AU2016323777B2 - DNA binding agents with a minor groove binding tail - Google Patents

DNA binding agents with a minor groove binding tail Download PDF

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Publication number
AU2016323777B2
AU2016323777B2 AU2016323777A AU2016323777A AU2016323777B2 AU 2016323777 B2 AU2016323777 B2 AU 2016323777B2 AU 2016323777 A AU2016323777 A AU 2016323777A AU 2016323777 A AU2016323777 A AU 2016323777A AU 2016323777 B2 AU2016323777 B2 AU 2016323777B2
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AU
Australia
Prior art keywords
substituted
alkoxy
methyl
compound
hydrogen
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AU2016323777A
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English (en)
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AU2016323777A1 (en
Inventor
Izabela Fokt
Liwei Guo
Arkadiusz Kazimierski
Timothy Madden
Waldemar Priebe
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University of Texas System
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University of Texas System
University of Texas at Austin
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C13/00—Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
    • C07C13/28—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
    • C07C13/32—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings
    • C07C13/62—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with more than three condensed rings
    • C07C13/66—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with more than three condensed rings the condensed ring system contains only four rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/244—Anthraquinone radicals, e.g. sennosides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
AU2016323777A 2015-09-16 2016-09-16 DNA binding agents with a minor groove binding tail Active AU2016323777B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562219380P 2015-09-16 2015-09-16
US62/219,380 2015-09-16
PCT/US2016/052144 WO2017049091A1 (en) 2015-09-16 2016-09-16 Dna binding agents with a minor groove binding tail

Publications (2)

Publication Number Publication Date
AU2016323777A1 AU2016323777A1 (en) 2018-04-12
AU2016323777B2 true AU2016323777B2 (en) 2021-05-13

Family

ID=58289623

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016323777A Active AU2016323777B2 (en) 2015-09-16 2016-09-16 DNA binding agents with a minor groove binding tail

Country Status (8)

Country Link
US (1) US10358439B2 (enExample)
EP (1) EP3350145B1 (enExample)
JP (1) JP6966428B2 (enExample)
CN (1) CN108368006B (enExample)
AU (1) AU2016323777B2 (enExample)
CA (1) CA2998867A1 (enExample)
PL (1) PL3350145T3 (enExample)
WO (1) WO2017049091A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4433039A4 (en) * 2021-11-17 2025-10-29 Univ Texas WATER-SOLUBLE SALTS OF DNA-BINDING AGENTS

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003072058A2 (en) * 2002-02-27 2003-09-04 The Government Of The United States Of America, Representated By The Secretary, Deparment Of Health And Human Services Dna-binding polyamide drug conjugates

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4196127A (en) * 1978-06-01 1980-04-01 Research Corporation Anthracyclines
US4288608A (en) * 1978-06-01 1981-09-08 Research Corporation Synthesis of anthracyclines
ZA814722B (en) * 1980-07-18 1982-07-28 Hoffmann La Roche Novel anthracycline glycosides
CA1174669A (en) * 1980-07-18 1984-09-18 Michael J. Broadhurst Anthracycline glycosides
EP0971716A1 (en) * 1996-03-22 2000-01-19 Waldemar Priebe Bis-anthracyclines with high activity against doxorubicin resistant tumors
GB9812937D0 (en) * 1998-06-16 1998-08-12 Btg Int Ltd Compounds
WO2000056267A2 (en) 1999-03-19 2000-09-28 Waldemar Priebe Methods and compositions for the manufacture of c-3' and c-4' anthracycline antibiotics
KR101186210B1 (ko) * 2002-12-03 2012-10-08 블랜체트 록펠러 뉴로사이언시즈 인스티튜트 혈뇌장벽을 통과하는 물질 수송용 인공 저밀도 지단백질 운반체
SE0401066D0 (sv) * 2004-04-22 2004-04-22 Stefan Sjoeberg Chemical Derivatives
PL380561A1 (pl) 2006-09-05 2008-03-17 Szeja Wiesław Prochem Szeja Sposób otrzymywania pochodnych antracyklin
JP2012520298A (ja) * 2009-03-12 2012-09-06 ルイトポルド・ファーマシューティカルズ・インコーポレーテッド Ｇａｂａに結合したアントラサイクリン−脂質複合体

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003072058A2 (en) * 2002-02-27 2003-09-04 The Government Of The United States Of America, Representated By The Secretary, Deparment Of Health And Human Services Dna-binding polyamide drug conjugates

Also Published As

Publication number Publication date
CN108368006A (zh) 2018-08-03
US10358439B2 (en) 2019-07-23
PL3350145T3 (pl) 2021-05-04
CN108368006B (zh) 2023-03-07
WO2017049091A1 (en) 2017-03-23
JP2018527372A (ja) 2018-09-20
CA2998867A1 (en) 2017-03-23
US20180251454A1 (en) 2018-09-06
EP3350145A4 (en) 2019-03-27
EP3350145A1 (en) 2018-07-25
JP6966428B2 (ja) 2021-11-17
AU2016323777A1 (en) 2018-04-12
EP3350145B1 (en) 2020-09-16

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