AU2015305696B2 - High dosage strength tablets of rucaparib - Google Patents

High dosage strength tablets of rucaparib Download PDF

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Publication number
AU2015305696B2
AU2015305696B2 AU2015305696A AU2015305696A AU2015305696B2 AU 2015305696 B2 AU2015305696 B2 AU 2015305696B2 AU 2015305696 A AU2015305696 A AU 2015305696A AU 2015305696 A AU2015305696 A AU 2015305696A AU 2015305696 B2 AU2015305696 B2 AU 2015305696B2
Authority
AU
Australia
Prior art keywords
tablet
rucaparib
tablet according
camsylate
active pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2015305696A
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English (en)
Other versions
AU2015305696A1 (en
Inventor
Jeffrey Etter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharma and Schweiz GmbH
Original Assignee
Pharma and Schweiz GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma and Schweiz GmbH filed Critical Pharma and Schweiz GmbH
Publication of AU2015305696A1 publication Critical patent/AU2015305696A1/en
Application granted granted Critical
Publication of AU2015305696B2 publication Critical patent/AU2015305696B2/en
Priority to AU2019272064A priority Critical patent/AU2019272064B2/en
Assigned to PHARMA& SCHWEIZ GMBH reassignment PHARMA& SCHWEIZ GMBH Request for Assignment Assignors: CLOVIS ONCOLOGY, INC.
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2015305696A 2014-08-22 2015-08-17 High dosage strength tablets of rucaparib Active AU2015305696B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2019272064A AU2019272064B2 (en) 2014-08-22 2019-11-29 High dosage strength tablets of rucaparib

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462040849P 2014-08-22 2014-08-22
US62/040,849 2014-08-22
US201562101739P 2015-01-09 2015-01-09
US62/101,739 2015-01-09
PCT/US2015/045522 WO2016028689A1 (en) 2014-08-22 2015-08-17 High dosage strength tablets of rucaparib

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2019272064A Division AU2019272064B2 (en) 2014-08-22 2019-11-29 High dosage strength tablets of rucaparib

Publications (2)

Publication Number Publication Date
AU2015305696A1 AU2015305696A1 (en) 2017-02-02
AU2015305696B2 true AU2015305696B2 (en) 2019-08-29

Family

ID=55347324

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2015305696A Active AU2015305696B2 (en) 2014-08-22 2015-08-17 High dosage strength tablets of rucaparib
AU2019272064A Active AU2019272064B2 (en) 2014-08-22 2019-11-29 High dosage strength tablets of rucaparib

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2019272064A Active AU2019272064B2 (en) 2014-08-22 2019-11-29 High dosage strength tablets of rucaparib

Country Status (20)

