AU2015311751B2 - Compositions and methods for treating proliferation disorders - Google Patents

Compositions and methods for treating proliferation disorders Download PDF

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Publication number
AU2015311751B2
AU2015311751B2 AU2015311751A AU2015311751A AU2015311751B2 AU 2015311751 B2 AU2015311751 B2 AU 2015311751B2 AU 2015311751 A AU2015311751 A AU 2015311751A AU 2015311751 A AU2015311751 A AU 2015311751A AU 2015311751 B2 AU2015311751 B2 AU 2015311751B2
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AU
Australia
Prior art keywords
cancer
composition
compound
administered
cell
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Ceased
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AU2015311751A
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English (en)
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AU2015311751A1 (en
Inventor
Daniel T. Dransfield
Sudharshan Eathiraj
Jean-Marc Lapierre
Brian Schwartz
Yi Yu
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Arqule Inc
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Arqule Inc
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Publication of AU2015311751A1 publication Critical patent/AU2015311751A1/en
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Publication of AU2015311751B2 publication Critical patent/AU2015311751B2/en
Priority to AU2020203706A priority Critical patent/AU2020203706B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2015311751A 2014-09-05 2015-09-04 Compositions and methods for treating proliferation disorders Ceased AU2015311751B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2020203706A AU2020203706B2 (en) 2014-09-05 2020-06-04 Compositions and methods for treating proliferation disorders

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462046502P 2014-09-05 2014-09-05
US62/046,502 2014-09-05
US201462082236P 2014-11-20 2014-11-20
US62/082,236 2014-11-20
PCT/US2015/048520 WO2016037044A1 (fr) 2014-09-05 2015-09-04 Compositions et méthodes pour traiter des troubles prolifératifs

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2020203706A Division AU2020203706B2 (en) 2014-09-05 2020-06-04 Compositions and methods for treating proliferation disorders

Publications (2)

Publication Number Publication Date
AU2015311751A1 AU2015311751A1 (en) 2017-03-09
AU2015311751B2 true AU2015311751B2 (en) 2020-03-12

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
AU2015311751A Ceased AU2015311751B2 (en) 2014-09-05 2015-09-04 Compositions and methods for treating proliferation disorders
AU2020203706A Expired - Fee Related AU2020203706B2 (en) 2014-09-05 2020-06-04 Compositions and methods for treating proliferation disorders

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2020203706A Expired - Fee Related AU2020203706B2 (en) 2014-09-05 2020-06-04 Compositions and methods for treating proliferation disorders

Country Status (14)

Country Link
US (1) US9949981B2 (fr)
EP (1) EP3189036B1 (fr)
JP (2) JP6574245B2 (fr)
KR (1) KR20170045748A (fr)
CN (2) CN107074769B (fr)
AU (2) AU2015311751B2 (fr)
BR (1) BR112017004459A2 (fr)
CA (1) CA2958770A1 (fr)
ES (1) ES2955926T3 (fr)
IL (2) IL250715B (fr)
MX (1) MX2017002892A (fr)
RU (2) RU2019142694A (fr)
SG (1) SG11201701704XA (fr)
WO (1) WO2016037044A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201909199PA (en) 2015-08-24 2019-11-28 Epizyme Inc Method for treating cancer
US11561226B2 (en) 2016-03-14 2023-01-24 Pierce Biotechnology Inc. Detection and quantification of AKT-mTOR pathway proteins
WO2018013430A2 (fr) 2016-07-12 2018-01-18 Arisan Therapeutics Inc. Composés hétérocycliques pour le traitement d'une infection à arenavirus
JP7324144B2 (ja) * 2017-02-02 2023-08-09 エピザイム，インコーポレイティド 癌処置様式
WO2019071171A1 (fr) * 2017-10-05 2019-04-11 The Board Of Trustees Of The University Of Illinois Procédé de traitement de la drépanocytose
CN110669015A (zh) * 2018-07-03 2020-01-10 上海喀露蓝科技有限公司 一种fgfr抑制剂的制备方法
CA3119742A1 (fr) * 2018-11-16 2020-05-22 Arqule, Inc. Combinaison pharmaceutique pour le traitement du cancer
US20220184147A1 (en) * 2019-03-04 2022-06-16 Northwestem University Bacterial enzymatic conversion of anthracycline chemotherapeutics to reduce toxicity and promote diversity among the intestinal microbiota
WO2022053708A1 (fr) * 2020-09-14 2022-03-17 Basilea Pharmaceutica International AG Combinaisons pharmaceutiques destinées à être utilisées pour le traitement d'un adénocarcinome gastrique
WO2022068917A1 (fr) * 2020-09-30 2022-04-07 正大天晴药业集团股份有限公司 Composé en tant qu'inhibiteur de la kinase akt
CN112225745B (zh) * 2020-11-16 2021-10-12 烟台大学 一种具有抗肿瘤活性的异片螺素类化合物、制备方法及用途
WO2023168291A1 (fr) * 2022-03-02 2023-09-07 Terremoto Biosciences, Inc. Modificateurs covalents de akt1 et leurs utilisations

Citations (2)

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Publication number Priority date Publication date Assignee Title
US20100239525A1 (en) * 2008-12-30 2010-09-23 Arqule, Inc. Substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds
US20110172203A1 (en) * 2009-12-30 2011-07-14 Arqule, Inc. Substituted Imidazopyridinyl-Aminopyridine Compounds

Family Cites Families (4)

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Publication number Priority date Publication date Assignee Title
TW201036614A (en) * 2008-12-30 2010-10-16 Arqule Inc Substituted 1H-pyrazolo[3,4-d]pyrimidine-6-amine compounds
WO2010114902A1 (fr) * 2009-03-31 2010-10-07 Arqule, Inc. Composés tétrahydropyrazolo-pyrido-azépine substitués
US8815854B2 (en) * 2011-06-24 2014-08-26 Arqule, Inc. Substituted imidazopyridinyl compounds
EP2723741B8 (fr) 2011-06-24 2016-09-21 ArQule, Inc. Composés d'imidazopyridinyle-aminopyridine substitués

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100239525A1 (en) * 2008-12-30 2010-09-23 Arqule, Inc. Substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds
US20110172203A1 (en) * 2009-12-30 2011-07-14 Arqule, Inc. Substituted Imidazopyridinyl-Aminopyridine Compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SALEH, M. et al. "Abstract LB-197: First-in-human study with ARQ 092, a novel pan AKT-inhibitor: Results from the advanced solid tumors cohorts" Cancer Research (2013) Vol.73 No.8 Suppl.1, page LB197 *

Also Published As

Publication number Publication date
RU2711500C2 (ru) 2020-01-17
US9949981B2 (en) 2018-04-24
CN107074769A (zh) 2017-08-18
CN111494378A (zh) 2020-08-07
IL250715B (en) 2020-09-30
EP3189036A4 (fr) 2018-04-04
EP3189036B1 (fr) 2023-07-19
AU2015311751A1 (en) 2017-03-09
EP3189036A1 (fr) 2017-07-12
SG11201701704XA (en) 2017-04-27
JP6574245B2 (ja) 2019-09-11
AU2020203706B2 (en) 2022-01-13
RU2019142694A (ru) 2020-02-26
CN107074769B (zh) 2020-04-07
KR20170045748A (ko) 2017-04-27
ES2955926T3 (es) 2023-12-11
JP6837525B2 (ja) 2021-03-03
CA2958770A1 (fr) 2016-03-10
RU2017111204A3 (fr) 2019-03-25
MX2017002892A (es) 2017-06-06
RU2017111204A (ru) 2018-10-05
IL277028A (en) 2020-10-29
WO2016037044A1 (fr) 2016-03-10
BR112017004459A2 (pt) 2017-12-05
JP2017526698A (ja) 2017-09-14
IL250715A0 (en) 2017-04-30
US20160067260A1 (en) 2016-03-10
JP2020002148A (ja) 2020-01-09
AU2020203706A1 (en) 2020-06-25

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