PL3350145T3 - Środki wiążące dna z ogonem wiążącym mniejszą bruzdę - Google Patents

Środki wiążące dna z ogonem wiążącym mniejszą bruzdę

Info

Publication number
PL3350145T3
PL3350145T3 PL16847389T PL16847389T PL3350145T3 PL 3350145 T3 PL3350145 T3 PL 3350145T3 PL 16847389 T PL16847389 T PL 16847389T PL 16847389 T PL16847389 T PL 16847389T PL 3350145 T3 PL3350145 T3 PL 3350145T3
Authority
PL
Poland
Prior art keywords
tail
minor groove
binding
dna binding
binding agents
Prior art date
Application number
PL16847389T
Other languages
English (en)
Inventor
Waldemar Priebe
Liwei Guo
Arkadiusz Kazimierski
Izabela Fokt
Timothy Madden
Original Assignee
Board Of Regents, The University Of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Board Of Regents, The University Of Texas System filed Critical Board Of Regents, The University Of Texas System
Publication of PL3350145T3 publication Critical patent/PL3350145T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C13/00Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
    • C07C13/28Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
    • C07C13/32Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings
    • C07C13/62Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with more than three condensed rings
    • C07C13/66Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with more than three condensed rings the condensed ring system contains only four rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14Nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/24Condensed ring systems having three or more rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/24Condensed ring systems having three or more rings
    • C07H15/244Anthraquinone radicals, e.g. sennosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
PL16847389T 2015-09-16 2016-09-16 Środki wiążące dna z ogonem wiążącym mniejszą bruzdę PL3350145T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562219380P 2015-09-16 2015-09-16
EP16847389.0A EP3350145B1 (en) 2015-09-16 2016-09-16 Dna binding agents with a minor groove binding tail
PCT/US2016/052144 WO2017049091A1 (en) 2015-09-16 2016-09-16 Dna binding agents with a minor groove binding tail

Publications (1)

Publication Number Publication Date
PL3350145T3 true PL3350145T3 (pl) 2021-05-04

Family

ID=58289623

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16847389T PL3350145T3 (pl) 2015-09-16 2016-09-16 Środki wiążące dna z ogonem wiążącym mniejszą bruzdę

Country Status (8)

Country Link
US (1) US10358439B2 (pl)
EP (1) EP3350145B1 (pl)
JP (1) JP6966428B2 (pl)
CN (1) CN108368006B (pl)
AU (1) AU2016323777B2 (pl)
CA (1) CA2998867A1 (pl)
PL (1) PL3350145T3 (pl)
WO (1) WO2017049091A1 (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4433039A1 (en) * 2021-11-17 2024-09-25 Board of Regents, The University of Texas System Water-soluble salts of dna binding agents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4196127A (en) * 1978-06-01 1980-04-01 Research Corporation Anthracyclines
US4288608A (en) 1978-06-01 1981-09-08 Research Corporation Synthesis of anthracyclines
CA1174669A (en) * 1980-07-18 1984-09-18 Michael J. Broadhurst Anthracycline glycosides
GB9812937D0 (en) * 1998-06-16 1998-08-12 Btg Int Ltd Compounds
AU778910B2 (en) 1999-03-19 2004-12-23 Houston Pharmaceuticals, Inc. Methods and compositions for the manufacture of C-3' and C-4' anthracycline antibiotics
US7605125B2 (en) * 2002-02-27 2009-10-20 The United States Of America As Represented By The Department Of Health And Human Services DNA-binding polyamide drug conjugates
PL380561A1 (pl) 2006-09-05 2008-03-17 Szeja Wiesław Prochem Szeja Sposób otrzymywania pochodnych antracyklin

Also Published As

Publication number Publication date
US10358439B2 (en) 2019-07-23
CA2998867A1 (en) 2017-03-23
WO2017049091A1 (en) 2017-03-23
AU2016323777A1 (en) 2018-04-12
EP3350145A4 (en) 2019-03-27
AU2016323777B2 (en) 2021-05-13
CN108368006A (zh) 2018-08-03
JP2018527372A (ja) 2018-09-20
EP3350145B1 (en) 2020-09-16
CN108368006B (zh) 2023-03-07
EP3350145A1 (en) 2018-07-25
US20180251454A1 (en) 2018-09-06
JP6966428B2 (ja) 2021-11-17

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