AU2017261685B2 - Methods for classifying patients with a solid cancer - Google Patents

Methods for classifying patients with a solid cancer Download PDF

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AU2017261685B2
AU2017261685B2 AU2017261685A AU2017261685A AU2017261685B2 AU 2017261685 B2 AU2017261685 B2 AU 2017261685B2 AU 2017261685 A AU2017261685 A AU 2017261685A AU 2017261685 A AU2017261685 A AU 2017261685A AU 2017261685 B2 AU2017261685 B2 AU 2017261685B2
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cells
density
cancer
biological markers
tumor
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AU2017261685A1 (en
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Jérôme GALON
Bernhard Mlecnik
Franck Pages
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Assistance Publique Hopitaux de Paris APHP
Institut National de la Sante et de la Recherche Medicale INSERM
Sorbonne Universite
Universite Paris Cite
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Assistance Publique Hopitaux de Paris APHP
Institut National de la Sante et de la Recherche Medicale INSERM
Sorbonne Universite
Universite Paris Cite
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Assigned to INSERM (Institut National de la Santé et de la Recherche Médicale), ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS, SORBONNE UNIVERSITE, Universite De Paris reassignment INSERM (Institut National de la Santé et de la Recherche Médicale) Request for Assignment Assignors: ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS, INSERM (Institut National de la Santé et de la Recherche Médicale), SORBONNE UNIVERSITE, UNIVERSITE PARIS DESCARTES, UNIVERSITÉ PARIS DIDEROT - PARIS 7
Assigned to INSERM (Institut National de la Santé et de la Recherche Médicale), ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS, SORBONNE UNIVERSITE, UNIVERSITÉ PARIS CITÉ reassignment INSERM (Institut National de la Santé et de la Recherche Médicale) Amend patent request/document other than specification (104) Assignors: ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS, INSERM (Institut National de la Santé et de la Recherche Médicale), SORBONNE UNIVERSITE, Universite De Paris
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • C—CHEMISTRY; METALLURGY
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6862—Ligase chain reaction [LCR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57419—Specifically defined cancers of colon
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
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    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
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    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

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  • Engineering & Computer Science (AREA)
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  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
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  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
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  • Analytical Chemistry (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
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  • Wood Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
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  • Databases & Information Systems (AREA)
  • Data Mining & Analysis (AREA)
  • Primary Health Care (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2017261685A 2016-05-09 2017-05-09 Methods for classifying patients with a solid cancer Active AU2017261685B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16305536.1 2016-05-09
EP16305536 2016-05-09
PCT/EP2017/061089 WO2017194556A1 (en) 2016-05-09 2017-05-09 Methods for classifying patients with a solid cancer

Publications (2)

Publication Number Publication Date
AU2017261685A1 AU2017261685A1 (en) 2018-11-15
AU2017261685B2 true AU2017261685B2 (en) 2023-09-07

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US (1) US20190309369A1 (enExample)
EP (1) EP3455631B1 (enExample)
JP (3) JP7281903B2 (enExample)
KR (1) KR102245021B1 (enExample)
CN (2) CN109690314B (enExample)
AU (1) AU2017261685B2 (enExample)
ES (1) ES2808004T3 (enExample)
MX (1) MX393482B (enExample)
PL (1) PL3455631T3 (enExample)
RU (1) RU2745730C2 (enExample)
SG (1) SG11201809317VA (enExample)
WO (1) WO2017194556A1 (enExample)
ZA (1) ZA201807020B (enExample)

