AU2017253560B2 - Conjugates comprising RIPK2 inhibitors - Google Patents
Conjugates comprising RIPK2 inhibitors Download PDFInfo
- Publication number
- AU2017253560B2 AU2017253560B2 AU2017253560A AU2017253560A AU2017253560B2 AU 2017253560 B2 AU2017253560 B2 AU 2017253560B2 AU 2017253560 A AU2017253560 A AU 2017253560A AU 2017253560 A AU2017253560 A AU 2017253560A AU 2017253560 B2 AU2017253560 B2 AU 2017253560B2
- Authority
- AU
- Australia
- Prior art keywords
- dimethyl
- tert
- methyl
- oxy
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 C*CC*(C[C@@]1*(CC(*(CC2(C)C)c3c2*(N)c(*)c(Cc2ccc(C)cc2)c3)=O)C[C@@](*)*(C)C1)C(C)C Chemical compound C*CC*(C[C@@]1*(CC(*(CC2(C)C)c3c2*(N)c(*)c(Cc2ccc(C)cc2)c3)=O)C[C@@](*)*(C)C1)C(C)C 0.000 description 3
- DJQXZAAVKICXIW-LLVKDONJSA-N CC(C)(C)OC(N1C[C@H](COc(cn2)cnc2Cl)OCC1)=O Chemical compound CC(C)(C)OC(N1C[C@H](COc(cn2)cnc2Cl)OCC1)=O DJQXZAAVKICXIW-LLVKDONJSA-N 0.000 description 1
- NNPSDWFWOCDUBT-MUUNZHRXSA-N CC(C)(C)OC(N1C[C@H](COc2cnc(N3CCN(CCCOc4cc5ncnc(Nc6c(C)c(C)n[nH]6)c5cc4S(C(C)(C)C)(=O)=O)CC3)nc2)OCC1)=O Chemical compound CC(C)(C)OC(N1C[C@H](COc2cnc(N3CCN(CCCOc4cc5ncnc(Nc6c(C)c(C)n[nH]6)c5cc4S(C(C)(C)C)(=O)=O)CC3)nc2)OCC1)=O NNPSDWFWOCDUBT-MUUNZHRXSA-N 0.000 description 1
- KBEDEHFCOANLGZ-UHFFFAOYSA-N CC(C)(C)S(c(c(OCCCN(CC1)CCN1C(C(C=C)=C)=O)c1)cc2c1ncnc2Nc1c(C)c(C)n[nH]1)(=O)=O Chemical compound CC(C)(C)S(c(c(OCCCN(CC1)CCN1C(C(C=C)=C)=O)c1)cc2c1ncnc2Nc1c(C)c(C)n[nH]1)(=O)=O KBEDEHFCOANLGZ-UHFFFAOYSA-N 0.000 description 1
- QKGBTFOMPQNGCH-UHFFFAOYSA-N CC(C)(C)S(c1cc2c(Nc3c(C)c(C)n[nH]3)ncnc2cc1OCCCN(CC1)CCN1c(nc1)ccc1C(O)=O)(=O)=O Chemical compound CC(C)(C)S(c1cc2c(Nc3c(C)c(C)n[nH]3)ncnc2cc1OCCCN(CC1)CCN1c(nc1)ccc1C(O)=O)(=O)=O QKGBTFOMPQNGCH-UHFFFAOYSA-N 0.000 description 1
- ZBJVEMQGMKMUOL-UHFFFAOYSA-N CC(C)(C)S(c1cc2c(Nc3c(C)c(C)n[nH]3)ncnc2cc1OCCN(CC1)CCN1c1ncc(C(O)=O)nc1)(=O)=O Chemical compound CC(C)(C)S(c1cc2c(Nc3c(C)c(C)n[nH]3)ncnc2cc1OCCN(CC1)CCN1c1ncc(C(O)=O)nc1)(=O)=O ZBJVEMQGMKMUOL-UHFFFAOYSA-N 0.000 description 1
- YNKMPUBEOHCOQO-UHFFFAOYSA-N CCCCOc1cc2ncnc(Nc3c(C)c(C)n[nH]3)c2cc1S(C(C)(C)C)(=O)=O Chemical compound CCCCOc1cc2ncnc(Nc3c(C)c(C)n[nH]3)c2cc1S(C(C)(C)C)(=O)=O YNKMPUBEOHCOQO-UHFFFAOYSA-N 0.000 description 1
- BRFRSFUWNSAKTN-VMBXARNFSA-N C[C@H](C1)N(C[C@@H](C2)N(CC(N(CC3(C)C)c4c3ncc(Cc3ccc(C)cc3)c4)=O)C[C@@H](C)N2C(OC(C)(C)C)=O)CCN1C(c1ccc(N2CCN(CCCOc3cc4ncnc(Nc5c(C)c(C)n[nH]5)c4cc3S(C(C)(C)C)(=O)=O)CC2)nc1)=C Chemical compound C[C@H](C1)N(C[C@@H](C2)N(CC(N(CC3(C)C)c4c3ncc(Cc3ccc(C)cc3)c4)=O)C[C@@H](C)N2C(OC(C)(C)C)=O)CCN1C(c1ccc(N2CCN(CCCOc3cc4ncnc(Nc5c(C)c(C)n[nH]5)c4cc3S(C(C)(C)C)(=O)=O)CC2)nc1)=C BRFRSFUWNSAKTN-VMBXARNFSA-N 0.000 description 1
- KXISFLRDVPJYHS-NFBKMPQASA-N C[C@H](CN(CC(N(CC1(C)C)C(C=C2Cc3ccc(C)cc3)=C1NC2=O)=O)[C@@H](CO)C1)N1C(OC(C)(C)C)=O Chemical compound C[C@H](CN(CC(N(CC1(C)C)C(C=C2Cc3ccc(C)cc3)=C1NC2=O)=O)[C@@H](CO)C1)N1C(OC(C)(C)C)=O KXISFLRDVPJYHS-NFBKMPQASA-N 0.000 description 1
