AU2017247006B2 - Radiotherapy improvements - Google Patents

Radiotherapy improvements Download PDF

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Publication number
AU2017247006B2
AU2017247006B2 AU2017247006A AU2017247006A AU2017247006B2 AU 2017247006 B2 AU2017247006 B2 AU 2017247006B2 AU 2017247006 A AU2017247006 A AU 2017247006A AU 2017247006 A AU2017247006 A AU 2017247006A AU 2017247006 B2 AU2017247006 B2 AU 2017247006B2
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AU
Australia
Prior art keywords
individual
tumours
irradiated
radiotherapy
tumour
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2017247006A
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English (en)
Other versions
AU2017247006A1 (en
Inventor
Graham Kelly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noxopharm Ltd
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Noxopharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/AU2016/050674 external-priority patent/WO2017173474A1/en
Application filed by Noxopharm Ltd filed Critical Noxopharm Ltd
Publication of AU2017247006A1 publication Critical patent/AU2017247006A1/en
Application granted granted Critical
Publication of AU2017247006B2 publication Critical patent/AU2017247006B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • A61K31/366Lactones having six-membered rings, e.g. delta-lactones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/382Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2017247006A 2016-04-06 2017-04-06 Radiotherapy improvements Ceased AU2017247006B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662318946P 2016-04-06 2016-04-06
US62/318,946 2016-04-06
AUPCT/AU2016/050674 2016-07-28
PCT/AU2016/050674 WO2017173474A1 (en) 2016-04-06 2016-07-28 Improvements in cancer treatment
US201762461559P 2017-02-21 2017-02-21
US62/461,559 2017-02-21
PCT/AU2017/050299 WO2017173496A1 (en) 2016-04-06 2017-04-06 Radiotherapy improvements

Publications (2)

Publication Number Publication Date
AU2017247006A1 AU2017247006A1 (en) 2018-11-01
AU2017247006B2 true AU2017247006B2 (en) 2022-05-12

Family

ID=60000154

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017247006A Ceased AU2017247006B2 (en) 2016-04-06 2017-04-06 Radiotherapy improvements

Country Status (6)

Country Link
US (2) US11229703B2 (enExample)
EP (1) EP3439642A4 (enExample)
JP (1) JP2019513826A (enExample)
AU (1) AU2017247006B2 (enExample)
CA (1) CA3058492A1 (enExample)
WO (1) WO2017173496A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2017247006B2 (en) * 2016-04-06 2022-05-12 Noxopharm Limited Radiotherapy improvements
JP2023512214A (ja) 2020-01-28 2023-03-24 リフレクション メディカル, インコーポレイテッド 放射性核種および外部ビーム放射線療法の共同最適化

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005049008A1 (en) * 2003-11-19 2005-06-02 Novogen Research Pty Ltd Combinational radiotherapy and chemotherapy compositions and methods
WO2006032086A1 (en) * 2004-09-21 2006-03-30 Novogen Research Pty Ltd Chroman derivatives, medicaments and use in therapy
WO2015069562A1 (en) * 2013-11-07 2015-05-14 Humanetics Corporation Genistein cancer treatment regimen maximizing cancer radiation therapy benefits

