AU2016236297B2 - Isolated peptides and fragments thereof from fibrinogen for use as drugs, particularly in skin inflammatory diseases - Google Patents

Isolated peptides and fragments thereof from fibrinogen for use as drugs, particularly in skin inflammatory diseases Download PDF

Info

Publication number
AU2016236297B2
AU2016236297B2 AU2016236297A AU2016236297A AU2016236297B2 AU 2016236297 B2 AU2016236297 B2 AU 2016236297B2 AU 2016236297 A AU2016236297 A AU 2016236297A AU 2016236297 A AU2016236297 A AU 2016236297A AU 2016236297 B2 AU2016236297 B2 AU 2016236297B2
Authority
AU
Australia
Prior art keywords
fragment
seq
acnes
fibrinogen
ala
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2016236297A
Other languages
English (en)
Other versions
AU2016236297A1 (en
Inventor
Vincent Calvez
Nicolas Dupin
Philippe GRANGE
Joël RAINGEAUD
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Institut Gustave Roussy (IGR)
Assistance Publique Hopitaux de Paris APHP
Institut National de la Sante et de la Recherche Medicale INSERM
Sorbonne Universite
Universite Paris Cite
Universite Paris Saclay
Original Assignee
Centre National de la Recherche Scientifique CNRS
Institut Gustave Roussy (IGR)
Assistance Publique Hopitaux de Paris APHP
Institut National de la Sante et de la Recherche Medicale INSERM
Sorbonne Universite
Universite Paris Cite
Universite Paris Saclay
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Institut Gustave Roussy (IGR), Assistance Publique Hopitaux de Paris APHP, Institut National de la Sante et de la Recherche Medicale INSERM, Sorbonne Universite, Universite Paris Cite, Universite Paris Saclay filed Critical Centre National de la Recherche Scientifique CNRS
Publication of AU2016236297A1 publication Critical patent/AU2016236297A1/en
Application granted granted Critical
Publication of AU2016236297B2 publication Critical patent/AU2016236297B2/en
Assigned to CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS, INSTITUT GUSTAVE-ROUSSY, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), UNIVERSITE PARIS-SUD, Universite De Paris reassignment CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) Request for Assignment Assignors: ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT GUSTAVE-ROUSSY, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE PARIS DESCARTES, UNIVERSITE PARIS-SUD, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
Assigned to CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS, INSTITUT GUSTAVE-ROUSSY, UNIVERSITE PARIS-SUD, Universite De Paris, Sorbonne Université reassignment CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) Request for Assignment Assignors: Universite De Paris, ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT GUSTAVE-ROUSSY, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE PARIS-SUD, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
Assigned to CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS, INSTITUT GUSTAVE-ROUSSY, Universite De Paris, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), Sorbonne Université, UNIVERSITÉ PARIS-SACLAY reassignment CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) Request for Assignment Assignors: Sorbonne Université, Universite De Paris, ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT GUSTAVE-ROUSSY, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE PARIS-SUD
Assigned to CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS, INSTITUT GUSTAVE-ROUSSY, Sorbonne Université, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITÉ PARIS-SACLAY, UNIVERSITÉ PARIS CITÉ reassignment CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) Request to Amend Deed and Register Assignors: UNIVERSITÉ PARIS, Sorbonne Université, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS, INSTITUT GUSTAVE-ROUSSY, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2016236297A 2015-03-20 2016-03-21 Isolated peptides and fragments thereof from fibrinogen for use as drugs, particularly in skin inflammatory diseases Active AU2016236297B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15305414.3 2015-03-20
EP15305414 2015-03-20
PCT/EP2016/056179 WO2016150926A1 (en) 2015-03-20 2016-03-21 Isolated peptides and fragments thereof from fibrinogen for use as drugs, particularly in skin inflammatory diseases

Publications (2)

Publication Number Publication Date
AU2016236297A1 AU2016236297A1 (en) 2017-09-28
AU2016236297B2 true AU2016236297B2 (en) 2020-07-23

Family

ID=52807757

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2016236297A Active AU2016236297B2 (en) 2015-03-20 2016-03-21 Isolated peptides and fragments thereof from fibrinogen for use as drugs, particularly in skin inflammatory diseases

Country Status (10)

Country Link
US (1) US10323078B2 (enExample)
EP (1) EP3270950B1 (enExample)
JP (1) JP6840086B2 (enExample)
CN (1) CN107636011B (enExample)
AU (1) AU2016236297B2 (enExample)
BR (1) BR112017020008A8 (enExample)
CA (1) CA2979812C (enExample)
DK (1) DK3270950T3 (enExample)
ES (1) ES2880795T3 (enExample)
WO (1) WO2016150926A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202500750A (zh) 2023-05-05 2025-01-01 法商賽諾菲公司 用於治療痤瘡的組成物
CN117304303B (zh) * 2023-07-14 2024-07-05 杭州恩和生物科技有限公司 纤连蛋白截短片段、组合物及用途