- PNEVDUPLZBINTR-OAGXKRJSSA-N C[C@H](CN(CC(N(CC1(C)C)c2c1ncc(Cc(cc1)ccc1F)c2)=O)[C@H](C1)C#CN(CC2)[C@H](C)CN2C(NC2C)=NC=C2OCCOc2cc3ncnc(Nc4c(C)c(C)n[nH]4)c3cc2S(C(C)(C)C)(=O)=O)N1C(OC(C)(C)C)=O Chemical compound C[C@H](CN(CC(N(CC1(C)C)c2c1ncc(Cc(cc1)ccc1F)c2)=O)[C@H](C1)C#CN(CC2)[C@H](C)CN2C(NC2C)=NC=C2OCCOc2cc3ncnc(Nc4c(C)c(C)n[nH]4)c3cc2S(C(C)(C)C)(=O)=O)N1C(OC(C)(C)C)=O PNEVDUPLZBINTR-OAGXKRJSSA-N 0.000 description 1
- UMEKYHJOPBYLPD-CLIADVIRSA-N C[C@H]1NC(C[C@H](C2)N(C)CCN2I)CN(CC(N(CC2(C)C)c3c2ncc(Cc(cc2)ccc2F)c3)=O)C1 Chemical compound C[C@H]1NC(C[C@H](C2)N(C)CCN2I)CN(CC(N(CC2(C)C)c3c2ncc(Cc(cc2)ccc2F)c3)=O)C1 UMEKYHJOPBYLPD-CLIADVIRSA-N 0.000 description 1
- CWZDXAGKRYGKPI-LDJSFYOUSA-N C[C@H]1NC[C@H](CN(CC2)C(C)CN2I)N(CC(N2c3cc(Cc(cc4)ccc4F)cnc3C(C)(C)C2)=O)C1 Chemical compound C[C@H]1NC[C@H](CN(CC2)C(C)CN2I)N(CC(N2c3cc(Cc(cc4)ccc4F)cnc3C(C)(C)C2)=O)C1 CWZDXAGKRYGKPI-LDJSFYOUSA-N 0.000 description 1
- FHXRDTNNYDGAJE-CJFMBICVSA-N C[C@H]1NC[C@H](CN(CC2)CCC2I)N(CC(N(CC2(C)C)c3c2ncc(Cc(cc2)ccc2F)c3)=O)C1 Chemical compound C[C@H]1NC[C@H](CN(CC2)CCC2I)N(CC(N(CC2(C)C)c3c2ncc(Cc(cc2)ccc2F)c3)=O)C1 FHXRDTNNYDGAJE-CJFMBICVSA-N 0.000 description 1
- KHYIKINNQSQUOQ-PDXXHEQOSA-N C[C@H]1NC[C@H](CN2C[C@H](C)OCC2)N(CC(N(CCC2)[C@@H]2c2nc(C(c(cc3)ccc3F)=O)c[s]2)=O)C1 Chemical compound C[C@H]1NC[C@H](CN2C[C@H](C)OCC2)N(CC(N(CCC2)[C@@H]2c2nc(C(c(cc3)ccc3F)=O)c[s]2)=O)C1 KHYIKINNQSQUOQ-PDXXHEQOSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/11—Protein-serine/threonine kinases (2.7.11)
- C12Y207/11001—Non-specific serine/threonine protein kinase (2.7.11.1), i.e. casein kinase or checkpoint kinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/10—Protein-tyrosine kinases (2.7.10)
- C12Y207/10002—Non-specific protein-tyrosine kinase (2.7.10.2), i.e. spleen tyrosine kinase
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662324944P | 2016-04-20 | 2016-04-20 | |
| US62/324,944 | 2016-04-20 | ||
| PCT/EP2017/059090 WO2017182418A1 (en) | 2016-04-20 | 2017-04-18 | Conjugates comprising ripk2 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2017253560A1 AU2017253560A1 (en) | 2018-11-08 |
| AU2017253560B2 true AU2017253560B2 (en) | 2019-03-21 |
Family
ID=58548715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2017253560A Ceased AU2017253560B2 (en) | 2016-04-20 | 2017-04-18 | Conjugates comprising RIPK2 inhibitors |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10781205B2 (enExample) |
| EP (1) | EP3445759A1 (enExample) |
| JP (1) | JP2019514878A (enExample) |
| KR (1) | KR20180135038A (enExample) |
| CN (1) | CN109311867A (enExample) |
| AU (1) | AU2017253560B2 (enExample) |
| BR (1) | BR112018071408A2 (enExample) |
| CA (1) | CA3020792A1 (enExample) |
| RU (1) | RU2018134981A (enExample) |
| WO (1) | WO2017182418A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201506872D0 (en) * | 2015-04-22 | 2015-06-03 | Ge Oil & Gas Uk Ltd | Novel compounds |
| FI3500299T3 (fi) | 2016-08-19 | 2024-02-14 | Beigene Switzerland Gmbh | Tsanubrutinibin yhdistelmä cd20-tai pd-1-vasta-aineen kanssa käytettäväksi syövän hoidossa |
| US11597768B2 (en) | 2017-06-26 | 2023-03-07 | Beigene, Ltd. | Immunotherapy for hepatocellular carcinoma |
