AU2016283082B2 - Methods for preparing oltipraz - Google Patents

Methods for preparing oltipraz Download PDF

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Publication number
AU2016283082B2
AU2016283082B2 AU2016283082A AU2016283082A AU2016283082B2 AU 2016283082 B2 AU2016283082 B2 AU 2016283082B2 AU 2016283082 A AU2016283082 A AU 2016283082A AU 2016283082 A AU2016283082 A AU 2016283082A AU 2016283082 B2 AU2016283082 B2 AU 2016283082B2
Authority
AU
Australia
Prior art keywords
reaction
solvent
methyl
added
toluene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2016283082A
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English (en)
Other versions
AU2016283082A1 (en
Inventor
Bomi P. Framroze
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ST IP Holding AG
Original Assignee
ST IP Holding AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ST IP Holding AG filed Critical ST IP Holding AG
Priority claimed from PCT/IN2016/050197 external-priority patent/WO2016207914A2/en
Publication of AU2016283082A1 publication Critical patent/AU2016283082A1/en
Application granted granted Critical
Publication of AU2016283082B2 publication Critical patent/AU2016283082B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A61P33/12—Schistosomicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2016283082A 2015-06-25 2016-06-24 Methods for preparing oltipraz Ceased AU2016283082B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN1891DE2015 2015-06-25
IN1891/DEL/2015 2015-06-25
US14/823,256 2015-08-11
US14/823,256 US20160376259A1 (en) 2015-06-25 2015-08-11 Methods for Preparing Oltipraz
PCT/IN2016/050197 WO2016207914A2 (en) 2015-06-25 2016-06-24 Methods for preparing oltipraz

Publications (2)

Publication Number Publication Date
AU2016283082A1 AU2016283082A1 (en) 2018-01-18
AU2016283082B2 true AU2016283082B2 (en) 2020-11-26

Family

ID=57601888

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016283082A Ceased AU2016283082B2 (en) 2015-06-25 2016-06-24 Methods for preparing oltipraz

Country Status (7)

Country Link
US (5) US20160376259A1 (cg-RX-API-DMAC7.html)
EP (1) EP3313835A4 (cg-RX-API-DMAC7.html)
JP (1) JP6773693B2 (cg-RX-API-DMAC7.html)
KR (1) KR20180022838A (cg-RX-API-DMAC7.html)
AU (1) AU2016283082B2 (cg-RX-API-DMAC7.html)
CA (1) CA2989228A1 (cg-RX-API-DMAC7.html)
MA (1) MA42264A (cg-RX-API-DMAC7.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160376259A1 (en) 2015-06-25 2016-12-29 St Ip Holding Ag Methods for Preparing Oltipraz
KR102658015B1 (ko) * 2016-09-12 2024-05-21 에스티 아이피 홀딩 아게 4-메틸-5-(피라진-2-일)-3h-1,2-디티올-3-티온의 제제, 및 그의 제조 및 사용 방법
AU2017322544B2 (en) * 2016-09-12 2022-06-02 St Ip Holding Ag Formulations of 4-methyl-5-(pyrazin-2-yl)-3H-1.2-dithiole-3-thione, taste-modified formulations, and methods of making and using same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040053989A1 (en) * 1999-07-29 2004-03-18 Patrick Prendergast Dithiolthione compounds for the treatment of neurological disorders and for memory enhancement
US20060106079A1 (en) * 2002-11-26 2006-05-18 Cj Corporation Method for preparing oltipraz

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL171985C (nl) * 1976-02-10 1983-06-16 Rhone Poulenc Ind Werkwijze voor het bereiden van preparaten met werking tegen schistosomiasis, de aldus verkregen gevormde preparaten en werkwijze voor het bereiden van 1,2-dithioolverbindingen.
NZ521710A (en) 2000-04-07 2004-06-25 Sang Geon Kim Prophylactic and therapeutic use of oltipraz as an antifibrotic and anticirrhotic agent in the liver and pharmaceutical composition containing oltipraz
ATE540586T1 (de) * 2000-11-20 2012-01-15 Applied Food Sciences Inc Verfahren zur erhöhung des gehalts an zuträglichen verbindungen nach der verarbeitung in getränken, in denen diese verbindungen natürlich vorkommen
KR100629771B1 (ko) 2004-01-27 2006-09-28 씨제이 주식회사 결정성이 감소되거나 무정형화된 올티프라즈의 제조방법
US20160376259A1 (en) 2015-06-25 2016-12-29 St Ip Holding Ag Methods for Preparing Oltipraz

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040053989A1 (en) * 1999-07-29 2004-03-18 Patrick Prendergast Dithiolthione compounds for the treatment of neurological disorders and for memory enhancement
US20060106079A1 (en) * 2002-11-26 2006-05-18 Cj Corporation Method for preparing oltipraz

Also Published As

Publication number Publication date
US20190084971A1 (en) 2019-03-21
EP3313835A4 (en) 2019-01-09
US20210206752A1 (en) 2021-07-08
CA2989228A1 (en) 2016-12-29
AU2016283082A1 (en) 2018-01-18
KR20180022838A (ko) 2018-03-06
JP6773693B2 (ja) 2020-10-21
US10968207B2 (en) 2021-04-06
JP2018520134A (ja) 2018-07-26
EP3313835A2 (en) 2018-05-02
US20200247791A1 (en) 2020-08-06
US20200172522A1 (en) 2020-06-04
MA42264A (fr) 2018-05-02
US20160376259A1 (en) 2016-12-29

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired