2025200717A Pending AU2025200717A1 (en) 2016-10-04 2025-02-03 Co-stimulatory domains for use in genetically-modified cells

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US (4) US11286291B2 (enExample)
EP (3) EP4115951A1 (enExample)
JP (4) JP6887492B6 (enExample)
AU (4) AU2017338846B2 (enExample)
CA (1) CA3039014A1 (enExample)
DK (2) DK3523326T3 (enExample)
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