AU2015358384B2 - Kinase inhibitor prodrug for the treatment of cancer - Google Patents

Kinase inhibitor prodrug for the treatment of cancer Download PDF

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Publication number
AU2015358384B2
AU2015358384B2 AU2015358384A AU2015358384A AU2015358384B2 AU 2015358384 B2 AU2015358384 B2 AU 2015358384B2 AU 2015358384 A AU2015358384 A AU 2015358384A AU 2015358384 A AU2015358384 A AU 2015358384A AU 2015358384 B2 AU2015358384 B2 AU 2015358384B2
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Australia
Prior art keywords
cancer
egfr
compound
administered
dose
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AU2015358384A
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English (en)
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AU2015358384A1 (en
Inventor
Matthew Roy BULL
Nipun Davar
Christopher Paul Guise
Victoria JACKSON
Adam Vorn Patterson
Tillman PEARCE
Shevan SILVA
Jeffrey Bruce Smaill
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Auckland Uniservices Ltd
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Auckland Uniservices Ltd
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Publication of AU2015358384A1 publication Critical patent/AU2015358384A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2015358384A 2014-12-03 2015-12-03 Kinase inhibitor prodrug for the treatment of cancer Active AU2015358384B2 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201462087212P 2014-12-03 2014-12-03
US62/087,212 2014-12-03
US201562150729P 2015-04-21 2015-04-21
US62/150,729 2015-04-21
US201562167849P 2015-05-28 2015-05-28
US62/167,849 2015-05-28
US201562187750P 2015-07-01 2015-07-01
US62/187,750 2015-07-01
PCT/US2015/063806 WO2016090174A1 (en) 2014-12-03 2015-12-03 Kinase inhibitor prodrug for the treatment of cancer

Publications (2)

Publication Number Publication Date
AU2015358384A1 AU2015358384A1 (en) 2017-06-29
AU2015358384B2 true AU2015358384B2 (en) 2021-03-04

Family

ID=56092487

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015358384A Active AU2015358384B2 (en) 2014-12-03 2015-12-03 Kinase inhibitor prodrug for the treatment of cancer

Country Status (6)

Country Link
US (1) US10507210B2 (enExample)
EP (1) EP3226869A4 (enExample)
JP (1) JP6769962B2 (enExample)
CN (2) CN107427515B (enExample)
AU (1) AU2015358384B2 (enExample)
WO (1) WO2016090174A1 (enExample)

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US10513509B2 (en) 2016-05-26 2019-12-24 Recurium Ip Holdings, Llc EGFR inhibitor compounds
KR102323255B1 (ko) 2017-02-15 2021-11-08 다이호야쿠힌고교 가부시키가이샤 의약 조성물
AU2018329881B2 (en) 2017-09-08 2021-12-02 Taiho Pharmaceutical Co., Ltd. Antitumor agent and antitumor effect potentiator
CA3074017A1 (en) * 2017-09-08 2019-03-14 The Regents Of The University Of Colorado, A Body Corporate Compounds, compositions and methods for treating or preventing her-driven drug-resistant cancers
US20200261414A1 (en) * 2017-09-14 2020-08-20 Lankenau Institute For Medical Research Methods and compositions for the treatment of cancer
WO2019125184A1 (en) * 2017-12-19 2019-06-27 Auckland Uniservices Limited Use of biomarker in cancer therapy
AU2019338185A1 (en) * 2018-09-04 2021-04-22 Rain Therapeutics Inc. Compounds, compositions and methods for treating or preventing her-driven cancers
WO2020084347A2 (en) * 2018-10-26 2020-04-30 Auckland Uniservices Combination of a kinase inhibitor and an immunotherapeutic agent, compositions and methods comprising the same
WO2020102304A1 (en) * 2018-11-13 2020-05-22 Rain Therapeutics Inc. Combination of a kinase inhibitor and an electrolyte, compositions and methods comprising the same
TW202039002A (zh) * 2018-12-07 2020-11-01 斯坦福大學托管董事會 缺氧標靶組成物及其與一parp抑制劑之組合以及此等的使用方法
EP3931224A4 (en) * 2019-02-26 2023-03-01 Janssen Biotech, Inc. COMBINATION TREATMENTS AND PATIENT STRATIFICATION WITH ANTI-EGFR/C-MET BISPECIFIC ANTIBODIES

Citations (1)

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WO2011028135A1 (en) * 2009-09-02 2011-03-10 Auckland Uniservices Limited Kinase inhibitors, prodrug forms thereof and their use in therapy

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Also Published As

Publication number Publication date
EP3226869A1 (en) 2017-10-11
US10507210B2 (en) 2019-12-17
JP2017536408A (ja) 2017-12-07
EP3226869A4 (en) 2018-07-18
AU2015358384A1 (en) 2017-06-29
CN114224894A (zh) 2022-03-25
US20170360790A1 (en) 2017-12-21
CN107427515B (zh) 2021-11-16
WO2016090174A1 (en) 2016-06-09
JP6769962B2 (ja) 2020-10-14
CN114224894B (zh) 2025-01-07
CN107427515A (zh) 2017-12-01

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