AU2017204682B2 - Compositions and methods for detecting and treating ovarian cancer - Google Patents

Compositions and methods for detecting and treating ovarian cancer Download PDF

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Publication number
AU2017204682B2
AU2017204682B2 AU2017204682A AU2017204682A AU2017204682B2 AU 2017204682 B2 AU2017204682 B2 AU 2017204682B2 AU 2017204682 A AU2017204682 A AU 2017204682A AU 2017204682 A AU2017204682 A AU 2017204682A AU 2017204682 B2 AU2017204682 B2 AU 2017204682B2
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Prior art keywords
cdr
antibodies
progastrin
amino acid
antibody
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AU2017204682A
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AU2017204682A1 (en
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Alexandre PRIEUR
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Progastrine et Cancers SARL
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Progastrine et Cancers SARL
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57545—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the ovaries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/595—Gastrins; Cholecystokinins [CCK]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2017204682A 2015-12-31 2017-01-02 Compositions and methods for detecting and treating ovarian cancer Active AU2017204682B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2021250840A AU2021250840B2 (en) 2015-12-31 2021-10-11 Compositions and methods for detecting and treating ovarian cancer

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP15307192 2015-12-31
EP15307192.3 2015-12-31
EP16305138 2016-02-05
EP16305138.6 2016-02-05
PCT/EP2017/050033 WO2017114972A1 (en) 2015-12-31 2017-01-02 Compositions and methods for detecting and treating ovarian cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021250840A Division AU2021250840B2 (en) 2015-12-31 2021-10-11 Compositions and methods for detecting and treating ovarian cancer

Publications (2)

Publication Number Publication Date
AU2017204682A1 AU2017204682A1 (en) 2018-07-19
AU2017204682B2 true AU2017204682B2 (en) 2021-07-29

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AU2017204682A Active AU2017204682B2 (en) 2015-12-31 2017-01-02 Compositions and methods for detecting and treating ovarian cancer
AU2021250840A Active AU2021250840B2 (en) 2015-12-31 2021-10-11 Compositions and methods for detecting and treating ovarian cancer

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Country Status (13)

Country Link
US (1) US11760808B2 (OSRAM)
EP (2) EP3954999B9 (OSRAM)
JP (2) JP6962920B2 (OSRAM)
KR (2) KR102507685B1 (OSRAM)
CN (1) CN108780091A (OSRAM)
AU (2) AU2017204682B2 (OSRAM)
BR (1) BR112018013271A2 (OSRAM)
CA (2) CA3009751A1 (OSRAM)
EA (1) EA037015B1 (OSRAM)
ES (2) ES2901602T3 (OSRAM)
PL (1) PL3397964T3 (OSRAM)
SG (1) SG11201805605TA (OSRAM)
WO (1) WO2017114972A1 (OSRAM)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240018264A1 (en) * 2015-12-31 2024-01-18 Progastrine Et Cancers S.À R.L. Compositions and methods for detecting and treating ovarian cancer
ES2920283T3 (es) * 2017-12-05 2022-08-02 Progastrine Et Cancers S A R L Terapia de combinación entre un anticuerpo antiprogastrina y la inmunoterapia para tratar el cáncer
JP7338128B2 (ja) 2017-12-08 2023-09-05 イー、シー、エス、ビオトラッカー、エス、エー、アール、エル 癌診断における放射性標識プロガストリン
TW201940881A (zh) 2018-01-26 2019-10-16 瑞士商Ｅｃｓ前胃泌激素公司 在癌症診斷中結合前胃泌激素檢測與其他癌症生物標記的技術
EP3759492A1 (en) 2018-02-27 2021-01-06 ECS-Progastrin SA Progastrin as a biomarker for immunotherapy
JP7687224B2 (ja) * 2022-01-25 2025-06-03 株式会社三洋物産 遊技機
JP7687223B2 (ja) * 2022-01-25 2025-06-03 株式会社三洋物産 遊技機

Citations (2)

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WO2008076454A1 (en) * 2006-12-19 2008-06-26 The Board Of Regents Of The University Of Texas System Immunogenic compositions comprising progastrin and uses thereof
WO2011083091A2 (en) * 2010-01-08 2011-07-14 Bioréalités S.A.S. Methods for treating pancreatic cancer

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Also Published As

Publication number Publication date
EP3954999A1 (en) 2022-02-16
AU2021250840B2 (en) 2024-06-27
JP7279761B2 (ja) 2023-05-23
EA037015B1 (ru) 2021-01-27
KR102428254B1 (ko) 2022-08-03
JP2019502923A (ja) 2019-01-31
KR20220100100A (ko) 2022-07-14
ES2901602T3 (es) 2022-03-23
EP3954999C0 (en) 2025-01-15
BR112018013271A2 (pt) 2018-12-11
EP3397964B1 (en) 2021-09-29
KR102507685B1 (ko) 2023-03-08
PL3397964T3 (pl) 2022-02-07
CA3194356A1 (en) 2017-07-06
US11760808B2 (en) 2023-09-19
WO2017114972A1 (en) 2017-07-06
ES3015244T3 (en) 2025-04-30
CN108780091A (zh) 2018-11-09
EP3954999B1 (en) 2025-01-15
CA3194356C (en) 2025-04-08
CA3009751A1 (en) 2017-07-06
EP3397964A1 (en) 2018-11-07
EA201891529A1 (ru) 2019-01-31
KR20180105647A (ko) 2018-09-28
SG11201805605TA (en) 2018-07-30
AU2021250840A1 (en) 2021-11-04
AU2017204682A1 (en) 2018-07-19
JP6962920B2 (ja) 2021-11-05
US20190002582A1 (en) 2019-01-03
JP2022009080A (ja) 2022-01-14
EP3954999B9 (en) 2025-03-12

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