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990012866A1 (en) * 1989-04-10 1990-11-01 Louisiana State University And Agricultural And Mechanical College Lytic peptides, use for growth, infection and cancer
EP1033401A2 (en) * 1999-02-26 2000-09-06 Genset Expressed sequence tags and encoded human proteins
WO2003003988A2 (en) * 2001-07-06 2003-01-16 Oregon Health & Science University Peptides which modulate blood coagulation and methods of use thereof
CN101618211A (zh) * 2008-07-03 2010-01-06 珠海联邦制药股份有限公司 一种乙肝多肽疫苗及其应用
WO2010054195A2 (en) * 2008-11-07 2010-05-14 Centocor Ortho Biotech Inc. Markers and methods for assessing and treating lupus patients susceptible to photoprovocation

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639940A (en) * 1994-03-03 1997-06-17 Pharmaceutical Proteins Ltd. Production of fibrinogen in transgenic animals
US6783961B1 (en) * 1999-02-26 2004-08-31 Genset S.A. Expressed sequence tags and encoded human proteins
CA2372700A1 (en) * 1999-06-30 2001-01-04 Regents Of The University Of California Diagnostic test for thrombotic or thromboembolic disease
US20040142325A1 (en) * 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
JP2007535654A (ja) * 2003-04-23 2007-12-06 ハンサ メディカル アクチボラゲット 抗連鎖球菌物質の確認方法、及び連鎖球菌感染症治療のためのその使用
AR056138A1 (es) * 2005-10-21 2007-09-19 Hoffmann La Roche Procedimiento para la expresion recombinante de un polipeptido
US20130280820A1 (en) * 2005-12-16 2013-10-24 Schering Corporation Biomarkers for psoriasis
PL2056756T3 (pl) * 2006-08-04 2014-05-30 Stb Ltd Stały opatrunek do leczenia zranionej tkanki
EP2155782A2 (en) * 2007-03-26 2010-02-24 Dako Denmark A/S Mhc peptide complexes and uses thereof in infectious diseases
JP5819725B2 (ja) * 2008-07-09 2015-11-24 プロフィブリックス ビーブイ 組換えフィブリノゲン
WO2011119484A1 (en) * 2010-03-23 2011-09-29 Iogenetics, Llc Bioinformatic processes for determination of peptide binding
AU2012211537B2 (en) * 2011-02-02 2016-12-08 Academisch Ziekenhuis Leiden H.O.D.N. Lumc Anti-carbamylated protein antibodies and the risk for arthritis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990012866A1 (en) * 1989-04-10 1990-11-01 Louisiana State University And Agricultural And Mechanical College Lytic peptides, use for growth, infection and cancer
EP1033401A2 (en) * 1999-02-26 2000-09-06 Genset Expressed sequence tags and encoded human proteins
WO2003003988A2 (en) * 2001-07-06 2003-01-16 Oregon Health & Science University Peptides which modulate blood coagulation and methods of use thereof
CN101618211A (zh) * 2008-07-03 2010-01-06 珠海联邦制药股份有限公司 一种乙肝多肽疫苗及其应用
WO2010054195A2 (en) * 2008-11-07 2010-05-14 Centocor Ortho Biotech Inc. Markers and methods for assessing and treating lupus patients susceptible to photoprovocation

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DGENE ACCESSION NO. AAG00151 & EP 1033401 A2 06 September 2000 *
DGENE ACCESSION NO. AXY65119 & CN 101618211 A 06 January 2010 *
DGENE ACCESSION NO. AYL84711 & WO 2010/054195 A2 14 May 2010 *

Also Published As

Publication number Publication date
WO2016150926A1 (en) 2016-09-29
US10323078B2 (en) 2019-06-18
DK3270950T3 (da) 2021-06-07
US20180105574A1 (en) 2018-04-19
BR112017020008A2 (pt) 2018-06-19
EP3270950B1 (en) 2021-04-21
JP2018512844A (ja) 2018-05-24
EP3270950A1 (en) 2018-01-24
CN107636011A (zh) 2018-01-26
ES2880795T3 (es) 2021-11-25
CN107636011B (zh) 2021-07-02
CA2979812C (en) 2023-08-29
CA2979812A1 (en) 2016-09-29
BR112017020008A8 (pt) 2023-05-02
JP6840086B2 (ja) 2021-03-10
AU2016236297A1 (en) 2017-09-28