Country Link
US (3) US9987285B2 (cg-RX-API-DMAC7.html)
EP (1) EP3182975B1 (cg-RX-API-DMAC7.html)
JP (3) JP6574477B2 (cg-RX-API-DMAC7.html)
KR (2) KR20170043597A (cg-RX-API-DMAC7.html)
CN (2) CN106794185A (cg-RX-API-DMAC7.html)
AU (2) AU2015305696B2 (cg-RX-API-DMAC7.html)
BR (1) BR112017000865A2 (cg-RX-API-DMAC7.html)
CA (1) CA2955495C (cg-RX-API-DMAC7.html)
DK (1) DK3182975T3 (cg-RX-API-DMAC7.html)
ES (1) ES3048688T3 (cg-RX-API-DMAC7.html)
FI (1) FI3182975T3 (cg-RX-API-DMAC7.html)
IL (1) IL249946B (cg-RX-API-DMAC7.html)
LT (1) LT3182975T (cg-RX-API-DMAC7.html)
MX (1) MX367260B (cg-RX-API-DMAC7.html)
NZ (1) NZ728392A (cg-RX-API-DMAC7.html)
PT (1) PT3182975T (cg-RX-API-DMAC7.html)
RS (1) RS67356B1 (cg-RX-API-DMAC7.html)
RU (1) RU2705156C2 (cg-RX-API-DMAC7.html)
SG (1) SG11201700265VA (cg-RX-API-DMAC7.html)
WO (1) WO2016028689A1 (cg-RX-API-DMAC7.html)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12168004B2 (en) 2014-02-05 2024-12-17 Merck Sharp & Dohme Llc Treatment of migraine
KR20220136460A (ko) 2014-02-05 2022-10-07 머크 샤프 앤드 돔 엘엘씨 Cgrp-활성 화합물에 대한 정제 제제
LT3182975T (lt) * 2014-08-22 2025-11-25 Tabletės su didele rukaparibo doze
CN106008530B (zh) * 2016-07-24 2018-06-26 石家庄久正生物科技有限公司 一种抗卵巢癌药物Rucaparib关键中间体的制备方法
CN108201534A (zh) * 2016-12-16 2018-06-26 苏州苏融生物医药有限公司 一种瑞卡帕布口服缓控释药物组合物及其用途
HRP20241280T1 (hr) 2017-01-24 2024-12-06 Assia Chemical Industries Ltd. Kruti oblici rukapariba i soli rukapariba
MX2019011496A (es) 2017-03-27 2020-01-23 Tesaro Inc Composiciones de niraparib.
EA202090573A1 (ru) * 2017-09-26 2020-09-07 Тесаро, Инк. Составы нирапариба
WO2019130229A1 (en) 2017-12-28 2019-07-04 Mylan Laboratories Ltd Methods and intermediates for preparing rucaparib
PE20211305A1 (es) 2018-01-05 2021-07-20 Cybrexa 1 Inc Compuestos, composiciones y metodos para tratar enfermedades que involucren tejidos con enfermedades acidas o hipoxicas
US12383545B1 (en) 2018-06-08 2025-08-12 Allergan Pharmaceuticals International Limited Treatment of migraine
CN109111454A (zh) * 2018-08-01 2019-01-01 宁波金未生物科技有限公司 一种瑞卡帕布s-樟脑磺酸盐
CN108853030B (zh) * 2018-09-26 2021-10-01 上海朝晖药业有限公司 一种治疗恶性肿瘤的药物制剂及其制备方法
CN111542527A (zh) 2018-12-06 2020-08-14 上海诚妙医药科技有限公司 芦卡帕利樟脑磺酸盐的新晶型和制备方法及其用途
JP7675060B2 (ja) 2019-07-10 2025-05-12 サイブレクサ ３，インコーポレイテッド 治療薬としての微小管標的化剤のペプチドコンジュゲート
CR20220058A (es) 2019-07-10 2022-07-19 Cybrexa 2 Inc Conjugados peptídicos de citotoxinas como terapéuticos
CA3176206A1 (en) 2020-04-28 2021-11-04 Debnath Bhuniya Novel compounds useful as poly(adp-ribose) polymerase (parp) inhibitors
WO2022015557A1 (en) 2020-07-14 2022-01-20 Assia Chemical Industries Ltd Solid state forms of rucaparib salts
AU2021319090A1 (en) 2020-07-29 2023-03-02 Allergan Pharmaceuticals International Limited Treatment of migraine
WO2022090938A1 (en) 2020-10-31 2022-05-05 Rhizen Pharmaceuticals Ag Phthalazinone derivatives useful as parp inhibitors
WO2022140537A1 (en) 2020-12-22 2022-06-30 Allergan Pharmaceuticals International Limited Treatment of migraine
MX2023011793A (es) 2021-04-08 2023-10-12 Rhizen Pharmaceuticals Ag Inhibidores de poli(adenosin difosfato-ribosa) polimerasa.
WO2023049920A1 (en) 2021-09-27 2023-03-30 Allergan Pharmaceuticals International Limited Combination comprising atogepant for treating migraine
EP4429636A1 (en) * 2021-11-10 2024-09-18 Crititech, Inc. Rucaparib particles and uses thereof
EP4463232A1 (en) 2022-01-11 2024-11-20 Assia Chemical Industries Ltd. Solid state forms of rucaparib tosylate

Citations (1)

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US20120302550A1 (en) * 2010-02-12 2012-11-29 Pfizer Inc. Salts and polymorphs of 8-fluoro-2--1,3,4,5-tetrahydro-6h-azepino[5,4,3-cd]indol-6-one

