AU2016219917B2 - Methods, compositions, and kits for treatment of cancer - Google Patents

Methods, compositions, and kits for treatment of cancer Download PDF

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Publication number
AU2016219917B2
AU2016219917B2 AU2016219917A AU2016219917A AU2016219917B2 AU 2016219917 B2 AU2016219917 B2 AU 2016219917B2 AU 2016219917 A AU2016219917 A AU 2016219917A AU 2016219917 A AU2016219917 A AU 2016219917A AU 2016219917 B2 AU2016219917 B2 AU 2016219917B2
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AU
Australia
Prior art keywords
inhibitor
fgfr3
seq
antagonistic
antibody
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Active
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AU2016219917A
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English (en)
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AU2016219917A1 (en
Inventor
Jocelyn Holash
Stephen Lau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fusion Pharmaceuticals Inc
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Fusion Pharmaceuticals Inc
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Filing date
Publication date
Application filed by Fusion Pharmaceuticals Inc filed Critical Fusion Pharmaceuticals Inc
Publication of AU2016219917A1 publication Critical patent/AU2016219917A1/en
Assigned to Rainier Therapeutics, Inc. reassignment Rainier Therapeutics, Inc. Alteration of Name(s) of Applicant(s) under S113 Assignors: BIOCLIN THERAPEUTICS, INC.
Assigned to Fusion Pharmaceuticals Inc. reassignment Fusion Pharmaceuticals Inc. Request for Assignment Assignors: Rainier Therapeutics, Inc.
Application granted granted Critical
Publication of AU2016219917B2 publication Critical patent/AU2016219917B2/en
Priority to AU2022200196A priority Critical patent/AU2022200196B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2016219917A 2015-02-19 2016-02-19 Methods, compositions, and kits for treatment of cancer Active AU2016219917B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2022200196A AU2022200196B2 (en) 2015-02-19 2022-01-13 Methods, compositions, and kits for treatment of cancer

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562118350P 2015-02-19 2015-02-19
US62/118,350 2015-02-19
US201562150235P 2015-04-20 2015-04-20
US62/150,235 2015-04-20
PCT/US2016/018634 WO2016134234A1 (en) 2015-02-19 2016-02-19 Methods, compositions, and kits for treatment of cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2022200196A Division AU2022200196B2 (en) 2015-02-19 2022-01-13 Methods, compositions, and kits for treatment of cancer

Publications (2)

Publication Number Publication Date
AU2016219917A1 AU2016219917A1 (en) 2017-09-07
AU2016219917B2 true AU2016219917B2 (en) 2021-12-16

Family

ID=56689191

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2016219917A Active AU2016219917B2 (en) 2015-02-19 2016-02-19 Methods, compositions, and kits for treatment of cancer
AU2022200196A Expired - Fee Related AU2022200196B2 (en) 2015-02-19 2022-01-13 Methods, compositions, and kits for treatment of cancer

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2022200196A Expired - Fee Related AU2022200196B2 (en) 2015-02-19 2022-01-13 Methods, compositions, and kits for treatment of cancer

Country Status (12)

Country Link
US (1) US20160243228A1 (enExample)
EP (1) EP3258966A4 (enExample)
JP (2) JP6774421B2 (enExample)
KR (1) KR20170137717A (enExample)
CN (1) CN107635583A (enExample)
AU (2) AU2016219917B2 (enExample)
BR (1) BR112017017700A2 (enExample)
CA (1) CA2976638A1 (enExample)
IL (1) IL253979B (enExample)
MX (1) MX2017010595A (enExample)
SG (1) SG11201706727XA (enExample)
WO (1) WO2016134234A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8410250B2 (en) 2009-03-25 2013-04-02 Genentech, Inc. Anti-FGFR3 antibodies and methods using same
GB201007286D0 (en) 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
GB201209613D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
EP3122358B1 (en) 2014-03-26 2020-12-16 Astex Therapeutics Ltd. Combinations of fgfr- and cmet-inhibitors for the treatment of cancer
BR112016022062B1 (pt) 2014-03-26 2023-04-11 Astex Therapeutics Limited Combinação, composição farmacêutica, uso de uma combinação ou de uma composição farmacêutica, e, produto farmacêutico
JO3512B1 (ar) 2014-03-26 2020-07-05 Astex Therapeutics Ltd مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
JOP20200201A1 (ar) 2015-02-10 2017-06-16 Astex Therapeutics Ltd تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين
US10478494B2 (en) * 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
US11155555B2 (en) 2015-09-23 2021-10-26 Janssen Pharmaceutica Nv Compounds
HRP20220012T1 (hr) 2015-09-23 2022-04-01 Janssen Pharmaceutica Nv Bi-heteroaril supstituirani 1,4-benzodiazepini i njihova upotreba za liječenje raka
CN115177619A (zh) 2015-12-17 2022-10-14 卫材R&D管理有限公司 用于乳腺癌的治疗剂
EP3576792A4 (en) * 2017-02-06 2020-09-09 Fusion Pharmaceuticals Inc. METHODS, COMPOSITIONS AND KITS FOR THE TREATMENT OF CANCER
CN108440673B (zh) * 2018-04-08 2021-08-17 海南医学院 Fc融合蛋白PD1/FGFR1及其应用
US20200277387A1 (en) * 2019-03-01 2020-09-03 Rainier Therapeutics, Inc. Methods and compositions for treating cancer
KR20220016803A (ko) * 2019-06-03 2022-02-10 퓨전 파마슈티칼즈 인크. 암을 치료하기 위한 방법 및 조성물
EP4034118A1 (en) * 2019-09-26 2022-08-03 Janssen Pharmaceutica NV Use of fgfr inhibitors in fgfr-genetically altered cancers to enhance patient response to immune checkpoint inhibitors in sequential treatment settings
AR121643A1 (es) * 2020-03-23 2022-06-22 Fusion Pharmaceuticals Inc Radioinmunoconjugados dirigidos a fgfr3 y usos de estos
AR123306A1 (es) 2020-08-21 2022-11-16 Genzyme Corp Anticuerpos fgfr3 y métodos de uso
JPWO2022092085A1 (enExample) * 2020-10-28 2022-05-05
IL322053A (en) 2023-01-13 2025-09-01 Regeneron Pharma FGFR3 binding molecules and methods of using them
WO2025240335A1 (en) 2024-05-13 2025-11-20 Regeneron Pharmaceuticals, Inc. Fgfr3 binding molecules and methods of use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010048026A2 (en) * 2008-10-20 2010-04-29 Imclone Llc Fibroblast growth factor receptor-3 (fgfr-3) inhibitors and methods of treatment

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8410250B2 (en) * 2009-03-25 2013-04-02 Genentech, Inc. Anti-FGFR3 antibodies and methods using same
US8754114B2 (en) * 2010-12-22 2014-06-17 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
AR091649A1 (es) * 2012-07-02 2015-02-18 Bristol Myers Squibb Co Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos
EP2877209A1 (en) * 2012-07-27 2015-06-03 Genentech, Inc. Methods of treating fgfr3 related conditions
WO2015009856A2 (en) * 2013-07-16 2015-01-22 Genentech, Inc. Methods of treating cancer using pd-1 axis binding antagonists and tigit inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010048026A2 (en) * 2008-10-20 2010-04-29 Imclone Llc Fibroblast growth factor receptor-3 (fgfr-3) inhibitors and methods of treatment

Also Published As

Publication number Publication date
JP6774421B2 (ja) 2020-10-21
IL253979A0 (en) 2017-10-31
BR112017017700A2 (pt) 2018-07-31
MX2017010595A (es) 2018-11-12
KR20170137717A (ko) 2017-12-13
WO2016134234A1 (en) 2016-08-25
AU2016219917A1 (en) 2017-09-07
EP3258966A1 (en) 2017-12-27
US20160243228A1 (en) 2016-08-25
CA2976638A1 (en) 2016-08-25
JP2021020909A (ja) 2021-02-18
AU2022200196B2 (en) 2025-04-10
JP7122357B2 (ja) 2022-08-19
SG11201706727XA (en) 2017-09-28
AU2022200196A1 (en) 2022-02-10
JP2018507220A (ja) 2018-03-15
NZ735243A (en) 2024-11-29
CN107635583A (zh) 2018-01-26
EP3258966A4 (en) 2018-07-25
IL253979B (en) 2021-06-30

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Legal Events

Date Code Title Description
HB Alteration of name in register

Owner name: RAINIER THERAPEUTICS, INC.

Free format text: FORMER NAME(S): BIOCLIN THERAPEUTICS, INC.

PC1 Assignment before grant (sect. 113)

Owner name: FUSION PHARMACEUTICALS INC.

Free format text: FORMER APPLICANT(S): RAINIER THERAPEUTICS, INC.

FGA Letters patent sealed or granted (standard patent)