| US11786529B2 (en) | 2017-11-29 | 2023-10-17 | Beigene Switzerland Gmbh | Treatment of indolent or aggressive B-cell lymphomas using a combination comprising BTK inhibitors |
| WO2019238817A1 (en) * | 2018-06-13 | 2019-12-19 | University Of Dundee | Bifunctional molecules for targeting rpn11 |
| US11639354B2 (en) | 2018-07-31 | 2023-05-02 | Fimecs, Inc. | Heterocyclic compound |
| WO2020043122A1 (zh) * | 2018-08-28 | 2020-03-05 | 南京明德新药研发有限公司 | 作为rip2激酶抑制剂的喹唑啉类衍生物 |
| EP4671268A2 (en) | 2019-03-21 | 2025-12-31 | Lonza Sales AG | METHOD FOR PREPARING EXTRACELLULAR VESICLES |
| EP3941528A1 (en) | 2019-03-21 | 2022-01-26 | Codiak BioSciences, Inc. | Extracellular vesicle conjugates and uses thereof |
| JP7764027B2 (ja) | 2019-07-31 | 2025-11-05 | ファイメクス株式会社 | 複素環化合物 |
| JP2021024787A (ja) | 2019-07-31 | 2021-02-22 | ファイメクス株式会社 | 複素環化合物 |
| WO2021237100A1 (en) | 2020-05-21 | 2021-11-25 | Codiak Biosciences, Inc. | Methods of targeting extracellular vesicles to lung |
| US20240241020A1 (en) | 2020-09-23 | 2024-07-18 | Lonza Sales Ag | Process for preparing extracellular vesicles |
| IL313509A (en) | 2021-12-30 | 2024-08-01 | Beigene Switzerland Gmbh | Reduction of proton tyrosine kinase (btk) by fusing btk inhibitors with an e3 ligase ligand and methods of use |
| EP4578856A1 (en) * | 2022-09-30 | 2025-07-02 | Ubience Inc. | Heterocyclic compound |
| WO2024240858A1 (en) | 2023-05-23 | 2024-11-28 | Valerio Therapeutics | Protac molecules directed against dna damage repair system and uses thereof |
| AU2024281173A1 (en) | 2023-05-31 | 2025-12-04 | Beone Medicines I Gmbh | Compounds for the degradation of egfr kinase |
| WO2025092821A1 (zh) * | 2023-11-01 | 2025-05-08 | 成都赜灵生物医药科技有限公司 | 喹唑啉衍生物类ripk2抑制剂及其用途 |
| WO2025126115A1 (en) | 2023-12-13 | 2025-06-19 | Beigene Switzerland Gmbh | Degradation of irak4 by conjugation of irak4 inhibitors with e3 ligase ligands and methods of use |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013025958A1 (en) * | 2011-08-18 | 2013-02-21 | Glaxo Group Limited | Amino quinazolines as kinase inhibitors |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20080951A1 (es) | 2006-08-02 | 2008-09-11 | Novartis Ag | DERIVADOS DE 2-OXO-ETIL-AMINO-PROPIONAMIDA-PIRROLIDIN-2-IL-SUSTITUIDOS COMO INHIBIDORES DEL ENLACE DE LA PROTEINA Smac AL INHIBIDOR DE LA PROTEINA DE APOPTOSIS |
| PT2139490E (pt) | 2007-04-13 | 2014-10-08 | Univ Michigan | Miméticos bicíclicos diazo de smac e utilizações destes |
| US9750729B2 (en) * | 2008-05-16 | 2017-09-05 | Dana-Farber Cancer Institute, Inc. | Immunomodulation by IAP inhibitors |
| KR20120048008A (ko) | 2009-08-12 | 2012-05-14 | 노파르티스 아게 | 아폽토시스 단백질의 억제제의 고체 경구 제제 및 결정질 형태 |
| US20130053375A1 (en) | 2010-05-07 | 2013-02-28 | Glaxo Group Limited | Amino-quinolines as kinase inhibitors |
| UY33549A (es) | 2010-08-10 | 2012-01-31 | Glaxo Group Ltd | Quinolil aminas como agentes inhibidores de las quinasas |
| JP6026441B2 (ja) * | 2011-03-04 | 2016-11-16 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | キナーゼ阻害剤としてのアミノキノリン |