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ES2218110T3 (es) 1999-01-11 2004-11-16 Agouron Pharmaceuticals, Inc. Inhibidores triciclicos de poli(adp-ribosa)polimerasas.
WO2004087713A1 (en) 2003-03-31 2004-10-14 Pfizer Inc. Salts of tricyclic inhibitors of poly(adp-ribose) polymerases
DK1660095T3 (da) 2003-07-25 2010-05-25 Cancer Rec Tech Ltd Tricykliske PARP-inhibitorer
MX2007003314A (es) 2004-09-22 2007-08-06 Pfizer Combinaciones terapeuticas que comprenden inhibidor de poli(adp-ribosa)polimerasas.
ATE551345T1 (de) 2004-09-22 2012-04-15 Pfizer Polymorphe formen des phosphatsalzes von 8-fluor- 2-ä4-ä(methylamino)methylüphenylü-1,3,4,5- tetrahydro-6h-azepinoä5,4,3-cdüindol-6-on
RU2344138C2 (ru) 2004-09-22 2009-01-20 Пфайзер Инк. Способ получения ингибиторов поли(адф-рибоза)полимераз
AU2009235426A1 (en) 2008-04-09 2009-10-15 Lek Pharmaceuticals D.D. Granulation of active pharmaceutical ingredients
DK2833973T3 (en) * 2012-04-05 2018-01-02 Vertex Pharma Compounds useful as ATR kinase inhibitors and combination therapies thereof
LT3182975T (lt) 2014-08-22 2025-11-25 Tabletės su didele rukaparibo doze

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120302550A1 (en) * 2010-02-12 2012-11-29 Pfizer Inc. Salts and polymorphs of 8-fluoro-2--1,3,4,5-tetrahydro-6h-azepino[5,4,3-cd]indol-6-one

Non-Patent Citations (1)

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Title
LIU JOYCE F ET AL, GYNECOLOGIC ONCOLOGY, (2014-05-31), vol. 133, no. 2, pages 362-369 *

Also Published As

Publication number Publication date
JP2020002149A (ja) 2020-01-09
NZ728392A (en) 2023-06-30
CN113209033A (zh) 2021-08-06
WO2016028689A1 (en) 2016-02-25
SG11201700265VA (en) 2017-02-27
EP3182975B1 (en) 2025-10-01
US20160051561A1 (en) 2016-02-25
MX367260B (es) 2019-08-12
JP6797980B2 (ja) 2020-12-09
AU2015305696A1 (en) 2017-02-02
EP3182975A4 (en) 2018-04-18
KR20170043597A (ko) 2017-04-21
JP7127101B2 (ja) 2022-08-29
IL249946A0 (en) 2017-03-30
CA2955495A1 (en) 2016-02-25
US20190099430A1 (en) 2019-04-04
CN106794185A (zh) 2017-05-31
LT3182975T (lt) 2025-11-25
JP2017525712A (ja) 2017-09-07
CA2955495C (en) 2023-09-19
PT3182975T (pt) 2025-10-28
AU2019272064B2 (en) 2021-11-18
US20180200260A1 (en) 2018-07-19
RU2017109139A (ru) 2018-09-24
AU2019272064A1 (en) 2019-12-19
MX2017001540A (es) 2017-05-11
US10130636B2 (en) 2018-11-20
RU2017109139A3 (cg-RX-API-DMAC7.html) 2019-03-06
RS67356B1 (sr) 2025-11-28
JP6574477B2 (ja) 2019-09-11
JP2021038242A (ja) 2021-03-11
DK3182975T3 (da) 2025-10-20
IL249946B (en) 2020-05-31
BR112017000865A2 (pt) 2017-12-05
RU2705156C2 (ru) 2019-11-05
US9987285B2 (en) 2018-06-05
KR102803917B1 (ko) 2025-05-07
FI3182975T3 (fi) 2025-11-13
ES3048688T3 (en) 2025-12-11
KR20230097211A (ko) 2023-06-30
EP3182975A1 (en) 2017-06-28

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Legal Events

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FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: PHARMA& SCHWEIZ GMBH

Free format text: FORMER OWNER(S): CLOVIS ONCOLOGY, INC.