AU2016377658B2 - Tripartite modulators of endosomal G protein-coupled receptors - Google Patents

Tripartite modulators of endosomal G protein-coupled receptors Download PDF

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Publication number
AU2016377658B2
AU2016377658B2 AU2016377658A AU2016377658A AU2016377658B2 AU 2016377658 B2 AU2016377658 B2 AU 2016377658B2 AU 2016377658 A AU2016377658 A AU 2016377658A AU 2016377658 A AU2016377658 A AU 2016377658A AU 2016377658 B2 AU2016377658 B2 AU 2016377658B2
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Prior art keywords
pain
group
endosomal
optionally
compound
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AU2016377658A
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AU2016377658A1 (en
Inventor
Nigel W. Bunnett
Derek Cole
Gareth HICKS
Gavin Hirst
Christopher J.H. Porter
Junya Shirai
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Endosome Therapeutics Inc
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Endosome Therapeutics Inc
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Priority claimed from AU2015905333A external-priority patent/AU2015905333A0/en
Application filed by Endosome Therapeutics Inc filed Critical Endosome Therapeutics Inc
Publication of AU2016377658A1 publication Critical patent/AU2016377658A1/en
Application granted granted Critical
Publication of AU2016377658B2 publication Critical patent/AU2016377658B2/en
Priority to AU2022291659A priority Critical patent/AU2022291659A1/en
Assigned to ENDOSOME THERAPEUTICS, INC. reassignment ENDOSOME THERAPEUTICS, INC. Request for Assignment Assignors: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Priority to AU2025201136A priority patent/AU2025201136A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
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  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nutrition Science (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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AU2016377658A 2015-12-22 2016-12-21 Tripartite modulators of endosomal G protein-coupled receptors Active AU2016377658B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2022291659A AU2022291659A1 (en) 2015-12-22 2022-12-28 Tripartite modulators of endosomal G protein-coupled receptors
AU2025201136A AU2025201136A1 (en) 2015-12-22 2025-02-18 Tripartite modulators of endosomal G protein-coupled receptors

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AU2015905333A AU2015905333A0 (en) 2015-12-22 Modulators of Endosomal G Protein-Coupled Receptors
AU2015905333 2015-12-22
US201662291161P 2016-02-04 2016-02-04
US62/291,161 2016-02-04
PCT/US2016/068075 WO2017112792A1 (en) 2015-12-22 2016-12-21 Tripartite modulators of endosomal g protein-coupled receptors

Related Child Applications (1)

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AU2022291659A Division AU2022291659A1 (en) 2015-12-22 2022-12-28 Tripartite modulators of endosomal G protein-coupled receptors

Publications (2)

Publication Number Publication Date
AU2016377658A1 AU2016377658A1 (en) 2018-06-21
AU2016377658B2 true AU2016377658B2 (en) 2022-09-29

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AU2016377658A Active AU2016377658B2 (en) 2015-12-22 2016-12-21 Tripartite modulators of endosomal G protein-coupled receptors
AU2022291659A Abandoned AU2022291659A1 (en) 2015-12-22 2022-12-28 Tripartite modulators of endosomal G protein-coupled receptors
AU2025201136A Pending AU2025201136A1 (en) 2015-12-22 2025-02-18 Tripartite modulators of endosomal G protein-coupled receptors

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AU2022291659A Abandoned AU2022291659A1 (en) 2015-12-22 2022-12-28 Tripartite modulators of endosomal G protein-coupled receptors
AU2025201136A Pending AU2025201136A1 (en) 2015-12-22 2025-02-18 Tripartite modulators of endosomal G protein-coupled receptors

Country Status (8)

Country Link
US (3) US11324832B2 (enExample)
EP (1) EP3393519A1 (enExample)
JP (3) JP7074673B2 (enExample)
CN (2) CN115531553A (enExample)
AU (3) AU2016377658B2 (enExample)
CA (1) CA3009325A1 (enExample)
EA (1) EA201891472A1 (enExample)
WO (1) WO2017112792A1 (enExample)

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BR112017018620A2 (pt) 2015-03-04 2018-04-17 Vanda Pharmaceuticals Inc. método de administração de tradipitanto, e, tradipitanto.
CN115531553A (zh) * 2015-12-22 2022-12-30 武田药品工业株式会社 内体g蛋白-偶联的受体的三部分调节剂
EA201892672A1 (ru) * 2016-05-20 2019-04-30 Такеда Фармасьютикал Компани Лимитед Лечение боли
CN119074729A (zh) * 2017-11-17 2024-12-06 万达制药公司 使用川地匹坦治疗胃肠疾病的方法
IT202200018768A1 (it) * 2022-09-14 2024-03-14 Alberto Chiarugi Trattamento della nausea e vomito da chemioterapia
IT202200018780A1 (it) * 2022-09-14 2024-03-14 Alberto Chiarugi Modulatori degli effetti della chemioterapia

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US20030148449A1 (en) * 2000-04-21 2003-08-07 Athan Kuliopulos G protein coupled receptor agonists and antagonists and methods of activating and inhibiting G protein coupled receptors using the same
WO2005097199A1 (en) * 2004-04-08 2005-10-20 Jadolabs Gmbh Tripartite conjugates containing a structure interacting with cell membrane rafts and their use
WO2006004195A1 (en) * 2004-07-02 2006-01-12 Tanabe Seiyaku Co., Ltd. Piperidine compound and process for preparing the same
WO2014168721A2 (en) * 2013-04-12 2014-10-16 Tufts Medical Center Methods and systems for designing and/or characterizing soluble lipidated ligand agents

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PT1035115E (pt) * 1999-02-24 2005-01-31 Hoffmann La Roche Derivados de 4-fenilpiridina e a sua utilizacao como antagonistas do receptor nk-1
TWI287003B (en) 2000-07-24 2007-09-21 Hoffmann La Roche 4-phenyl-pyridine derivatives
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JP2008505092A (ja) 2004-06-30 2008-02-21 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 立体選択的脱水によるα，β−不飽和エステル類および酸類
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WO2005097199A1 (en) * 2004-04-08 2005-10-20 Jadolabs Gmbh Tripartite conjugates containing a structure interacting with cell membrane rafts and their use
WO2006004195A1 (en) * 2004-07-02 2006-01-12 Tanabe Seiyaku Co., Ltd. Piperidine compound and process for preparing the same
WO2014168721A2 (en) * 2013-04-12 2014-10-16 Tufts Medical Center Methods and systems for designing and/or characterizing soluble lipidated ligand agents

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JP2024073581A (ja) 2024-05-29
JP2022113164A (ja) 2022-08-03
CA3009325A1 (en) 2017-06-29
EA201891472A1 (ru) 2018-12-28
AU2025201136A1 (en) 2025-03-06
EP3393519A1 (en) 2018-10-31
JP2019503356A (ja) 2019-02-07
CN108712913A (zh) 2018-10-26
WO2017112792A1 (en) 2017-06-29
AU2016377658A1 (en) 2018-06-21
CN108712913B (zh) 2022-06-24
CN115531553A (zh) 2022-12-30
BR112018012425A2 (pt) 2018-12-18
US11324832B2 (en) 2022-05-10
JP7074673B2 (ja) 2022-05-24
US20190000981A1 (en) 2019-01-03
AU2022291659A1 (en) 2023-02-02
US20230119819A1 (en) 2023-04-20
JP7458681B2 (ja) 2024-04-01
US20250235544A1 (en) 2025-07-24

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