AU2015298852A1 - Novel antibodies and uses thereof - Google Patents

Novel antibodies and uses thereof Download PDF

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Publication number
AU2015298852A1
AU2015298852A1 AU2015298852A AU2015298852A AU2015298852A1 AU 2015298852 A1 AU2015298852 A1 AU 2015298852A1 AU 2015298852 A AU2015298852 A AU 2015298852A AU 2015298852 A AU2015298852 A AU 2015298852A AU 2015298852 A1 AU2015298852 A1 AU 2015298852A1
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AU
Australia
Prior art keywords
antibody
antigen
binding fragment
seq
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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AU2015298852A
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English (en)
Inventor
Helena Agerstam
Thoas Fioretos
Marcus Jaras
Cecilia Ann-Christin Malmborg Hager
Kjell Sjostrom
Agneta Svedberg
Karin Von Wachenfeldt
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Cantargia AB
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Cantargia AB
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Publication date
Application filed by Cantargia AB filed Critical Cantargia AB
Publication of AU2015298852A1 publication Critical patent/AU2015298852A1/en
Abandoned legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
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    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • CCHEMISTRY; METALLURGY
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    • C07KPEPTIDES
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    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
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    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
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    • C07K2317/565Complementarity determining region [CDR]
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    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
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    • C07K2317/77Internalization into the cell
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    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • G01N2333/7155Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]

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AU2015298852A 2014-08-06 2015-08-06 Novel antibodies and uses thereof Abandoned AU2015298852A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1413913.3 2014-08-06
GBGB1413913.3A GB201413913D0 (en) 2014-08-06 2014-08-06 Novel antibodies and uses thereof
PCT/EP2015/068208 WO2016020502A1 (en) 2014-08-06 2015-08-06 Novel antibodies and uses thereof

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EP (1) EP3193926B1 (US20040106767A1-20040603-C00005.png)
JP (1) JP6827411B2 (US20040106767A1-20040603-C00005.png)
KR (1) KR20170039685A (US20040106767A1-20040603-C00005.png)
CN (1) CN107074946B (US20040106767A1-20040603-C00005.png)
AU (1) AU2015298852A1 (US20040106767A1-20040603-C00005.png)
BR (1) BR112017002342A2 (US20040106767A1-20040603-C00005.png)
CA (1) CA2955056A1 (US20040106767A1-20040603-C00005.png)
GB (1) GB201413913D0 (US20040106767A1-20040603-C00005.png)
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Families Citing this family (25)

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Publication number Priority date Publication date Assignee Title
GB2472856B (en) 2009-08-21 2012-07-11 Cantargia Ab IL1-RAP modulators and uses thereof
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US20180044425A1 (en) 2018-02-15
US20180355049A1 (en) 2018-12-13
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