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO203996A0 (en) * 1996-08-30 1996-09-26 Novogen Research Pty Ltd Therapeutic uses
AUPQ008299A0 (en) 1999-04-30 1999-05-27 G.J. Consultants Pty Ltd Isoflavone metabolites
US20090233999A1 (en) * 1999-09-06 2009-09-17 Novogen Research Pty Ltd Compositions and therapeutic methods involving isoflavones and analogues thereof
AUPQ266199A0 (en) * 1999-09-06 1999-09-30 Novogen Research Pty Ltd Compositions and therapeutic methods involving isoflavones and analogues thereof
AUPR363301A0 (en) * 2001-03-08 2001-04-05 Novogen Research Pty Ltd Dimeric isoflavones
US8178123B2 (en) 2001-08-29 2012-05-15 Femina Pharma Incorporated Method for augmentation of intraepithelial and systemic exposure of therapeutic agents having substrate activity for cytochrome P450 enzymes and membrane efflux systems following vaginal and oral cavity administration
AUPR846401A0 (en) * 2001-10-25 2001-11-15 Novogen Research Pty Ltd 6-Hydroxy isoflavones, derivatives and medicaments involving same
MXPA04009896A (es) 2002-04-09 2005-06-17 Novogen Res Pty Ltd Metodos terapeuticos y composiciones que implican estructuras de tipo isoflav-3-eno e isoflavano.
US9173866B2 (en) 2002-07-24 2015-11-03 Children's Hospital Medical Center Compositions and products containing R-equol, and methods for their making
AU2002951833A0 (en) * 2002-10-02 2002-10-24 Novogen Research Pty Ltd Compositions and therapeutic methods invloving platinum complexes
AU2002952453A0 (en) * 2002-11-01 2002-11-21 Novogen Research Pty Ltd Aminated isoflavonoid derivatives and uses thereof
AU2004273910A1 (en) * 2003-09-18 2005-03-31 Combinatorx, Incorporated Combinations of drugs for the treatment of neoplasms
US20050154452A1 (en) 2003-12-23 2005-07-14 Medtronic Vascular, Inc. Medical devices to treat or inhibit restenosis
US7434690B2 (en) 2004-04-30 2008-10-14 Cutispharma, Inc. Container and method for the preparation, storage and dispensing of compounded suppositories
US8080675B2 (en) * 2004-09-21 2011-12-20 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
ATE532777T1 (de) * 2004-09-21 2011-11-15 Marshall Edwards Inc Substituierte chromanderivate, medikamente und anwendungen in der therapie
DE102005009515A1 (de) 2005-02-25 2006-09-07 Exner, Heinrich, Dr. Verfahren zur Herstellung einer Zubereitung einer DMSO-haltigen festen Silikonölemulsion zur Bindung von reaktiven Sauerstoffverbindungen im Körper von Menschen und Tieren
US20090131513A1 (en) 2005-03-24 2009-05-21 Novogen Research Pty Ltd. Anti-inflammatory modalities
JP2009508869A (ja) 2005-09-15 2009-03-05 ユーエムディー, インコーポレイテッド シトクロムp450についての基質活性を持つ上皮内及び全体的な曝露の増大のための方法、及び膜流出系それに次ぐ鞘及び口腔の管理
US20070196381A1 (en) 2006-02-17 2007-08-23 Natures Benefit, Inc. Herbal compositions, methods of stimulating immunomodulation and enhancement of immunomodulating agents using the herbal compositions
WO2008052256A1 (en) 2006-10-30 2008-05-08 Novogen Research Pty Ltd Prevention and reversal of chemotherapy-induced peripheral neuropathy
EP2160385A4 (en) * 2007-06-29 2010-10-27 Novogen Res Pty Ltd 2-SUBSTITUTED ISOFLAVONOID COMPOUNDS AND MEDICAMENTS THEREOF AND APPLICATIONS THEREOF
US20120039917A1 (en) 2008-08-29 2012-02-16 Alan James Husband Immunomodulating activities
US8729134B2 (en) 2008-11-14 2014-05-20 Heartlink Limited Aryl di-substituted propenone compounds
KR20110004525A (ko) 2009-07-08 2011-01-14 동의대학교 산학협력단 제니스테인과 trail을 포함하는 간암 치료용 조성물
ES2365960B1 (es) 2010-03-31 2012-06-04 Palobiofarma, S.L Nuevos antagonistas de los receptores de adenosina.
EP2766500A4 (en) * 2011-10-14 2015-10-14 Univ Ohio State METHOD AND MATERIALS IN CONNECTION WITH EGG CANCER
ES2734568T3 (es) * 2013-03-13 2019-12-10 Oncoceutics Inc 7-Bencil-10-(2-metilbencil)-2,6,7,8,9,10-hexahidroimidazo[1,2-a]pirido[4,3-d]pirimidin-5(3H)-ona para su uso en el tratamiento de cáncer
SG11201604490SA (en) * 2014-02-07 2016-07-28 Novogen ltd Functionalised benzopyran compounds and use thereof
SG10202111808WA (en) 2015-08-11 2021-11-29 Novartis Ag 5-bromo-2,6-di-(1h-pyrazol-1-yl)pyrimidin-4-amine for use in the treatment of cancer
CN108884159A (zh) * 2015-11-07 2018-11-23 茂体外尔公司 用于癌症治疗的包含肿瘤抑制基因治疗和免疫检查点阻断的组合物
AU2017247006B2 (en) * 2016-04-06 2022-05-12 Noxopharm Limited Radiotherapy improvements
CA3058503A1 (en) 2016-04-06 2017-10-12 Noxopharm Limited Isoflavonoid composition with improved pharmacokinetics
AU2016401508B2 (en) * 2016-04-06 2020-03-26 Noxopharm Limited Improvements in cancer treatment
EP4035667A1 (en) * 2016-04-22 2022-08-03 Noxopharm Limited Chemotherapy improvements with idronoxil
JP7329860B2 (ja) 2018-06-15 2023-08-21 ボード オブ レジェンツ,ザ ユニバーシティ オブ テキサス システム S-エクオールを用いた乳癌の治療及び予防方法
AU2019285641A1 (en) 2018-06-15 2021-04-08 The Board Of Regents Of The University Of Texas System Methods of treating and preventing melanoma with s-equol
WO2020051644A1 (en) 2018-09-13 2020-03-19 Norbio No. 2 Pty Ltd Treatment of peripheral nervous tissue inflammation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005049008A1 (en) * 2003-11-19 2005-06-02 Novogen Research Pty Ltd Combinational radiotherapy and chemotherapy compositions and methods
WO2006032086A1 (en) * 2004-09-21 2006-03-30 Novogen Research Pty Ltd Chroman derivatives, medicaments and use in therapy
WO2015069562A1 (en) * 2013-11-07 2015-05-14 Humanetics Corporation Genistein cancer treatment regimen maximizing cancer radiation therapy benefits

