AU2015312430B2 - Pharmaceutical compositions comprising levodopa, a dopamine decarboxylase inhibitor and a COMT inhibitor and method of administration thereof - Google Patents

Pharmaceutical compositions comprising levodopa, a dopamine decarboxylase inhibitor and a COMT inhibitor and method of administration thereof Download PDF

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Publication number
AU2015312430B2
AU2015312430B2 AU2015312430A AU2015312430A AU2015312430B2 AU 2015312430 B2 AU2015312430 B2 AU 2015312430B2 AU 2015312430 A AU2015312430 A AU 2015312430A AU 2015312430 A AU2015312430 A AU 2015312430A AU 2015312430 B2 AU2015312430 B2 AU 2015312430B2
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AU
Australia
Prior art keywords
levodopa
carbidopa
dopamine
inhibitor
entacapone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active, expires
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AU2015312430A
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English (en)
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AU2015312430A1 (en
Inventor
Roger Bolsoy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lobsor Pharmaceuticals AB
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Lobsor Pharmaceuticals AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE1451034A external-priority patent/SE538425C2/en
Application filed by Lobsor Pharmaceuticals AB filed Critical Lobsor Pharmaceuticals AB
Publication of AU2015312430A1 publication Critical patent/AU2015312430A1/en
Application granted granted Critical
Publication of AU2015312430B2 publication Critical patent/AU2015312430B2/en
Priority to AU2020239682A priority Critical patent/AU2020239682B2/en
Priority to AU2022200291A priority patent/AU2022200291B2/en
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2015312430A 2014-09-04 2015-09-04 Pharmaceutical compositions comprising levodopa, a dopamine decarboxylase inhibitor and a COMT inhibitor and method of administration thereof Active 2038-09-01 AU2015312430B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2020239682A AU2020239682B2 (en) 2014-09-04 2020-09-23 Pharmaceutical compositions comprising levodopa, a dopamine decarboxylase inhibitor and a COMT inhibitor and method of administration thereof
AU2022200291A AU2022200291B2 (en) 2014-09-04 2022-01-18 Pharmaceutical compositions comprising levodopa, a dopamine decarboxylase inhibitor and a COMT inhibitor and method of administration thereof

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE1451034-1 2014-09-04
SE1451034A SE538425C2 (en) 2014-09-04 2014-09-04 Pharmaceutical compositions comprising levodopa, carbidopa and a comt inhibitor and method of administration thereof
SE1550344-4 2015-03-24
SE1550344 2015-03-24
PCT/SE2015/050939 WO2016036308A1 (en) 2014-09-04 2015-09-04 Pharmaceutical compositions comprising levodopa, a dopamine decarboxylase inhibitor and a comt inhibitor and method of administration thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2020239682A Division AU2020239682B2 (en) 2014-09-04 2020-09-23 Pharmaceutical compositions comprising levodopa, a dopamine decarboxylase inhibitor and a COMT inhibitor and method of administration thereof

Publications (2)

Publication Number Publication Date
AU2015312430A1 AU2015312430A1 (en) 2017-03-30
AU2015312430B2 true AU2015312430B2 (en) 2020-06-25

Family

ID=55440194

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2015312430A Active 2038-09-01 AU2015312430B2 (en) 2014-09-04 2015-09-04 Pharmaceutical compositions comprising levodopa, a dopamine decarboxylase inhibitor and a COMT inhibitor and method of administration thereof
AU2020239682A Active 2038-09-01 AU2020239682B2 (en) 2014-09-04 2020-09-23 Pharmaceutical compositions comprising levodopa, a dopamine decarboxylase inhibitor and a COMT inhibitor and method of administration thereof
AU2022200291A Active 2038-09-01 AU2022200291B2 (en) 2014-09-04 2022-01-18 Pharmaceutical compositions comprising levodopa, a dopamine decarboxylase inhibitor and a COMT inhibitor and method of administration thereof

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2020239682A Active 2038-09-01 AU2020239682B2 (en) 2014-09-04 2020-09-23 Pharmaceutical compositions comprising levodopa, a dopamine decarboxylase inhibitor and a COMT inhibitor and method of administration thereof
AU2022200291A Active 2038-09-01 AU2022200291B2 (en) 2014-09-04 2022-01-18 Pharmaceutical compositions comprising levodopa, a dopamine decarboxylase inhibitor and a COMT inhibitor and method of administration thereof

Country Status (16)

Country Link
US (5) US10071069B2 (cg-RX-API-DMAC7.html)
EP (3) EP4356907A1 (cg-RX-API-DMAC7.html)
JP (2) JP6622310B2 (cg-RX-API-DMAC7.html)
CN (1) CN107072973A (cg-RX-API-DMAC7.html)
AU (3) AU2015312430B2 (cg-RX-API-DMAC7.html)
CA (2) CA2959307C (cg-RX-API-DMAC7.html)
DK (2) DK3782617T3 (cg-RX-API-DMAC7.html)
ES (2) ES2844500T3 (cg-RX-API-DMAC7.html)
FI (1) FI3782617T3 (cg-RX-API-DMAC7.html)
HR (2) HRP20210025T1 (cg-RX-API-DMAC7.html)
HU (2) HUE052857T2 (cg-RX-API-DMAC7.html)
PL (2) PL3782617T3 (cg-RX-API-DMAC7.html)
PT (2) PT3188725T (cg-RX-API-DMAC7.html)
RS (1) RS65337B1 (cg-RX-API-DMAC7.html)
SI (2) SI3188725T1 (cg-RX-API-DMAC7.html)
WO (1) WO2016036308A1 (cg-RX-API-DMAC7.html)

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EP4356907A1 (en) 2014-09-04 2024-04-24 LobSor Pharmaceuticals Aktiebolag Pharmaceutical compositions comprising levodopa, a dopamine decarboxylase inhibitor and a comtinhibitor and method of administration thereof
WO2016083863A1 (en) * 2014-11-28 2016-06-02 Bial - Portela & Ca, S.A. Medicaments for slowing parkinson's disease
CN107847722B (zh) 2015-05-06 2021-05-18 辛纳吉勒公司 包含药物粒子的药用悬浮液、用于其配给的装置、以及其使用方法
WO2017039525A1 (en) 2015-09-04 2017-03-09 Lobsor Pharmaceuticals Aktiebolag Method of treating a dopamine related disorder in a subject by administering levodopa, in combination with a dopamine decarboxylase inhibitor and a catechol-o-methyltransferase inhibitor
US10874629B2 (en) * 2016-04-11 2020-12-29 University Of Canberra Ophthalmic compositions comprising levodopa, an antioxidant and an aqueous carrier
AU2017299710A1 (en) * 2016-07-20 2019-01-31 Abbvie Inc. Levodopa and carbidopa intestinal gel and methods of use
EP3275433A1 (en) 2016-07-29 2018-01-31 Som Innovation Biotech S.L. Sustained release composition comprising micronized tolcapone
JP7257322B2 (ja) 2017-02-13 2023-04-13 バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング プラドフロキサシンを含有する液体組成物
WO2019129120A1 (en) * 2017-12-28 2019-07-04 Rpxds Co., Ltd Tolcapone for prevention and/or treatment of obesity and related metabolic diseases
KR20250043584A (ko) 2018-03-23 2025-03-28 롭서 파마슈티컬스 악티에볼라그 신경퇴행성 장애의 치료를 위한 약제학적 조성물의 연속 투여
EP3593819A1 (en) * 2018-07-10 2020-01-15 Medday Pharmaceuticals Compositions for therapeutic uses containing 5-htp and carbidopa
MX368750B (es) * 2018-08-31 2019-10-15 Cell Therapy And Tech S A De C V Composiciones farmaceuticas semisolidas de base oleosa conteniendo pirfenidona para su aplicacion en la reparacion tisular.
EP4417258A3 (en) * 2018-12-18 2024-10-30 Eli Lilly and Company Dose regimens for use of ly3154207 in the treatment of dopaminergic cns disorders
JP7506371B2 (ja) * 2020-01-20 2024-06-26 国立大学法人浜松医科大学 ドーパミン減少抑制剤
CA3174918A1 (en) * 2020-03-13 2021-09-16 Bial - Portela & Ca, S.A. Micronised opicapone
CN111643493B (zh) * 2020-05-26 2023-01-10 上海京新生物医药有限公司 一种高浓度左旋多巴制剂及其制备方法及其应用
PL4200280T3 (pl) 2020-10-07 2024-05-20 Eli Lilly And Company Pochodne fenylo-3,4-dihydroizochinolin-2(1h)-ylo-etan-1-onu jako dodatnie modulatory allosteryczne receptora dopaminy d1
WO2022158991A1 (en) * 2021-01-20 2022-07-28 Bial-Portela & Ca., S.A. Treatment of pain associated with parkinson's disease with opicapone in combination with levodopa
WO2025162373A1 (en) * 2024-01-30 2025-08-07 National Institute Of Biological Sciences, Beijing Electrophile-containing catechol-o-methyltransferase (comt) inhibitors for targeting the keap1/nrf2 pathway

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Also Published As

Publication number Publication date
US12156858B2 (en) 2024-12-03
CA2959307A1 (en) 2016-03-10
ES2973289T3 (es) 2024-06-19
JP6889231B2 (ja) 2021-06-18
AU2020239682B2 (en) 2021-12-23
FI3782617T3 (fi) 2024-03-13
EP3782617B1 (en) 2024-01-03
US20210023033A1 (en) 2021-01-28
AU2022200291A1 (en) 2022-02-10
DK3782617T3 (da) 2024-03-04
EP4356907A1 (en) 2024-04-24
PL3188725T3 (pl) 2021-08-02
PT3782617T (pt) 2024-02-29
US11413262B2 (en) 2022-08-16
HUE052857T2 (hu) 2021-05-28
EP3188725B1 (en) 2020-10-28
US20220362193A1 (en) 2022-11-17
CA2959307C (en) 2023-03-28
AU2015312430A1 (en) 2017-03-30
CN107072973A (zh) 2017-08-18
US10071069B2 (en) 2018-09-11
US20250041257A1 (en) 2025-02-06
PT3188725T (pt) 2021-01-27
JP6622310B2 (ja) 2019-12-18
US20170231937A1 (en) 2017-08-17
PL3782617T3 (pl) 2024-06-24
DK3188725T3 (da) 2021-01-18
JP2017527623A (ja) 2017-09-21
EP3188725A4 (en) 2018-04-25
ES2844500T3 (es) 2021-07-22
WO2016036308A1 (en) 2016-03-10
US10786472B2 (en) 2020-09-29
AU2020239682A1 (en) 2020-10-15
EP3188725A1 (en) 2017-07-12
HRP20240314T1 (hr) 2024-05-24
EP3782617A1 (en) 2021-02-24
HRP20210025T1 (hr) 2021-03-05
AU2022200291B2 (en) 2024-01-25
RS65337B1 (sr) 2024-04-30
SI3782617T1 (sl) 2024-04-30
HUE066097T2 (hu) 2024-07-28
US20180338944A1 (en) 2018-11-29
SI3188725T1 (sl) 2021-04-30
CA3175785A1 (en) 2016-03-10
JP2020045353A (ja) 2020-03-26

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FGA Letters patent sealed or granted (standard patent)
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Filing date: 20230901

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