Similar Documents

Publication Publication Date Title
Srikrishna et al. Two proteins modulating transendothelial migration of leukocytes recognize novel carboxylated glycans on endothelial cells
Li et al. OM‐LV20, a novel peptide from odorous frog skin, accelerates wound healing in vitro and in vivo
Lande et al. Cationic antimicrobial peptides in psoriatic skin cooperate to break innate tolerance to self‐DNA
Gebrim et al. Antitumor effects of snake venom chemically modified Lys49 phospholipase A2-like BthTX-I and a synthetic peptide derived from its C-terminal region
JP2018515488A (ja) 抗菌療法
Munding et al. The estrogen-responsive B box protein: a novel enhancer of interleukin-1β secretion
Edström Hägerwall et al. β-Microseminoprotein endows post coital seminal plasma with potent candidacidal activity by a calcium-and pH-dependent mechanism
Janssens et al. Natural nitration of CXCL12 reduces its signaling capacity and chemotactic activity in vitro and abrogates intra-articular lymphocyte recruitment in vivo
Jiménez-Charris et al. Divergent functional profiles of acidic and basic phospholipases A2 in the venom of the snake Porthidium lansbergii lansbergii
Grange et al. Characterization of a Propionibacterium acnes surface protein as a fibrinogen-binding protein
Skrzeczynska-Moncznik et al. DNA structures decorated with cathepsin G/secretory leukocyte proteinase inhibitor stimulate IFNI production by plasmacytoid dendritic cells
Kuzmin et al. Comparative in vitro study on cytotoxicity of recombinant β‐hairpin peptides
Sousa‐Filho et al. Biochemical profile, biological activities, and toxic effects of proteins in the Rhinella schneideri parotoid gland secretion
Rotllant et al. Generation, purification and functional characterization of three C3a anaphylatoxins in rainbow trout: role in leukocyte chemotaxis and respiratory burst
Zheng et al. C5a/C5aR1 mediates IMQ‐induced psoriasiform skin inflammation by promoting IL‐17A production from γδ‐T cells
AU2016236297B2 (en) Isolated peptides and fragments thereof from fibrinogen for use as drugs, particularly in skin inflammatory diseases
Rodrigues et al. Proteomic profile, biological activities and antigenic analysis of the venom from Bothriopsis bilineata smaragdina (“loro machaco”), a pitviper snake from Peru
Kim et al. Antimicrobial activity of antimicrobial peptide LPcin-YK3 derived from bovine lactophoricin
Rodrigues et al. Proteomic and toxinological characterization of Peruvian pitviper Bothrops brazili (“jergón shushupe”), venom
Vaughan et al. Isolation and characterization of a c-type lysozyme from the nurse shark
Fu et al. The anti-myotoxic effects and mechanisms of Sinonatrix annularis serum and a novel plasma metalloproteinase inhibitor towards Deinagkistrodon acutus envenomation
Sharma et al. Immunoglobulin isotype isolated from human placental extract does not interfere in complement-mediated bacterial opsonization within the wound milieu
CN118773176B (zh) 一种蛇毒类凝血酶蛋白及其制备方法与应用
Bame et al. Characterization of a novel intracellular heparanase that has a FERM domain
Sänger The response of fibroblasts to hyperosmotic stress: Mechanisms and functions in skin homeostasis and wound healing

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

Free format text: FORMER OWNER(S): CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); INSTITUT GUSTAVE-ROUSSY; ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS; UNIVERSITE PARIS DESCARTES; UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6); UNIVERSITE PARIS-SUD

Owner name: UNIVERSITE PARIS-SUD

Free format text: FORMER OWNER(S): CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); INSTITUT GUSTAVE-ROUSSY; ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS; UNIVERSITE PARIS DESCARTES; UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6); UNIVERSITE PARIS-SUD

Owner name: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)

Free format text: FORMER OWNER(S): CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); INSTITUT GUSTAVE-ROUSSY; ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS; UNIVERSITE PARIS DESCARTES; UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6); UNIVERSITE PARIS-SUD

Owner name: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

Free format text: FORMER OWNER(S): CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); INSTITUT GUSTAVE-ROUSSY; ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS; UNIVERSITE PARIS DESCARTES; UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6); UNIVERSITE PARIS-SUD

Owner name: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

Free format text: FORMER OWNER(S): CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); INSTITUT GUSTAVE-ROUSSY; ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS; UNIVERSITE PARIS DESCARTES; UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6); UNIVERSITE PARIS-SUD

Owner name: INSTITUT GUSTAVE-ROUSSY

Free format text: FORMER OWNER(S): CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); INSTITUT GUSTAVE-ROUSSY; ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS; UNIVERSITE PARIS DESCARTES; UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6); UNIVERSITE PARIS-SUD

Owner name: UNIVERSITE DE PARIS

Free format text: FORMER OWNER(S): CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); INSTITUT GUSTAVE-ROUSSY; ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS; UNIVERSITE PARIS DESCARTES; UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6); UNIVERSITE PARIS-SUD

PC Assignment registered

Owner name: SORBONNE UNIVERSITE

Free format text: FORMER OWNER(S): ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS; UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6); UNIVERSITE PARIS-SUD; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); UNIVERSITE DE PARIS; INSTITUT GUSTAVE-ROUSSY

Owner name: UNIVERSITE DE PARIS

Free format text: FORMER OWNER(S): ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS; UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6); UNIVERSITE PARIS-SUD; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); UNIVERSITE DE PARIS; INSTITUT GUSTAVE-ROUSSY

Owner name: INSTITUT GUSTAVE-ROUSSY

Free format text: FORMER OWNER(S): ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS; UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6); UNIVERSITE PARIS-SUD; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); UNIVERSITE DE PARIS; INSTITUT GUSTAVE-ROUSSY

Owner name: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

Free format text: FORMER OWNER(S): ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS; UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6); UNIVERSITE PARIS-SUD; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); UNIVERSITE DE PARIS; INSTITUT GUSTAVE-ROUSSY

Owner name: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

Free format text: FORMER OWNER(S): ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS; UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6); UNIVERSITE PARIS-SUD; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); UNIVERSITE DE PARIS; INSTITUT GUSTAVE-ROUSSY

Owner name: UNIVERSITE PARIS-SUD

Free format text: FORMER OWNER(S): ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS; UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6); UNIVERSITE PARIS-SUD; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); UNIVERSITE DE PARIS; INSTITUT GUSTAVE-ROUSSY

Owner name: ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

Free format text: FORMER OWNER(S): ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS; UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6); UNIVERSITE PARIS-SUD; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); UNIVERSITE DE PARIS; INSTITUT GUSTAVE-ROUSSY

PC Assignment registered

Owner name: UNIVERSITE PARIS-SACLAY

Free format text: FORMER OWNER(S): UNIVERSITE DE PARIS; INSTITUT GUSTAVE-ROUSSY; SORBONNE UNIVERSITE; UNIVERSITE PARIS-SUD; ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

Owner name: SORBONNE UNIVERSITE

Free format text: FORMER OWNER(S): UNIVERSITE DE PARIS; INSTITUT GUSTAVE-ROUSSY; SORBONNE UNIVERSITE; UNIVERSITE PARIS-SUD; ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

Owner name: UNIVERSITE DE PARIS

Free format text: FORMER OWNER(S): UNIVERSITE DE PARIS; INSTITUT GUSTAVE-ROUSSY; SORBONNE UNIVERSITE; UNIVERSITE PARIS-SUD; ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

Owner name: INSTITUT GUSTAVE-ROUSSY

Free format text: FORMER OWNER(S): UNIVERSITE DE PARIS; INSTITUT GUSTAVE-ROUSSY; SORBONNE UNIVERSITE; UNIVERSITE PARIS-SUD; ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

Owner name: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

Free format text: FORMER OWNER(S): UNIVERSITE DE PARIS; INSTITUT GUSTAVE-ROUSSY; SORBONNE UNIVERSITE; UNIVERSITE PARIS-SUD; ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

Owner name: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

Free format text: FORMER OWNER(S): UNIVERSITE DE PARIS; INSTITUT GUSTAVE-ROUSSY; SORBONNE UNIVERSITE; UNIVERSITE PARIS-SUD; ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

Owner name: ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

Free format text: FORMER OWNER(S): UNIVERSITE DE PARIS; INSTITUT GUSTAVE-ROUSSY; SORBONNE UNIVERSITE; UNIVERSITE PARIS-SUD; ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

HB Alteration of name in register

Owner name: UNIVERSITE PARIS-SACLAY

Free format text: FORMER NAME(S): UNIVERSITE PARIS; ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT GUSTAVE-ROUSSY; SORBONNE UNIVERSITE

Owner name: SORBONNE UNIVERSITE

Free format text: FORMER NAME(S): UNIVERSITE PARIS; ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT GUSTAVE-ROUSSY; SORBONNE UNIVERSITE

Owner name: INSTITUT GUSTAVE-ROUSSY

Free format text: FORMER NAME(S): UNIVERSITE PARIS; ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT GUSTAVE-ROUSSY; SORBONNE UNIVERSITE

Owner name: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

Free format text: FORMER NAME(S): UNIVERSITE PARIS; ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT GUSTAVE-ROUSSY; SORBONNE UNIVERSITE

Owner name: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

Free format text: FORMER NAME(S): UNIVERSITE PARIS; ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT GUSTAVE-ROUSSY; SORBONNE UNIVERSITE

Owner name: ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

Free format text: FORMER NAME(S): UNIVERSITE PARIS; ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT GUSTAVE-ROUSSY; SORBONNE UNIVERSITE

Owner name: UNIVERSITE PARIS CITE

Free format text: FORMER NAME(S): UNIVERSITE PARIS; ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); INSTITUT GUSTAVE-ROUSSY; SORBONNE UNIVERSITE