AU2015352171A1 - Prevention and treatment of microbial infections - Google Patents
Prevention and treatment of microbial infections Download PDFInfo
- Publication number
- AU2015352171A1 AU2015352171A1 AU2015352171A AU2015352171A AU2015352171A1 AU 2015352171 A1 AU2015352171 A1 AU 2015352171A1 AU 2015352171 A AU2015352171 A AU 2015352171A AU 2015352171 A AU2015352171 A AU 2015352171A AU 2015352171 A1 AU2015352171 A1 AU 2015352171A1
- Authority
- AU
- Australia
- Prior art keywords
- composition
- enzyme
- substrate
- hydrogen peroxide
- convert
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 208000015181 infectious disease Diseases 0.000 title claims abstract description 103
- 238000011282 treatment Methods 0.000 title claims abstract description 74
- 230000000813 microbial effect Effects 0.000 title claims abstract description 70
- 230000002265 prevention Effects 0.000 title claims abstract description 38
- 239000000203 mixture Substances 0.000 claims abstract description 753
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 437
- 102000004190 Enzymes Human genes 0.000 claims abstract description 332
- 108090000790 Enzymes Proteins 0.000 claims abstract description 332
- 239000000758 substrate Substances 0.000 claims abstract description 294
- 230000000694 effects Effects 0.000 claims abstract description 174
- 239000000126 substance Substances 0.000 claims abstract description 171
- 239000005445 natural material Substances 0.000 claims abstract description 72
- 229940088598 enzyme Drugs 0.000 claims description 327
- 235000012907 honey Nutrition 0.000 claims description 243
- 206010052428 Wound Diseases 0.000 claims description 130
- 208000027418 Wounds and injury Diseases 0.000 claims description 130
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 114
- 238000000034 method Methods 0.000 claims description 96
- 230000000845 anti-microbial effect Effects 0.000 claims description 83
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 69
- 239000003125 aqueous solvent Substances 0.000 claims description 66
- 108010015776 Glucose oxidase Proteins 0.000 claims description 64
- 239000004366 Glucose oxidase Substances 0.000 claims description 64
- 229940116332 glucose oxidase Drugs 0.000 claims description 64
- 235000019420 glucose oxidase Nutrition 0.000 claims description 64
- 229920000642 polymer Polymers 0.000 claims description 52
- 102000016938 Catalase Human genes 0.000 claims description 47
- 108010053835 Catalase Proteins 0.000 claims description 47
- 238000010790 dilution Methods 0.000 claims description 47
- 239000012895 dilution Substances 0.000 claims description 47
- 235000000346 sugar Nutrition 0.000 claims description 39
- 208000027157 chronic rhinosinusitis Diseases 0.000 claims description 37
- 241000894006 Bacteria Species 0.000 claims description 32
- 239000003814 drug Substances 0.000 claims description 31
- -1 kit Substances 0.000 claims description 28
- 238000004519 manufacturing process Methods 0.000 claims description 27
- 238000010899 nucleation Methods 0.000 claims description 25
- 241000588626 Acinetobacter baumannii Species 0.000 claims description 24
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims description 24
- 241000191967 Staphylococcus aureus Species 0.000 claims description 24
- 230000001684 chronic effect Effects 0.000 claims description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 23
- 150000003839 salts Chemical class 0.000 claims description 21
- 238000013268 sustained release Methods 0.000 claims description 21
- 239000012730 sustained-release form Substances 0.000 claims description 21
- 230000015572 biosynthetic process Effects 0.000 claims description 20
- 201000003883 Cystic fibrosis Diseases 0.000 claims description 17
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 16
- 230000002401 inhibitory effect Effects 0.000 claims description 16
- 230000012010 growth Effects 0.000 claims description 14
- 238000000338 in vitro Methods 0.000 claims description 14
- 238000001035 drying Methods 0.000 claims description 13
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- 241000894007 species Species 0.000 claims description 12
- 238000005507 spraying Methods 0.000 claims description 12
- 239000008187 granular material Substances 0.000 claims description 11
- 201000009890 sinusitis Diseases 0.000 claims description 11
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims description 10
- 102000004316 Oxidoreductases Human genes 0.000 claims description 10
- 108090000854 Oxidoreductases Proteins 0.000 claims description 10
- 229960003085 meticillin Drugs 0.000 claims description 10
- 206010048038 Wound infection Diseases 0.000 claims description 9
- 239000007787 solid Substances 0.000 claims description 9
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 7
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 7
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 7
- 210000002345 respiratory system Anatomy 0.000 claims description 6
- 201000008827 tuberculosis Diseases 0.000 claims description 6
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 5
- 239000006172 buffering agent Substances 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 238000004108 freeze drying Methods 0.000 claims description 5
- 238000002347 injection Methods 0.000 claims description 5
- 239000007924 injection Substances 0.000 claims description 5
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 5
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 5
- 238000001291 vacuum drying Methods 0.000 claims description 5
- 208000034309 Bacterial disease carrier Diseases 0.000 claims description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 4
- 208000032376 Lung infection Diseases 0.000 claims description 4
- 208000037942 Methicillin-resistant Staphylococcus aureus infection Diseases 0.000 claims description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 4
- 229960001760 dimethyl sulfoxide Drugs 0.000 claims description 4
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 4
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 4
- 239000011780 sodium chloride Substances 0.000 claims description 4
- 238000001694 spray drying Methods 0.000 claims description 4
- 206010072170 Skin wound Diseases 0.000 claims description 3
- 239000007937 lozenge Substances 0.000 claims description 3
- 239000006057 Non-nutritive feed additive Substances 0.000 claims description 2
- 208000032536 Pseudomonas Infections Diseases 0.000 claims description 2
- 239000004067 bulking agent Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 230000032770 biofilm formation Effects 0.000 description 42
- 238000002360 preparation method Methods 0.000 description 41
- 229940105657 catalase Drugs 0.000 description 35
- 210000004027 cell Anatomy 0.000 description 35
- 240000003553 Leptospermum scoparium Species 0.000 description 31
- 235000016887 Leptospermum scoparium Nutrition 0.000 description 31
- 239000000243 solution Substances 0.000 description 31
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 30
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 27
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 26
- 230000001580 bacterial effect Effects 0.000 description 26
- 238000006243 chemical reaction Methods 0.000 description 26
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 24
- 239000000523 sample Substances 0.000 description 24
- 239000004744 fabric Substances 0.000 description 22
- 230000002829 reductive effect Effects 0.000 description 20
- 238000012360 testing method Methods 0.000 description 20
- 239000007921 spray Substances 0.000 description 19
- 230000000844 anti-bacterial effect Effects 0.000 description 18
- 210000001519 tissue Anatomy 0.000 description 18
- WQZGKKKJIJFFOK-SVZMEOIVSA-N (+)-Galactose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-SVZMEOIVSA-N 0.000 description 14
- 239000013078 crystal Substances 0.000 description 14
- 230000000699 topical effect Effects 0.000 description 14
- 239000000306 component Substances 0.000 description 13
- 239000003242 anti bacterial agent Substances 0.000 description 12
- 238000002474 experimental method Methods 0.000 description 12
- 230000008569 process Effects 0.000 description 12
- 239000002195 soluble material Substances 0.000 description 12
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 11
- 201000009267 bronchiectasis Diseases 0.000 description 11
- 239000006071 cream Substances 0.000 description 11
- 239000008103 glucose Substances 0.000 description 11
- 239000007788 liquid Substances 0.000 description 11
- 206010057190 Respiratory tract infections Diseases 0.000 description 10
- 229940088710 antibiotic agent Drugs 0.000 description 10
- 239000004599 antimicrobial Substances 0.000 description 10
- 238000003556 assay Methods 0.000 description 10
- 229940079593 drug Drugs 0.000 description 10
- 210000004072 lung Anatomy 0.000 description 10
- 150000002978 peroxides Chemical class 0.000 description 10
- 241000256844 Apis mellifera Species 0.000 description 9
- 241000589516 Pseudomonas Species 0.000 description 9
- 230000003115 biocidal effect Effects 0.000 description 9
- 239000011248 coating agent Substances 0.000 description 9
- 238000000576 coating method Methods 0.000 description 9
- 239000000499 gel Substances 0.000 description 9
- NOEGNKMFWQHSLB-UHFFFAOYSA-N 5-hydroxymethylfurfural Chemical compound OCC1=CC=C(C=O)O1 NOEGNKMFWQHSLB-UHFFFAOYSA-N 0.000 description 8
- 239000002028 Biomass Substances 0.000 description 8
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 8
- 229940059082 douche Drugs 0.000 description 8
- 230000035876 healing Effects 0.000 description 8
- 239000011159 matrix material Substances 0.000 description 8
- 230000003389 potentiating effect Effects 0.000 description 8
- 230000002459 sustained effect Effects 0.000 description 8
- MINDHVHHQZYEEK-UHFFFAOYSA-N (E)-(2S,3R,4R,5S)-5-[(2S,3S,4S,5S)-2,3-epoxy-5-hydroxy-4-methylhexyl]tetrahydro-3,4-dihydroxy-(beta)-methyl-2H-pyran-2-crotonic acid ester with 9-hydroxynonanoic acid Natural products CC(O)C(C)C1OC1CC1C(O)C(O)C(CC(C)=CC(=O)OCCCCCCCCC(O)=O)OC1 MINDHVHHQZYEEK-UHFFFAOYSA-N 0.000 description 7
- 239000002250 absorbent Substances 0.000 description 7
- 230000002745 absorbent Effects 0.000 description 7
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 7
- 238000011161 development Methods 0.000 description 7
- 230000018109 developmental process Effects 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 150000002402 hexoses Chemical class 0.000 description 7
- DDHVILIIHBIMQU-YJGQQKNPSA-L mupirocin calcium hydrate Chemical compound O.O.[Ca+2].C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@@H]1[C@@H](O)[C@@H](O)[C@H](C\C(C)=C\C(=O)OCCCCCCCCC([O-])=O)OC1.C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@@H]1[C@@H](O)[C@@H](O)[C@H](C\C(C)=C\C(=O)OCCCCCCCCC([O-])=O)OC1 DDHVILIIHBIMQU-YJGQQKNPSA-L 0.000 description 7
- 210000003928 nasal cavity Anatomy 0.000 description 7
- 239000001301 oxygen Substances 0.000 description 7
- 229910052760 oxygen Inorganic materials 0.000 description 7
- 210000003695 paranasal sinus Anatomy 0.000 description 7
- 239000002245 particle Substances 0.000 description 7
- 238000002560 therapeutic procedure Methods 0.000 description 7
- 230000029663 wound healing Effects 0.000 description 7
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 6
- 241000196324 Embryophyta Species 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000000654 additive Substances 0.000 description 6
- 239000000443 aerosol Substances 0.000 description 6
- 239000006161 blood agar Substances 0.000 description 6
- 230000015556 catabolic process Effects 0.000 description 6
- 238000009472 formulation Methods 0.000 description 6
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 6
- 238000003306 harvesting Methods 0.000 description 6
- 239000012535 impurity Substances 0.000 description 6
- 230000002779 inactivation Effects 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- 239000013641 positive control Substances 0.000 description 6
- 230000036515 potency Effects 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 230000009467 reduction Effects 0.000 description 6
- 238000013207 serial dilution Methods 0.000 description 6
- 241000589291 Acinetobacter Species 0.000 description 5
- 241000228245 Aspergillus niger Species 0.000 description 5
- 241000588921 Enterobacteriaceae Species 0.000 description 5
- 241000606768 Haemophilus influenzae Species 0.000 description 5
- 241000257303 Hymenoptera Species 0.000 description 5
- 238000002835 absorbance Methods 0.000 description 5
- 239000000969 carrier Substances 0.000 description 5
- 230000001472 cytotoxic effect Effects 0.000 description 5
- 238000006731 degradation reaction Methods 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 238000000855 fermentation Methods 0.000 description 5
- 230000004151 fermentation Effects 0.000 description 5
- 230000036541 health Effects 0.000 description 5
- 238000007726 management method Methods 0.000 description 5
- 229960003128 mupirocin Drugs 0.000 description 5
- 229930187697 mupirocin Natural products 0.000 description 5
- 239000003921 oil Substances 0.000 description 5
- 238000009928 pasteurization Methods 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- 230000028327 secretion Effects 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 150000008163 sugars Chemical class 0.000 description 5
- 241000588724 Escherichia coli Species 0.000 description 4
- 241000233866 Fungi Species 0.000 description 4
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 4
- 229920002774 Maltodextrin Polymers 0.000 description 4
- 239000005913 Maltodextrin Substances 0.000 description 4
- 241000186359 Mycobacterium Species 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 206010041925 Staphylococcal infections Diseases 0.000 description 4
- 241000191940 Staphylococcus Species 0.000 description 4
- 230000002411 adverse Effects 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 108010051210 beta-Fructofuranosidase Proteins 0.000 description 4
- 210000000621 bronchi Anatomy 0.000 description 4
- 230000001413 cellular effect Effects 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 239000000824 cytostatic agent Substances 0.000 description 4
- 230000001085 cytostatic effect Effects 0.000 description 4
- 239000003085 diluting agent Substances 0.000 description 4
- 230000002538 fungal effect Effects 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 4
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 230000002262 irrigation Effects 0.000 description 4
- 238000003973 irrigation Methods 0.000 description 4
- 229940035034 maltodextrin Drugs 0.000 description 4
- 208000015688 methicillin-resistant staphylococcus aureus infectious disease Diseases 0.000 description 4
- 239000013642 negative control Substances 0.000 description 4
- 230000003647 oxidation Effects 0.000 description 4
- 238000007254 oxidation reaction Methods 0.000 description 4
- 239000006072 paste Substances 0.000 description 4
- 230000037361 pathway Effects 0.000 description 4
- 229920003023 plastic Polymers 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- 230000000069 prophylactic effect Effects 0.000 description 4
- 230000018612 quorum sensing Effects 0.000 description 4
- 208000023504 respiratory system disease Diseases 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- 230000004083 survival effect Effects 0.000 description 4
- 230000009885 systemic effect Effects 0.000 description 4
- 230000001988 toxicity Effects 0.000 description 4
- 231100000419 toxicity Toxicity 0.000 description 4
- 229920001817 Agar Polymers 0.000 description 3
- 241000222122 Candida albicans Species 0.000 description 3
- 208000035473 Communicable disease Diseases 0.000 description 3
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 3
- 206010056340 Diabetic ulcer Diseases 0.000 description 3
- 241000588914 Enterobacter Species 0.000 description 3
- 229930091371 Fructose Natural products 0.000 description 3
- 239000005715 Fructose Substances 0.000 description 3
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 3
- 208000035901 Ischaemic ulcer Diseases 0.000 description 3
- 241000588748 Klebsiella Species 0.000 description 3
- 241000588747 Klebsiella pneumoniae Species 0.000 description 3
- 206010024971 Lower respiratory tract infections Diseases 0.000 description 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 3
- 208000004210 Pressure Ulcer Diseases 0.000 description 3
- 206010036790 Productive cough Diseases 0.000 description 3
- 101100412093 Schizosaccharomyces pombe (strain 972 / ATCC 24843) rec16 gene Proteins 0.000 description 3
- 241000700584 Simplexvirus Species 0.000 description 3
- 229920002125 Sokalan® Polymers 0.000 description 3
- 208000002847 Surgical Wound Diseases 0.000 description 3
- 208000025865 Ulcer Diseases 0.000 description 3
- 206010059442 Wound infection staphylococcal Diseases 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 3
- 239000008272 agar Substances 0.000 description 3
- 230000001476 alcoholic effect Effects 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 230000002421 anti-septic effect Effects 0.000 description 3
- 208000006673 asthma Diseases 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 3
- 239000003139 biocide Substances 0.000 description 3
- 229960001631 carbomer Drugs 0.000 description 3
- 210000003756 cervix mucus Anatomy 0.000 description 3
- 235000019219 chocolate Nutrition 0.000 description 3
- 230000001332 colony forming effect Effects 0.000 description 3
- 231100000433 cytotoxic Toxicity 0.000 description 3
- 238000001804 debridement Methods 0.000 description 3
- 230000007123 defense Effects 0.000 description 3
- 230000006735 deficit Effects 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 231100000673 dose–response relationship Toxicity 0.000 description 3
- 230000008029 eradication Effects 0.000 description 3
- 210000000416 exudates and transudate Anatomy 0.000 description 3
- 239000006260 foam Substances 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- 229940047650 haemophilus influenzae Drugs 0.000 description 3
- 239000000017 hydrogel Substances 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 210000004969 inflammatory cell Anatomy 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 235000011073 invertase Nutrition 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 3
- 229940016286 microcrystalline cellulose Drugs 0.000 description 3
- 239000008108 microcrystalline cellulose Substances 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 231100000252 nontoxic Toxicity 0.000 description 3
- 230000003000 nontoxic effect Effects 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 201000000317 pneumocystosis Diseases 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 235000018102 proteins Nutrition 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 230000002685 pulmonary effect Effects 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- 239000003642 reactive oxygen metabolite Substances 0.000 description 3
- 208000020029 respiratory tract infectious disease Diseases 0.000 description 3
- 239000012488 sample solution Substances 0.000 description 3
- 208000024794 sputum Diseases 0.000 description 3
- 210000003802 sputum Anatomy 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 231100000397 ulcer Toxicity 0.000 description 3
- 206010046901 vaginal discharge Diseases 0.000 description 3
- 230000003612 virological effect Effects 0.000 description 3
- 208000030507 AIDS Diseases 0.000 description 2
- 108010065511 Amylases Proteins 0.000 description 2
- 102000013142 Amylases Human genes 0.000 description 2
- 241000256837 Apidae Species 0.000 description 2
- 201000001178 Bacterial Pneumonia Diseases 0.000 description 2
- 208000004926 Bacterial Vaginosis Diseases 0.000 description 2
- 206010056520 Catheter site infection Diseases 0.000 description 2
- YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 description 2
- 241000223205 Coccidioides immitis Species 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 108010079245 Cystic Fibrosis Transmembrane Conductance Regulator Proteins 0.000 description 2
- 102100023419 Cystic fibrosis transmembrane conductance regulator Human genes 0.000 description 2
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 2
- 239000004375 Dextrin Substances 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 2
- 241000194033 Enterococcus Species 0.000 description 2
- 241000192125 Firmicutes Species 0.000 description 2
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 2
- 208000005230 Leg Ulcer Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241001508003 Mycobacterium abscessus Species 0.000 description 2
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 2
- 108091027881 NEAT1 Proteins 0.000 description 2
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 102000003992 Peroxidases Human genes 0.000 description 2
- 208000037581 Persistent Infection Diseases 0.000 description 2
- 208000005384 Pneumocystis Pneumonia Diseases 0.000 description 2
- 206010073755 Pneumocystis jirovecii pneumonia Diseases 0.000 description 2
- 206010035664 Pneumonia Diseases 0.000 description 2
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 208000037062 Polyps Diseases 0.000 description 2
- 239000004365 Protease Substances 0.000 description 2
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 2
- 208000007313 Reproductive Tract Infections Diseases 0.000 description 2
- 241000725643 Respiratory syncytial virus Species 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 241000277284 Salvelinus fontinalis Species 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 241000193998 Streptococcus pneumoniae Species 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
- 208000037009 Vaginitis bacterial Diseases 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- FBRAWBYQGRLCEK-RJFLZJKCSA-N [(8s,9s,10s,13s,14r,16r,17r)-17-(2-chloroacetyl)-9-fluoro-10,13,16-trimethyl-3,11-dioxo-7,8,12,14,15,16-hexahydro-6h-cyclopenta[a]phenanthren-17-yl] butanoate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@]2(F)[C@@H]1[C@H]1C[C@@H](C)[C@@](C(=O)CCl)(OC(=O)CCC)[C@@]1(C)CC2=O FBRAWBYQGRLCEK-RJFLZJKCSA-N 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000008186 active pharmaceutical agent Substances 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- 102000004139 alpha-Amylases Human genes 0.000 description 2
- 108090000637 alpha-Amylases Proteins 0.000 description 2
- 102000016679 alpha-Glucosidases Human genes 0.000 description 2
- 108010028144 alpha-Glucosidases Proteins 0.000 description 2
- 229940024171 alpha-amylase Drugs 0.000 description 2
- 239000003429 antifungal agent Substances 0.000 description 2
- 229940121375 antifungal agent Drugs 0.000 description 2
- 229940064004 antiseptic throat preparations Drugs 0.000 description 2
- 239000003443 antiviral agent Substances 0.000 description 2
- 229940028420 bactroban Drugs 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 206010006451 bronchitis Diseases 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 229940095731 candida albicans Drugs 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 108010068385 carbapenemase Proteins 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 2
- 229960001231 choline Drugs 0.000 description 2
- 229960002303 citric acid monohydrate Drugs 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- 239000003246 corticosteroid Substances 0.000 description 2
- 229960001334 corticosteroids Drugs 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 235000019425 dextrin Nutrition 0.000 description 2
- 229940111205 diastase Drugs 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 229940008099 dimethicone Drugs 0.000 description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 2
- 231100000676 disease causative agent Toxicity 0.000 description 2
- KHIQYZGEUSTKSB-UHFFFAOYSA-L disodium;4-dodecoxy-4-oxo-3-sulfobutanoate Chemical compound [Na+].[Na+].CCCCCCCCCCCCOC(=O)C(S(O)(=O)=O)CC([O-])=O.CCCCCCCCCCCCOC(=O)C(S(O)(=O)=O)CC([O-])=O KHIQYZGEUSTKSB-UHFFFAOYSA-L 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 238000012377 drug delivery Methods 0.000 description 2
- 229940112141 dry powder inhaler Drugs 0.000 description 2
- 238000001839 endoscopy Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000010408 film Substances 0.000 description 2
- 229940048368 flamazine Drugs 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 239000007897 gelcap Substances 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 235000003869 genetically modified organism Nutrition 0.000 description 2
- 210000004907 gland Anatomy 0.000 description 2
- 239000000174 gluconic acid Substances 0.000 description 2
- 235000012208 gluconic acid Nutrition 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 229920001903 high density polyethylene Polymers 0.000 description 2
- 239000004700 high-density polyethylene Substances 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- 229960001680 ibuprofen Drugs 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 230000002147 killing effect Effects 0.000 description 2
- 239000000865 liniment Substances 0.000 description 2
- 229940040145 liniment Drugs 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 229920001684 low density polyethylene Polymers 0.000 description 2
- 239000004702 low-density polyethylene Substances 0.000 description 2
- 210000002540 macrophage Anatomy 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 229940071648 metered dose inhaler Drugs 0.000 description 2
- 230000009456 molecular mechanism Effects 0.000 description 2
- 210000003097 mucus Anatomy 0.000 description 2
- 239000006199 nebulizer Substances 0.000 description 2
- 210000000440 neutrophil Anatomy 0.000 description 2
- 210000001331 nose Anatomy 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 238000006385 ozonation reaction Methods 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 108040007629 peroxidase activity proteins Proteins 0.000 description 2
- 230000002085 persistent effect Effects 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 150000002989 phenols Chemical class 0.000 description 2
- MEUIIHOXOWVKNP-UHFFFAOYSA-N phosphanylformic acid Chemical compound OC(P)=O MEUIIHOXOWVKNP-UHFFFAOYSA-N 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 239000011505 plaster Substances 0.000 description 2
- 229960000502 poloxamer Drugs 0.000 description 2
- 229920001983 poloxamer Polymers 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
- 150000003214 pyranose derivatives Chemical class 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 230000000241 respiratory effect Effects 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- UEJSSZHHYBHCEL-UHFFFAOYSA-N silver(1+) sulfadiazinate Chemical compound [Ag+].C1=CC(N)=CC=C1S(=O)(=O)[N-]C1=NC=CC=N1 UEJSSZHHYBHCEL-UHFFFAOYSA-N 0.000 description 2
- 238000011301 standard therapy Methods 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 239000006188 syrup Substances 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- 230000000472 traumatic effect Effects 0.000 description 2
- 238000011269 treatment regimen Methods 0.000 description 2
- 241000701161 unidentified adenovirus Species 0.000 description 2
- 230000035899 viability Effects 0.000 description 2
- 230000003253 viricidal effect Effects 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 208000031729 Bacteremia Diseases 0.000 description 1
- 108010077805 Bacterial Proteins Proteins 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 208000010392 Bone Fractures Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 206010006448 Bronchiolitis Diseases 0.000 description 1
- 206010006458 Bronchitis chronic Diseases 0.000 description 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
