AU2015316993B2 - Treatment regimens using anti-NKG2A antibodies - Google Patents

Treatment regimens using anti-NKG2A antibodies Download PDF

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Publication number
AU2015316993B2
AU2015316993B2 AU2015316993A AU2015316993A AU2015316993B2 AU 2015316993 B2 AU2015316993 B2 AU 2015316993B2 AU 2015316993 A AU2015316993 A AU 2015316993A AU 2015316993 A AU2015316993 A AU 2015316993A AU 2015316993 B2 AU2015316993 B2 AU 2015316993B2
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nkg2a
antibody
ser
val
cells
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AU2015316993A1 (en
Inventor
Pascale Andre
Mathieu Blery
Carine Paturel
Caroline SOULAS
Nicolai Wagtmann
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Innate Pharma SA
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Innate Pharma SA
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Priority to AU2021203744A priority Critical patent/AU2021203744B2/en
Priority to AU2025205563A priority patent/AU2025205563A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2015316993A 2014-09-16 2015-09-15 Treatment regimens using anti-NKG2A antibodies Active AU2015316993B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2021203744A AU2021203744B2 (en) 2014-09-16 2021-06-07 Treatment regimens using anti-NKG2A antibodies
AU2025205563A AU2025205563A1 (en) 2014-09-16 2025-07-17 Treatment regimens using anti-NKG2A antibodies

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201462050948P 2014-09-16 2014-09-16
US62/050,948 2014-09-16
US201462067642P 2014-10-23 2014-10-23
US62/067,642 2014-10-23
US201462083929P 2014-11-25 2014-11-25
US62/083,929 2014-11-25
US201462093124P 2014-12-17 2014-12-17
US201462093141P 2014-12-17 2014-12-17
US62/093,124 2014-12-17
US62/093,141 2014-12-17
PCT/EP2015/071073 WO2016041947A1 (en) 2014-09-16 2015-09-15 Treatment regimens using anti-nkg2a antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021203744A Division AU2021203744B2 (en) 2014-09-16 2021-06-07 Treatment regimens using anti-NKG2A antibodies

Publications (2)

Publication Number Publication Date
AU2015316993A1 AU2015316993A1 (en) 2017-03-16
AU2015316993B2 true AU2015316993B2 (en) 2021-03-18

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
AU2015316993A Active AU2015316993B2 (en) 2014-09-16 2015-09-15 Treatment regimens using anti-NKG2A antibodies
AU2021203744A Active AU2021203744B2 (en) 2014-09-16 2021-06-07 Treatment regimens using anti-NKG2A antibodies
AU2025205563A Pending AU2025205563A1 (en) 2014-09-16 2025-07-17 Treatment regimens using anti-NKG2A antibodies

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2021203744A Active AU2021203744B2 (en) 2014-09-16 2021-06-07 Treatment regimens using anti-NKG2A antibodies
AU2025205563A Pending AU2025205563A1 (en) 2014-09-16 2025-07-17 Treatment regimens using anti-NKG2A antibodies

Country Status (14)

Country Link
US (4) US10676523B2 (https=)
EP (1) EP3193929B1 (https=)
JP (4) JP2017538660A (https=)
KR (2) KR20240141862A (https=)
CN (1) CN107074950A (https=)
AU (3) AU2015316993B2 (https=)
CA (1) CA2959463A1 (https=)
DK (1) DK3193929T3 (https=)
ES (1) ES2742456T3 (https=)
HU (1) HUE044704T2 (https=)
IL (1) IL250672B (https=)
PL (1) PL3193929T3 (https=)
SG (2) SG10202007781TA (https=)
WO (1) WO2016041947A1 (https=)

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EP3193929B1 (en) 2019-06-12
EP3193929A1 (en) 2017-07-26
IL250672B (en) 2020-10-29
JP2025016606A (ja) 2025-02-04
US20240368281A1 (en) 2024-11-07
ES2742456T3 (es) 2020-02-14
JP2021008487A (ja) 2021-01-28
US20200299383A1 (en) 2020-09-24
KR20240141862A (ko) 2024-09-27
HUE044704T2 (hu) 2019-11-28
AU2015316993A1 (en) 2017-03-16
DK3193929T3 (da) 2019-08-19
US12037392B2 (en) 2024-07-16
SG10202007781TA (en) 2020-09-29
AU2021203744B2 (en) 2025-04-24
AU2025205563A1 (en) 2025-08-07
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PL3193929T3 (pl) 2019-12-31
CA2959463A1 (en) 2016-03-24
CN107074950A (zh) 2017-08-18
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WO2016041947A1 (en) 2016-03-24
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US10676523B2 (en) 2020-06-09
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US20210238285A1 (en) 2021-08-05
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