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
"Phase I Study of Idronoxil Combined With Radiation Treatment in Men With Metastatic Prostate Cancer", ClinicalTrials.gov archive [online], NCT03041285 on 1 February 2017, URL: https://clinicaltrials.gov/archive/NCT03041285/2017_02_01, *
GRUCA et al., "Synthetic Genistein Glycosides Inhibiting EGFR phosphorylation Enhance the Effect of Radiation in HCT 116 Colon Cancer Cells", Molecules, (2014), vol. 19, no. 11, pages 18558 - 18573 *
KIM et al., "Genistein decreases cellular redox potential, partially supresses cell growth in HL-60 leukemia cells and sensitizes cells to γ-irradiation-induced cell death", Molecular Medicine Reports, (2014), vol. 10, no. 6, pp. 2786-2792 *
LUDGATE, "Optimizing Cancer Treatments to Induce an Acute Immune Response: Radiation Abscopal Effects, PAMPS, and DAMPs", Clinical Cancer Research, (2012), vol. 18, no. 17, pages 4522 - 4525 *
RAFFOUL et al., "Radiosensitization of prostate cancer by soy isoflavones", Current Cancer Drug Targets, (2007-12-01), vol. 7, no. 8, doi:10.2174/156800907783220408, ISSN 1568-0096, pages 759 - 765 *
SHIN et al., "Sensitization of the Apoptotic Effect of y-Irradiation in Genistein- pretreated CaSki Cervical Cancer Cells", Journal of Microbiology & Biotechnology, (2008), vol. 18, no. 3, pages 523 - 531 *

Also Published As

Publication number Publication date
US20190262451A1 (en) 2019-08-29
US20220105182A1 (en) 2022-04-07
CA3058492A1 (en) 2017-10-12
AU2017247006A1 (en) 2018-11-01
WO2017173496A1 (en) 2017-10-12
EP3439642A1 (en) 2019-02-13
JP2019513826A (ja) 2019-05-30
US11229703B2 (en) 2022-01-25
EP3439642A4 (en) 2019-11-13

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired