AU2016219917B2 - Methods, compositions, and kits for treatment of cancer - Google Patents

Methods, compositions, and kits for treatment of cancer Download PDF

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Publication number
AU2016219917B2
AU2016219917B2 AU2016219917A AU2016219917A AU2016219917B2 AU 2016219917 B2 AU2016219917 B2 AU 2016219917B2 AU 2016219917 A AU2016219917 A AU 2016219917A AU 2016219917 A AU2016219917 A AU 2016219917A AU 2016219917 B2 AU2016219917 B2 AU 2016219917B2
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AU
Australia
Prior art keywords
inhibitor
fgfr3
seq
antagonistic
antibody
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AU2016219917A
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English (en)
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AU2016219917A1 (en
Inventor
Jocelyn Holash
Stephen Lau
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Fusion Pharmaceuticals Inc
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Fusion Pharmaceuticals Inc
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Publication date
Application filed by Fusion Pharmaceuticals Inc filed Critical Fusion Pharmaceuticals Inc
Publication of AU2016219917A1 publication Critical patent/AU2016219917A1/en
Assigned to Rainier Therapeutics, Inc. reassignment Rainier Therapeutics, Inc. Alteration of Name(s) of Applicant(s) under S113 Assignors: BIOCLIN THERAPEUTICS, INC.
Assigned to Fusion Pharmaceuticals Inc. reassignment Fusion Pharmaceuticals Inc. Request for Assignment Assignors: Rainier Therapeutics, Inc.
Application granted granted Critical
Publication of AU2016219917B2 publication Critical patent/AU2016219917B2/en
Priority to AU2022200196A priority Critical patent/AU2022200196B2/en
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Anticipated expiration legal-status Critical

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2016219917A 2015-02-19 2016-02-19 Methods, compositions, and kits for treatment of cancer Active AU2016219917B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2022200196A AU2022200196B2 (en) 2015-02-19 2022-01-13 Methods, compositions, and kits for treatment of cancer

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562118350P 2015-02-19 2015-02-19
US62/118,350 2015-02-19
US201562150235P 2015-04-20 2015-04-20
US62/150,235 2015-04-20
PCT/US2016/018634 WO2016134234A1 (en) 2015-02-19 2016-02-19 Methods, compositions, and kits for treatment of cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2022200196A Division AU2022200196B2 (en) 2015-02-19 2022-01-13 Methods, compositions, and kits for treatment of cancer

Publications (2)

Publication Number Publication Date
AU2016219917A1 AU2016219917A1 (en) 2017-09-07
AU2016219917B2 true AU2016219917B2 (en) 2021-12-16

Family

ID=56689191

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2016219917A Active AU2016219917B2 (en) 2015-02-19 2016-02-19 Methods, compositions, and kits for treatment of cancer
AU2022200196A Expired - Fee Related AU2022200196B2 (en) 2015-02-19 2022-01-13 Methods, compositions, and kits for treatment of cancer

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2022200196A Expired - Fee Related AU2022200196B2 (en) 2015-02-19 2022-01-13 Methods, compositions, and kits for treatment of cancer

Country Status (12)