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EP3659110A1 (en) 2017-07-24 2020-06-03 Ventana Medical Systems, Inc. Methods and systems for evaluation of immune cell infiltrate in tumor samples
DK3746790T3 (da) * 2018-01-31 2023-12-11 Ventana Med Syst Inc Fremgangsmåder og systemer til evaluering af immuncelleinfiltrat i kolorektal stadie III cancer
FR3079617B1 (fr) 2018-03-29 2023-12-22 Office National Detude Et De Rech Aerospatiales Onera Methode de detection de cellules presentant au moins une anomalie dans un echantillon cytologique
WO2020245155A1 (en) 2019-06-03 2020-12-10 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for modulating a treatment regimen
CN110988324B (zh) * 2019-11-29 2021-08-24 广州市雷德医学检验实验室有限公司 免疫状态确定系统、方法、装置及存储介质
CN111257563B (zh) * 2020-01-22 2022-08-23 广州泛恩生物科技有限公司 Cxcl13检测剂在制备预测免疫治疗效果的试剂盒中的用途
CN111999503B (zh) * 2020-05-28 2022-05-20 首都医科大学附属北京地坛医院 一组用于预测急性病毒性呼吸道传染病重症化的标志物及其应用和试剂盒
EP4172628A1 (en) * 2020-06-30 2023-05-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapy and radical surgery
CN113174439B (zh) * 2021-03-30 2022-06-28 中国医学科学院肿瘤医院 一种基于免疫基因对评分体系在预测非小细胞肺癌患者免疫治疗效果中的应用
US20240210404A1 (en) * 2021-04-27 2024-06-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the risk of lymph node metastasis and/or recurrence of patients suffering from a t1 cancer treated by endoscopic resection
KR20220155554A (ko) * 2021-05-13 2022-11-23 주식회사 센트릭스바이오 항-CD300c 항체를 이용한 병용 요법
CA3245129A1 (en) 2022-03-17 2023-09-21 Univ Paris Cite METHODS FOR PREDICTING RESPONSE TO IMMUNOTHERAPEUTIC TREATMENT IN A CANCER PATIENT
EP4533092A1 (en) * 2022-06-03 2025-04-09 Universita'Degli Studi di Roma "La Sapienza" Method for determining the prognostic score in patients with metastatic renal carcinoma
CN115058504B (zh) * 2022-07-14 2025-07-04 广州医科大学 膀胱癌th17 cd4+t细胞亚群及其特征基因与应用
CN115747331B (zh) * 2022-09-22 2023-08-25 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） 用于预测鼻咽癌预后的三级淋巴结构成分标志物组合、系统及应用
TWI826081B (zh) * 2022-10-28 2023-12-11 臺北醫學大學 癌症進展評估方法及其系統
CN117476097B (zh) * 2023-10-25 2024-06-07 中山大学附属第六医院 一种基于三级淋巴结构特征基因的结直肠癌预后和治疗反应预测模型及其构建方法和应用
CN119685476A (zh) * 2024-05-29 2025-03-25 深圳湾实验室 一种与癌症预后相关的基因标志物及其应用
CN119291200A (zh) * 2024-10-16 2025-01-10 华中科技大学同济医学院附属协和医院 一种用于检测cxcr4+cd8+t细胞用于预测肿瘤免疫治疗的检测试剂盒
CN120259410B (zh) * 2025-06-05 2025-09-23 北京大橡科技有限公司 基于双Panel多重生物标志物分析的肿瘤免疫响应可能性的评分方法

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JP7281903B2 (ja) 2023-05-26
MX2018013744A (es) 2019-08-16
KR102245021B1 (ko) 2021-04-26
BR112018072993A8 (pt) 2022-11-08
EP3455631A1 (en) 2019-03-20
PL3455631T3 (pl) 2021-04-06
JP2022027788A (ja) 2022-02-14
ES2808004T3 (es) 2021-02-25
RU2018143409A (ru) 2020-06-10
RU2745730C2 (ru) 2021-03-31
US20190309369A1 (en) 2019-10-10
SG11201809317VA (en) 2018-11-29
BR112018072993A2 (pt) 2019-03-06
AU2017261685A1 (en) 2018-11-15
WO2017194556A1 (en) 2017-11-16
EP3455631B1 (en) 2020-06-24
JP7654318B2 (ja) 2025-04-01
MX393482B (es) 2025-03-24
CN115198018A (zh) 2022-10-18
CN109690314A (zh) 2019-04-26
ZA201807020B (en) 2020-05-27
RU2018143409A3 (enExample) 2020-06-29
KR20190016025A (ko) 2019-02-15
JP2019516979A (ja) 2019-06-20
JP2024019551A (ja) 2024-02-09
CN109690314B (zh) 2022-08-02

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