| GB201106817D0 (en) * | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compound |
| WO2013106643A2 (en) | 2012-01-12 | 2013-07-18 | Yale University | Compounds & methods for the enhanced degradation of targeted proteins & other polypeptides by an e3 ubiquitin ligase |
| JP6247298B2 (ja) | 2012-08-23 | 2017-12-13 | ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン | Ｉａｐタンパク質の二価阻害薬およびそれを用いた治療方法 |
| TW201425307A (zh) | 2012-09-13 | 2014-07-01 | Glaxosmithkline Llc | 作為激酶抑制劑之胺基－喹啉類 |
| EP2897949B1 (en) | 2012-09-18 | 2018-01-10 | Bristol-Myers Squibb Company | Iap antagonists |
| WO2014055461A1 (en) | 2012-10-02 | 2014-04-10 | Bristol-Myers Squibb Company | Iap antagonists |
| GB201218850D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218864D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218862D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| WO2014090709A1 (en) | 2012-12-11 | 2014-06-19 | F. Hoffmann-La Roche Ag | Dimeric compounds |
| KR101335240B1 (ko) | 2012-12-13 | 2013-11-29 | 전호건 | 수평 연속 방식의 탄화장치 |
| ES2654100T3 (es) * | 2013-02-21 | 2018-02-12 | Glaxosmithkline Intellectual Property Development Limited | Quinazolinas como inhibidores de quinasa |
| GB201311888D0 (en) * | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| GB201311891D0 (en) * | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| CN109336883B (zh) | 2013-12-20 | 2022-06-14 | 阿斯特克斯治疗有限公司 | 双环杂环化合物及其治疗用途 |
| GB201506872D0 (en) * | 2015-04-22 | 2015-06-03 | Ge Oil & Gas Uk Ltd | Novel compounds |
| GB201506871D0 (en) * | 2015-04-22 | 2015-06-03 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
-
2017
- 2017-04-18 US US16/094,564 patent/US10781205B2/en not_active Expired - Fee Related
- 2017-04-18 BR BR112018071408A patent/BR112018071408A2/pt not_active Application Discontinuation
- 2017-04-18 RU RU2018134981A patent/RU2018134981A/ru not_active Application Discontinuation
- 2017-04-18 WO PCT/EP2017/059090 patent/WO2017182418A1/en not_active Ceased
- 2017-04-18 AU AU2017253560A patent/AU2017253560B2/en not_active Ceased
- 2017-04-18 EP EP17717721.9A patent/EP3445759A1/en not_active Withdrawn
- 2017-04-18 CN CN201780036566.1A patent/CN109311867A/zh active Pending
- 2017-04-18 JP JP2018555185A patent/JP2019514878A/ja active Pending
- 2017-04-18 CA CA3020792A patent/CA3020792A1/en not_active Abandoned
- 2017-04-18 KR KR1020187033631A patent/KR20180135038A/ko not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013025958A1 (en) * | 2011-08-18 | 2013-02-21 | Glaxo Group Limited | Amino quinazolines as kinase inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| CA3020792A1 (en) | 2017-10-26 |
| JP2019514878A (ja) | 2019-06-06 |
| CN109311867A (zh) | 2019-02-05 |
| US10781205B2 (en) | 2020-09-22 |
| AU2017253560A1 (en) | 2018-11-08 |
| KR20180135038A (ko) | 2018-12-19 |
| US20190119271A1 (en) | 2019-04-25 |
| EP3445759A1 (en) | 2019-02-27 |
| WO2017182418A1 (en) | 2017-10-26 |
| RU2018134981A (ru) | 2020-05-20 |
| BR112018071408A2 (pt) | 2019-02-05 |
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