AU2016290654C1 - Solution phase synthesis and crystallization of beta-turn peptidomimetic cyclic salts - Google Patents

Solution phase synthesis and crystallization of beta-turn peptidomimetic cyclic salts Download PDF

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Publication number
AU2016290654C1
AU2016290654C1 AU2016290654A AU2016290654A AU2016290654C1 AU 2016290654 C1 AU2016290654 C1 AU 2016290654C1 AU 2016290654 A AU2016290654 A AU 2016290654A AU 2016290654 A AU2016290654 A AU 2016290654A AU 2016290654 C1 AU2016290654 C1 AU 2016290654C1
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Australia
Prior art keywords
formula
compound
salt
crystalline form
side chain
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AU2016290654A
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English (en)
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AU2016290654B2 (en
AU2016290654A1 (en
AU2016290654A2 (en
Inventor
Martin Bohlin
Chantal Devin
Sébastien Rocchi
Wei Tian
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Mimetogen Pharmaceuticals Inc
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Mimetogen Pharmaceuticals Inc
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Publication of AU2016290654A1 publication Critical patent/AU2016290654A1/en
Publication of AU2016290654A2 publication Critical patent/AU2016290654A2/en
Publication of AU2016290654B2 publication Critical patent/AU2016290654B2/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/306—Extraction; Separation; Purification by precipitation by crystallization
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2016290654A 2015-07-09 2016-07-08 Solution phase synthesis and crystallization of beta-turn peptidomimetic cyclic salts Active AU2016290654C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562190596P 2015-07-09 2015-07-09
US62/190,596 2015-07-09
PCT/EP2016/066281 WO2017005902A1 (en) 2015-07-09 2016-07-08 Solution phase synthesis and crystallization of beta-turn peptidomimetic cyclic salts

Publications (4)

Publication Number Publication Date
AU2016290654A1 AU2016290654A1 (en) 2018-01-25
AU2016290654A2 AU2016290654A2 (en) 2020-08-06
AU2016290654B2 AU2016290654B2 (en) 2021-07-08
AU2016290654C1 true AU2016290654C1 (en) 2021-11-11

Family

ID=56413639

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016290654A Active AU2016290654C1 (en) 2015-07-09 2016-07-08 Solution phase synthesis and crystallization of beta-turn peptidomimetic cyclic salts

Country Status (8)

Country Link
US (4) US10125165B2 (cg-RX-API-DMAC7.html)
EP (2) EP3319978B1 (cg-RX-API-DMAC7.html)
JP (1) JP6801835B2 (cg-RX-API-DMAC7.html)
KR (1) KR102056257B1 (cg-RX-API-DMAC7.html)
CN (2) CN107849089B (cg-RX-API-DMAC7.html)
AU (1) AU2016290654C1 (cg-RX-API-DMAC7.html)
TW (1) TWI708779B (cg-RX-API-DMAC7.html)
WO (1) WO2017005902A1 (cg-RX-API-DMAC7.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3319978B1 (en) 2015-07-09 2025-02-19 Mimetogen Pharmaceuticals, Inc. Solution phase synthesis and crystallization of beta-turn peptidomimetic cyclic salts
SMT202200173T1 (it) 2016-06-01 2022-05-12 Athira Pharma Inc Composti
EP3802554B1 (en) * 2018-05-31 2023-12-13 Sederma Method for solution-phase peptide synthesis and protecting strategies therefore
US11427612B2 (en) * 2018-08-21 2022-08-30 Wayne State University Epimerization-free N to C solid-phase peptide synthesis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013191926A1 (en) * 2012-06-22 2013-12-27 Mimetogen Pharmaceuticals, Inc. Synthesis of beta-turn peptidomimetic cyclic compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPP254898A0 (en) * 1998-03-24 1998-04-23 University Of Queensland, The Peptide turn mimetics
EP1265605B1 (en) 2000-01-18 2006-09-27 McGILL UNIVERSITY Pharmaceutical compositions comprising beta-turn peptidomimetic cyclic compounds
MXPA04012518A (es) * 2002-06-11 2005-02-17 Lilly Co Eli Profarmacos de aminoacidos excitadores.
EP2271337B1 (en) * 2008-04-04 2014-09-03 Mimetogen Pharmaceuticals Inc. Beta-turn peptidomimetic cyclic compounds for treating dry eye
US8653036B2 (en) * 2009-02-27 2014-02-18 Mimetogen Pharmaceuticals Inc. Methods of treating retinitis pigmentosa
US8906261B2 (en) * 2010-07-29 2014-12-09 Merck Patent Gmbh Liquid crystal medium containing thiophene derivatives
JP5710436B2 (ja) * 2011-09-26 2015-04-30 株式会社東芝 パターン形成方法
JP6516974B2 (ja) * 2013-06-14 2019-05-22 豊田合成株式会社 ゴム組成物及びゴム製品
US9200100B2 (en) * 2013-06-20 2015-12-01 Exxonmobil Chemical Patents Inc. Long-bridged salen catalyst
EP3319978B1 (en) * 2015-07-09 2025-02-19 Mimetogen Pharmaceuticals, Inc. Solution phase synthesis and crystallization of beta-turn peptidomimetic cyclic salts

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013191926A1 (en) * 2012-06-22 2013-12-27 Mimetogen Pharmaceuticals, Inc. Synthesis of beta-turn peptidomimetic cyclic compounds

Also Published As

Publication number Publication date
JP6801835B2 (ja) 2020-12-16
CN107849089A (zh) 2018-03-27
JP2018528928A (ja) 2018-10-04
US20210300966A1 (en) 2021-09-30
CA2991661A1 (en) 2017-01-12
KR20180036982A (ko) 2018-04-10
US20230357318A1 (en) 2023-11-09
EP4549450A2 (en) 2025-05-07
EP4549450A3 (en) 2025-07-02
AU2016290654B2 (en) 2021-07-08
US11078234B2 (en) 2021-08-03
CN114874288A (zh) 2022-08-09
US20170008923A1 (en) 2017-01-12
EP3319978B1 (en) 2025-02-19
US10125165B2 (en) 2018-11-13
US11753441B2 (en) 2023-09-12
AU2016290654A1 (en) 2018-01-25
EP3319978A1 (en) 2018-05-16
HK1255355A1 (en) 2019-08-16
EP3319978C0 (en) 2025-02-19
KR102056257B1 (ko) 2019-12-16
TWI708779B (zh) 2020-11-01
AU2016290654A2 (en) 2020-08-06
TW201716425A (zh) 2017-05-16
US12281179B2 (en) 2025-04-22
CN107849089B (zh) 2022-07-05
WO2017005902A1 (en) 2017-01-12
US20190194251A1 (en) 2019-06-27

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DA3 Amendments made section 104

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DA3 Amendments made section 104

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DA2 Applications for amendment section 104

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DA3 Amendments made section 104

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