Country Link
US (1) US20160243228A1 (enExample)
EP (1) EP3258966A4 (enExample)
JP (2) JP6774421B2 (enExample)
KR (1) KR20170137717A (enExample)
CN (1) CN107635583A (enExample)
AU (2) AU2016219917B2 (enExample)
BR (1) BR112017017700A2 (enExample)
CA (1) CA2976638A1 (enExample)
IL (1) IL253979B (enExample)
MX (1) MX2017010595A (enExample)
SG (1) SG11201706727XA (enExample)
WO (1) WO2016134234A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2549769T3 (es) 2009-03-25 2015-11-02 Genentech, Inc. Anticuerpos anti-FGFR3 y métodos que emplean los mismos
GB201007286D0 (en) 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
GB201209613D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
US10736900B2 (en) 2014-03-26 2020-08-11 Astex Therapeutics Ltd Combinations of an FGFR inhibitor and an IGF1R inhibitor
BR112016022056B1 (pt) 2014-03-26 2023-04-11 Astex Therapeutics Limited Combinação, composição farmacêutica, uso de uma combinação ou uma composição farmacêutica, e, produto farmacêutico
JO3512B1 (ar) 2014-03-26 2020-07-05 Astex Therapeutics Ltd مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
TWI719960B (zh) 2015-02-10 2021-03-01 英商阿斯迪克治療公司 新穎組成物
US10478494B2 (en) * 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
HUE050567T2 (hu) 2015-09-23 2020-12-28 Janssen Pharmaceutica Nv Triciklusos heterociklusok rák kezelésére
WO2017050865A1 (en) 2015-09-23 2017-03-30 Janssen Pharmaceutica Nv Bi-heteroaryl substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer
AU2016374441B2 (en) 2015-12-17 2021-10-21 Eisai R&D Management Co., Ltd. Therapeutic agent for breast cancer
CN110785184A (zh) * 2017-02-06 2020-02-11 雷尼尔医疗公司 用于治疗癌症的方法，组合物和试剂盒
CN108440673B (zh) * 2018-04-08 2021-08-17 海南医学院 Fc融合蛋白PD1/FGFR1及其应用
US20200277387A1 (en) * 2019-03-01 2020-09-03 Rainier Therapeutics, Inc. Methods and compositions for treating cancer
JP2023514795A (ja) * 2019-06-03 2023-04-11 フュージョン ファーマシューティカルズ インコーポレイテッド がんを処置するための方法および組成物
US20220348662A1 (en) * 2019-09-26 2022-11-03 Janssen Pharmaceutica Nv Use of fgfr inhibitors in fgfr-genetically altered cancers to enhance patient response to immune checkpoint inhibitors in sequential treatment settings
KR20220157464A (ko) * 2020-03-23 2022-11-29 퓨전 파마슈티칼즈 인크. Fgfr3-표적화된 방사선면역접합체 및 그의 용도
TW202229343A (zh) 2020-08-21 2022-08-01 美商健臻公司 Fgfr3抗體及使用方法
WO2022092085A1 (ja) * 2020-10-28 2022-05-05 エーザイ・アール・アンド・ディー・マネジメント株式会社 腫瘍治療用医薬組成物
CN121002062A (zh) 2023-01-13 2025-11-21 再生元制药公司 Fgfr3结合分子及其使用方法
WO2025240335A1 (en) 2024-05-13 2025-11-20 Regeneron Pharmaceuticals, Inc. Fgfr3 binding molecules and methods of use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010048026A2 (en) * 2008-10-20 2010-04-29 Imclone Llc Fibroblast growth factor receptor-3 (fgfr-3) inhibitors and methods of treatment

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2549769T3 (es) * 2009-03-25 2015-11-02 Genentech, Inc. Anticuerpos anti-FGFR3 y métodos que emplean los mismos
WO2012088266A2 (en) * 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
AR091649A1 (es) * 2012-07-02 2015-02-18 Bristol Myers Squibb Co Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos
BR112015001724A2 (pt) * 2012-07-27 2018-04-03 Genentech Inc métodos de tratamento de condições relacionadas a fgfr3
TWI888366B (zh) * 2013-07-16 2025-07-01 美商建南德克公司 利用pd-1軸結合拮抗劑及tigit抑制劑治療癌症之方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010048026A2 (en) * 2008-10-20 2010-04-29 Imclone Llc Fibroblast growth factor receptor-3 (fgfr-3) inhibitors and methods of treatment

Also Published As

Publication number Publication date
NZ735243A (en) 2024-11-29
EP3258966A4 (en) 2018-07-25
IL253979A0 (en) 2017-10-31
JP2021020909A (ja) 2021-02-18
JP7122357B2 (ja) 2022-08-19
JP6774421B2 (ja) 2020-10-21
AU2022200196A1 (en) 2022-02-10
CA2976638A1 (en) 2016-08-25
US20160243228A1 (en) 2016-08-25
EP3258966A1 (en) 2017-12-27
CN107635583A (zh) 2018-01-26
SG11201706727XA (en) 2017-09-28
BR112017017700A2 (pt) 2018-07-31
WO2016134234A1 (en) 2016-08-25
AU2016219917A1 (en) 2017-09-07
AU2022200196B2 (en) 2025-04-10
JP2018507220A (ja) 2018-03-15
IL253979B (en) 2021-06-30
KR20170137717A (ko) 2017-12-13
MX2017010595A (es) 2018-11-12

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Legal Events

Date Code Title Description
HB Alteration of name in register

Owner name: RAINIER THERAPEUTICS, INC.

Free format text: FORMER NAME(S): BIOCLIN THERAPEUTICS, INC.

PC1 Assignment before grant (sect. 113)

Owner name: FUSION PHARMACEUTICALS INC.

Free format text: FORMER APPLICANT(S): RAINIER THERAPEUTICS, INC.

FGA Letters patent sealed or granted (standard patent)