- 206010007134 Candida infections Diseases 0.000 description 1
- 108091006146 Channels Proteins 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 241001647372 Chlamydia pneumoniae Species 0.000 description 1
- 108010089254 Cholesterol oxidase Proteins 0.000 description 1
- 108010000659 Choline oxidase Proteins 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 208000008960 Diabetic foot Diseases 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 206010013710 Drug interaction Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 239000001692 EU approved anti-caking agent Substances 0.000 description 1
- 206010014561 Emphysema Diseases 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 206010016059 Facial pain Diseases 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 108010015133 Galactose oxidase Proteins 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061598 Immunodeficiency Diseases 0.000 description 1
- 208000029462 Immunodeficiency disease Diseases 0.000 description 1
- 201000008225 Klebsiella pneumonia Diseases 0.000 description 1
- 201000008197 Laryngitis Diseases 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 102000002274 Matrix Metalloproteinases Human genes 0.000 description 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 description 1
- 206010028116 Mucosal inflammation Diseases 0.000 description 1
- 241000186367 Mycobacterium avium Species 0.000 description 1
- 241001502334 Mycobacterium avium complex bacterium Species 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 208000000592 Nasal Polyps Diseases 0.000 description 1
- 206010028748 Nasal obstruction Diseases 0.000 description 1
- 206010028885 Necrotising fasciitis Diseases 0.000 description 1
- 206010029803 Nosocomial infection Diseases 0.000 description 1
- 206010030111 Oedema mucosal Diseases 0.000 description 1
- 102000016387 Pancreatic elastase Human genes 0.000 description 1
- 108010067372 Pancreatic elastase Proteins 0.000 description 1
- 241000894166 Penicillium amagasakiense Species 0.000 description 1
- 208000018262 Peripheral vascular disease Diseases 0.000 description 1
- 241000233870 Pneumocystis Species 0.000 description 1
- 241000142787 Pneumocystis jirovecii Species 0.000 description 1
- 206010035717 Pneumonia klebsiella Diseases 0.000 description 1
- 206010035737 Pneumonia viral Diseases 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920000954 Polyglycolide Polymers 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 108010042687 Pyruvate Oxidase Proteins 0.000 description 1
- 208000004756 Respiratory Insufficiency Diseases 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 206010062255 Soft tissue infection Diseases 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- 241001136559 Talaromyces variabilis Species 0.000 description 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 1
- 208000000558 Varicose Ulcer Diseases 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 238000013272 agar well diffusion method Methods 0.000 description 1
- 208000037883 airway inflammation Diseases 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 238000011203 antimicrobial therapy Methods 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 238000003149 assay kit Methods 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000002457 bidirectional effect Effects 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 230000008238 biochemical pathway Effects 0.000 description 1
- 230000036782 biological activation Effects 0.000 description 1
- 230000008512 biological response Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 201000003984 candidiasis Diseases 0.000 description 1
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 230000008568 cell cell communication Effects 0.000 description 1
- 230000004640 cellular pathway Effects 0.000 description 1
- 230000010094 cellular senescence Effects 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 208000007451 chronic bronchitis Diseases 0.000 description 1
- 208000013116 chronic cough Diseases 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 230000012085 chronic inflammatory response Effects 0.000 description 1
- 201000003486 coccidioidomycosis Diseases 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 208000027744 congestion Diseases 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 229940097362 cyclodextrins Drugs 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 210000004292 cytoskeleton Anatomy 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000008260 defense mechanism Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 238000002716 delivery method Methods 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 102000038379 digestive enzymes Human genes 0.000 description 1
- 108091007734 digestive enzymes Proteins 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 239000006196 drop Substances 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 238000002283 elective surgery Methods 0.000 description 1
- 210000001174 endocardium Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 229920002457 flexible plastic Polymers 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 230000002431 foraging effect Effects 0.000 description 1
- 239000012737 fresh medium Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 229940014259 gelatin Drugs 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 150000002303 glucose derivatives Chemical class 0.000 description 1
- 244000000058 gram-negative pathogen Species 0.000 description 1
- 239000000383 hazardous chemical Substances 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 108010018734 hexose oxidase Proteins 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 239000000416 hydrocolloid Substances 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000007813 immunodeficiency Effects 0.000 description 1
- 230000003308 immunostimulating effect Effects 0.000 description 1
- 230000003116 impacting effect Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007972 injectable composition Substances 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000001573 invertase Substances 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000011866 long-term treatment Methods 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 238000013160 medical therapy Methods 0.000 description 1
- 230000005541 medical transmission Effects 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000011278 mitosis Effects 0.000 description 1
- 235000013379 molasses Nutrition 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 210000002850 nasal mucosa Anatomy 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 239000006225 natural substrate Substances 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 235000021232 nutrient availability Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 238000002638 palliative care Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 235000017807 phytochemicals Nutrition 0.000 description 1
- 229930000223 plant secondary metabolite Natural products 0.000 description 1
- 238000002962 plaque-reduction assay Methods 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 1
- 229920001610 polycaprolactone Polymers 0.000 description 1
- 239000004632 polycaprolactone Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000004633 polyglycolic acid Substances 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 239000011253 protective coating Substances 0.000 description 1
- 108010001816 pyranose oxidase Proteins 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 239000002824 redox indicator Substances 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 201000004193 respiratory failure Diseases 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 206010039083 rhinitis Diseases 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000008786 sensory perception of smell Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 235000021309 simple sugar Nutrition 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 238000003325 tomography Methods 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 229940100615 topical ointment Drugs 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 208000009421 viral pneumonia Diseases 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
- A61K38/443—Oxidoreductases (1) acting on CH-OH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/10—Animals; Substances produced thereby or obtained therefrom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/03—Oxidoreductases acting on the CH-OH group of donors (1.1) with a oxygen as acceptor (1.1.3)
- C12Y101/03004—Glucose oxidase (1.1.3.4)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Insects & Arthropods (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Animal Husbandry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
- Dermatology (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Dentistry (AREA)
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201420856A GB201420856D0 (en) | 2014-11-24 | 2014-11-24 | Prevention and treatment of microbial infections |
| GB1420856.5 | 2014-11-24 | ||
| GB1508313.2 | 2015-05-14 | ||
| GBGB1508313.2A GB201508313D0 (en) | 2015-05-14 | 2015-05-14 | Prevention and treatment of microbial infections |
| GBGB1509654.8A GB201509654D0 (en) | 2015-06-03 | 2015-06-03 | Prevention and treatment of microbial infections |
| GB1509654.8 | 2015-06-03 | ||
| GBGB1511576.9A GB201511576D0 (en) | 2015-07-01 | 2015-07-01 | Prevention and treatment of microbial infections |
| GB1511576.9 | 2015-07-01 | ||
| GB1513047.9 | 2015-07-23 | ||
| GBGB1513047.9A GB201513047D0 (en) | 2015-07-23 | 2015-07-23 | Prevention and treatment of microbial infections |
| GB1518252.0 | 2015-10-15 | ||
| GBGB1518252.0A GB201518252D0 (en) | 2015-10-15 | 2015-10-15 | Prevention and treatment of microbial infections |
| GB1519483.0 | 2015-11-04 | ||
| GBGB1519483.0A GB201519483D0 (en) | 2015-11-04 | 2015-11-04 | Prevention and treatment of microbial infections |
| PCT/GB2015/053584 WO2016083798A1 (fr) | 2014-11-24 | 2015-11-24 | Prévention et traitement d'infections microbiennes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2015352171A1 true AU2015352171A1 (en) | 2017-06-08 |
Family
ID=54782769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015352171A Abandoned AU2015352171A1 (en) | 2014-11-24 | 2015-11-24 | Prevention and treatment of microbial infections |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20170266240A1 (fr) |
| EP (2) | EP3223833B1 (fr) |
| JP (3) | JP2017535571A (fr) |
| CN (1) | CN107847527A (fr) |
| AU (1) | AU2015352171A1 (fr) |
| BR (1) | BR112017010808A2 (fr) |
| CA (1) | CA2968308A1 (fr) |
| ES (1) | ES2750553T3 (fr) |
| GB (2) | GB2547402B (fr) |
| WO (1) | WO2016083798A1 (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2947390C (fr) | 2014-04-30 | 2022-10-18 | Matoke Holdings Limited | Compositions antimicrobiennes |
| CA2975197A1 (fr) * | 2015-02-03 | 2016-08-11 | Matoke Holdings Limited | Compositions et fibres antimicrobiennes |
| WO2017178822A1 (fr) * | 2016-04-12 | 2017-10-19 | Matoke Holdings Limited | Compositions et fibres antimicrobiennes |
| KR102627187B1 (ko) | 2016-05-26 | 2024-01-22 | 킴벌리-클라크 월드와이드, 인크. | 유착 방지 조성물 및 표면에 대한 미생물의 유착을 억제하는 방법 |
| JP2019533661A (ja) * | 2016-10-06 | 2019-11-21 | マトケ・ホールディングス・リミテッド | 抗微生物組成物 |
| WO2018065789A1 (fr) | 2016-10-06 | 2018-04-12 | Matoke Holdings Limited | Compositions antimicrobiennes |
| WO2019077336A1 (fr) * | 2017-10-16 | 2019-04-25 | Matoke Holdings Limited | Double distributeur contenant de l'eau et une composition antimicrobienne |
| GB201716986D0 (en) * | 2017-10-16 | 2017-11-29 | Matoke Holdings Ltd | Antimicrobial compositions |
| GB201805996D0 (en) | 2018-04-11 | 2018-05-23 | Matoke Holdings Ltd | Tissue scaffold |
| US20220175829A1 (en) | 2019-03-27 | 2022-06-09 | Matoke Holdings Limited | Antimicrobial Compositions |
| MX2021014222A (es) * | 2019-05-23 | 2022-02-21 | Arkema Inc | Prevencion de enfermedades en abejas meliferas. |
| WO2021080631A1 (fr) * | 2019-10-24 | 2021-04-29 | Hydrofera, Llc | Pansement contenant une pompe à vide |
| GB2589863A (en) * | 2019-12-09 | 2021-06-16 | Institute Of Tech Sligo | Antimicrobial composition |
| EP4329831A1 (fr) | 2020-03-16 | 2024-03-06 | Matoke Holdings Limited | Compositions antimicrobiennes |
| RU2759744C1 (ru) * | 2020-09-07 | 2021-11-17 | Олег Владимирович Емшанов | Способ борьбы с биологическими плёнками |
| GB202106320D0 (en) | 2021-05-04 | 2021-06-16 | Matoke Holdings Ltd | Antimicrobial dressing |
| EP4122477A1 (fr) * | 2021-07-21 | 2023-01-25 | Mark Edward Fenzl | Miel pour les plaies avec un distributeur à pompe |
| GB202210839D0 (en) | 2022-07-25 | 2022-09-07 | Matoke Holdings Ltd | Antimicrobial compositions |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1987893A (en) | 1931-03-26 | 1935-01-15 | Cornell Universlty | Honey process and product |
| JPS58870A (ja) * | 1981-06-20 | 1983-01-06 | Hayashibara Biochem Lab Inc | 飲食物及びその製造方法 |
| US4617190A (en) * | 1984-08-27 | 1986-10-14 | Laclede Professional Products, Inc. | Enzymatic powder milk |
| DK501686A (da) * | 1986-10-20 | 1988-04-21 | Otto Melchior Poulsen | Enzymholdigt, baktericidt middel samt tandplejemidler og saarbehandlingsmidler, som indeholder det |
| US5310541A (en) * | 1992-08-27 | 1994-05-10 | Montgomery Robert E | Antimicrobial rawhide animal chew containing an oxidoreductase and oxidoreductase substrate |
| BE1017155A3 (nl) * | 2006-06-01 | 2008-03-04 | Sanomedical Bvba | Wondverzorgingsproduct. |
| US20100098645A1 (en) * | 2006-10-06 | 2010-04-22 | Institute Of Technology Sligo | Formulation and method for the treatment of fungal nail infections |
| GB0619786D0 (en) * | 2006-10-06 | 2006-11-15 | Inst Of Technology Sligo | An antimicrobial and immunostimulatory system |
| BE1017344A3 (nl) * | 2006-10-27 | 2008-06-03 | Cnci Bvba | Methode voor het steriliseren van ruwe, onverhitte honing, preparaat voor wondverzorging op basis van honing en een wondverzorging behandelingsproduct. |
| JP2013512897A (ja) * | 2009-12-04 | 2013-04-18 | コルゲート・パーモリブ・カンパニー | 非水性、単一チューブ型の歯磨増白組成物、その使用方法および調製方法 |
| EP2509622B1 (fr) * | 2009-12-09 | 2014-08-20 | KCI Licensing, Inc. | Inhibition des infections bactériennes et de la formation de biofilms |
| WO2012030231A1 (fr) * | 2010-08-30 | 2012-03-08 | Comvita New Zealand Limited | Composition antifongique |
| CA2947390C (fr) * | 2014-04-30 | 2022-10-18 | Matoke Holdings Limited | Compositions antimicrobiennes |
| FR3020948B1 (fr) * | 2014-05-14 | 2018-04-06 | Melipharm | Composition antimicrobienne |
-
2015
- 2015-11-24 CN CN201580073528.4A patent/CN107847527A/zh active Pending
- 2015-11-24 CA CA2968308A patent/CA2968308A1/fr not_active Abandoned
- 2015-11-24 JP JP2017527714A patent/JP2017535571A/ja active Pending
- 2015-11-24 BR BR112017010808A patent/BR112017010808A2/pt not_active Application Discontinuation
- 2015-11-24 EP EP15804915.5A patent/EP3223833B1/fr active Active
- 2015-11-24 EP EP19173943.2A patent/EP3603654A1/fr not_active Withdrawn
- 2015-11-24 GB GB1709530.8A patent/GB2547402B/en active Active
- 2015-11-24 ES ES15804915T patent/ES2750553T3/es active Active
- 2015-11-24 WO PCT/GB2015/053584 patent/WO2016083798A1/fr active Application Filing
- 2015-11-24 US US15/528,969 patent/US20170266240A1/en not_active Abandoned
- 2015-11-24 GB GB1800813.6A patent/GB2554629B8/en active Active
- 2015-11-24 AU AU2015352171A patent/AU2015352171A1/en not_active Abandoned
-
2018
- 2018-11-06 JP JP2018208688A patent/JP2019019141A/ja not_active Withdrawn
-
2020
- 2020-06-17 JP JP2020104329A patent/JP2020158526A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN107847527A (zh) | 2018-03-27 |
| GB201709530D0 (en) | 2017-08-02 |
| JP2017535571A (ja) | 2017-11-30 |
| EP3603654A1 (fr) | 2020-02-05 |
| JP2019019141A (ja) | 2019-02-07 |
| GB201800813D0 (en) | 2018-03-07 |
| JP2020158526A (ja) | 2020-10-01 |
| BR112017010808A2 (pt) | 2017-12-26 |
| GB2554629B (en) | 2018-09-12 |
| GB2554629A (en) | 2018-04-04 |
| GB2547402A (en) | 2017-08-16 |
| ES2750553T3 (es) | 2020-03-26 |
| WO2016083798A8 (fr) | 2016-08-18 |
| CA2968308A1 (fr) | 2016-06-02 |
| US20170266240A1 (en) | 2017-09-21 |
| EP3223833B1 (fr) | 2019-05-15 |
| WO2016083798A1 (fr) | 2016-06-02 |
| GB2547402B (en) | 2018-03-28 |
| GB2554629B8 (en) | 2018-10-03 |
| EP3223833A1 (fr) | 2017-10-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3223833B1 (fr) | Prévention et traitement d'infections microbiennes | |
| AU2016214119B2 (en) | Antimicrobial fibers and compositions | |
| US20220248689A1 (en) | Antimicrobial compositions | |
| US20200323963A1 (en) | Antimicrobial fibers and compositions | |
| JP2018100296A (ja) | 抗菌組成物 | |
| JP2020063234A (ja) | 抗菌組成物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |