AU2015289573A1 - Terminal modifications of polynucleotides - Google Patents
Terminal modifications of polynucleotides Download PDFInfo
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- AU2015289573A1 AU2015289573A1 AU2015289573A AU2015289573A AU2015289573A1 AU 2015289573 A1 AU2015289573 A1 AU 2015289573A1 AU 2015289573 A AU2015289573 A AU 2015289573A AU 2015289573 A AU2015289573 A AU 2015289573A AU 2015289573 A1 AU2015289573 A1 AU 2015289573A1
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- Australia
- Prior art keywords
- mir
- polynucleotide
- polynucleotides
- sequence
- region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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Landscapes
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| HK1217215A1 (zh) | 2013-01-17 | 2016-12-30 | Modernatx, Inc. | 用於改变细胞表型的信号传感器多核苷酸 |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| DK4023249T3 (da) | 2014-04-23 | 2025-01-13 | Modernatx Inc | Nukleinsyrevacciner |
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| WO2016100812A1 (en) * | 2014-12-19 | 2016-06-23 | Moderna Therapeutics, Inc. | Terminal modifications of polynucleotides |
| EP4218805A1 (en) | 2015-07-21 | 2023-08-02 | ModernaTX, Inc. | Infectious disease vaccines |
| US11364292B2 (en) | 2015-07-21 | 2022-06-21 | Modernatx, Inc. | CHIKV RNA vaccines |
| US12150980B2 (en) | 2015-07-30 | 2024-11-26 | Modernatx, Inc. | Concatemeric peptide epitope RNAs |
| US11564893B2 (en) | 2015-08-17 | 2023-01-31 | Modernatx, Inc. | Methods for preparing particles and related compositions |
| CA3001003A1 (en) | 2015-10-05 | 2017-04-13 | Modernatx, Inc. | Methods for therapeutic administration of messenger ribonucleic acid drugs |
| WO2017070624A1 (en) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Tropical disease vaccines |
| MA52645B1 (fr) | 2015-10-22 | 2022-06-30 | Modernatx Inc | Vaccins contre le virus respiratoire |
| MA46316A (fr) | 2015-10-22 | 2021-03-24 | Modernatx Inc | Vaccin contre le cytomégalovirus humain |
| CN117731769A (zh) | 2015-10-22 | 2024-03-22 | 摩登纳特斯有限公司 | 用于水痘带状疱疹病毒(vzv)的核酸疫苗 |
| AU2016342376A1 (en) | 2015-10-22 | 2018-06-07 | Modernatx, Inc. | Sexually transmitted disease vaccines |
| MD3386484T2 (ro) | 2015-12-10 | 2022-11-30 | Modernatx Inc | Compoziții și metode de livrare a unor agenți terapeutici |
| KR102608220B1 (ko) | 2016-05-06 | 2023-11-29 | 아이오니스 파마수티컬즈, 인코포레이티드 | Glp-1 수용체 리간드 모이어티 컨쥬게이트된 올리고뉴클레오티드 및 이의 용도 |
| WO2017201342A1 (en) * | 2016-05-18 | 2017-11-23 | Modernatx, Inc. | Polynucleotides encoding jagged1 for the treatment of alagille syndrome |
| MA45053A (fr) * | 2016-05-18 | 2019-03-27 | Modernatx Inc | Polynucléotides codant pour un régulateur de conductance transmembranaire de fibrose kystique pour le traitement de la fibrose kystique |
| KR20190026819A (ko) | 2016-07-07 | 2019-03-13 | 루비우스 테라퓨틱스, 아이엔씨. | 외인성 rna를 발현하는 치료용 세포 시스템과 관련된 조성물 및 방법 |
| CN109937253B (zh) | 2016-09-14 | 2023-06-30 | 摩登纳特斯有限公司 | 高纯度rna组合物及其制备方法 |
| WO2018075980A1 (en) | 2016-10-21 | 2018-04-26 | Modernatx, Inc. | Human cytomegalovirus vaccine |
| US10925958B2 (en) | 2016-11-11 | 2021-02-23 | Modernatx, Inc. | Influenza vaccine |
| BR112019010486A2 (pt) | 2016-11-28 | 2019-09-10 | Napajen Pharma Inc | sirna quimicamente modificado |
| MA50335A (fr) | 2016-12-08 | 2020-08-19 | Modernatx Inc | Vaccins à acide nucléique contre des virus respiratoires |
| US11384352B2 (en) | 2016-12-13 | 2022-07-12 | Modernatx, Inc. | RNA affinity purification |
| EP3595713A4 (en) | 2017-03-15 | 2021-01-13 | ModernaTX, Inc. | Respiratory syncytial virus vaccine |
| WO2018170270A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Varicella zoster virus (vzv) vaccine |
| US11752206B2 (en) | 2017-03-15 | 2023-09-12 | Modernatx, Inc. | Herpes simplex virus vaccine |
| US11576961B2 (en) | 2017-03-15 | 2023-02-14 | Modernatx, Inc. | Broad spectrum influenza virus vaccine |
| US20200030432A1 (en) | 2017-03-17 | 2020-01-30 | Modernatx, Inc. | Zoonotic disease rna vaccines |
| EP3607074A4 (en) | 2017-04-05 | 2021-07-07 | Modernatx, Inc. | REDUCTION OR ELIMINATION OF IMMUNE RESPONSES TO NON-INTRAVENOUS THERAPEUTIC PROTEINS, FOR EXAMPLE SUBCUTANEOUSLY |
| WO2018186704A1 (ko) * | 2017-04-06 | 2018-10-11 | 포항공과대학교 산학협력단 | 무항생제 플라스미드 유지 시스템에서 플라스미드 카피 수의 정량적 조절 방법 |
| US11390854B2 (en) | 2017-05-09 | 2022-07-19 | Fundacion Para La Investigacion Medica Aplicada | Human porphobilinogen deaminase derived proteins and polynucleotides and uses thereof |
| US11786607B2 (en) | 2017-06-15 | 2023-10-17 | Modernatx, Inc. | RNA formulations |
| US11866696B2 (en) | 2017-08-18 | 2024-01-09 | Modernatx, Inc. | Analytical HPLC methods |
| US11912982B2 (en) | 2017-08-18 | 2024-02-27 | Modernatx, Inc. | Methods for HPLC analysis |
| WO2019036682A1 (en) | 2017-08-18 | 2019-02-21 | Modernatx, Inc. | RNA VARIANTS POLYMERASE |
| MX2020002348A (es) | 2017-08-31 | 2020-10-08 | Modernatx Inc | Métodos de elaboración de nanopartículas lipídicas. |
| GB201714430D0 (en) | 2017-09-07 | 2017-10-25 | Micol Romain | Compositions and processes for targeted delivery and expression and modulation of therapeutic components in tissue |
| MA50253A (fr) | 2017-09-14 | 2020-07-22 | Modernatx Inc | Vaccins à arn contre le virus zika |
| CN119876131A (zh) * | 2017-11-08 | 2025-04-25 | Ionis制药公司 | Glp-1受体配体部分缀合的寡核苷酸及其用途 |
| WO2019126144A1 (en) | 2017-12-22 | 2019-06-27 | North Carolina State University | Polymeric fluorophores, compositions comprising the same, and methods of preparing and using the same |
| US11911453B2 (en) | 2018-01-29 | 2024-02-27 | Modernatx, Inc. | RSV RNA vaccines |
| EP4008333A1 (en) | 2018-02-19 | 2022-06-08 | Combined Therapeutics, Inc. | Compositions and methods for organ-protective expression and modulation of coding ribonucleic acids |
| CA3113025A1 (en) | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | Peg lipids and uses thereof |
| EP4509118A3 (en) | 2018-09-19 | 2025-05-14 | ModernaTX, Inc. | High-purity peg lipids and uses thereof |
| US12090235B2 (en) | 2018-09-20 | 2024-09-17 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| US11351242B1 (en) | 2019-02-12 | 2022-06-07 | Modernatx, Inc. | HMPV/hPIV3 mRNA vaccine composition |
| JP2022521094A (ja) | 2019-02-20 | 2022-04-05 | モデルナティエックス インコーポレイテッド | 共転写キャッピング用rnaポリメラーゼバリアント |
| US11851694B1 (en) | 2019-02-20 | 2023-12-26 | Modernatx, Inc. | High fidelity in vitro transcription |
| EP3938507A4 (en) | 2019-03-11 | 2023-02-22 | ModernaTX, Inc. | PROCEDURE FOR IN VITRO FED BATCH TRANSCRIPTION |
| MA55321A (fr) | 2019-03-15 | 2022-01-19 | Modernatx Inc | Vaccins à base d'arn contre le vih |
| WO2020204130A1 (ja) * | 2019-04-05 | 2020-10-08 | 国立大学法人京都大学 | Rnaのキャッピング方法、修飾rnaの製造方法、及び修飾rna |
| WO2021001377A1 (en) | 2019-07-02 | 2021-01-07 | Fundacion Para La Investigacion Medica Aplicada | cPLA2e INDUCING AGENTS AND USES THEREOF |
| JP2023522249A (ja) | 2020-04-22 | 2023-05-29 | ビオンテック・ソシエタス・エウロパエア | コロナウイルスワクチン |
| WO2022035621A1 (en) | 2020-07-31 | 2022-02-17 | Combined Therapeutics, Inc. | Compositions and methods for improved vaccination |
| US11406703B2 (en) | 2020-08-25 | 2022-08-09 | Modernatx, Inc. | Human cytomegalovirus vaccine |
| US12329811B2 (en) | 2021-01-11 | 2025-06-17 | Modernatx, Inc. | Seasonal RNA influenza virus vaccines |
| US11524023B2 (en) | 2021-02-19 | 2022-12-13 | Modernatx, Inc. | Lipid nanoparticle compositions and methods of formulating the same |
| US20220363937A1 (en) | 2021-05-14 | 2022-11-17 | Armstrong World Industries, Inc. | Stabilization of antimicrobial coatings |
| TW202317766A (zh) * | 2021-06-24 | 2023-05-01 | 南韓商韓美藥品股份有限公司 | 非自然發生的5’-非轉譯區及3’-非轉譯區及其用途 |
| US20240325426A1 (en) * | 2021-06-30 | 2024-10-03 | Kyowa Kirin Co., Ltd. | Polynucleotide and pharmaceutical composition |
| EP4379055A4 (en) * | 2021-07-27 | 2025-08-06 | Sk Bioscience Co Ltd | MRNA FOR PROTEIN EXPRESSION AND TEMPLATE FOR IT |
| KR20240090727A (ko) | 2021-10-22 | 2024-06-21 | 세일 바이오메디슨스, 인크. | Mrna 백신 조성물 |
| AU2022398450A1 (en) | 2021-11-23 | 2024-06-06 | Sail Biomedicines, Inc. | A bacteria-derived lipid composition and use thereof |
| US12186387B2 (en) | 2021-11-29 | 2025-01-07 | BioNTech SE | Coronavirus vaccine |
| JP2025500373A (ja) | 2021-12-20 | 2025-01-09 | セイル バイオメディシンズ インコーポレイテッド | Mrna治療用組成物 |
| WO2023177904A1 (en) | 2022-03-18 | 2023-09-21 | Modernatx, Inc. | Sterile filtration of lipid nanoparticles and filtration analysis thereof for biological applications |
| JP2025519096A (ja) | 2022-05-25 | 2025-06-24 | フラッグシップ パイオニアリング イノベーションズ セブン,エルエルシー | 遺伝的ドライバーを調節するための組成物及び方法 |
| AU2023275550A1 (en) | 2022-05-25 | 2024-11-21 | Flagship Pioneering Innovations Vii, Llc | Compositions and methods for modulating cytokines |
| AU2023276714A1 (en) | 2022-05-25 | 2024-11-21 | Flagship Pioneering Innovations Vii, Llc | Compositions and methods for modulation of immune responses |
| CN119947754A (zh) | 2022-05-25 | 2025-05-06 | 旗舰创业创新第七有限责任公司 | 用于调节肿瘤抑制因子和癌基因的组合物和方法 |
| EP4650780A2 (en) | 2022-05-25 | 2025-11-19 | Flagship Pioneering Innovations VII, LLC | Compositions and methods for modulating circulating factors |
| US11878055B1 (en) | 2022-06-26 | 2024-01-23 | BioNTech SE | Coronavirus vaccine |
| WO2024035733A1 (en) * | 2022-08-08 | 2024-02-15 | The Curators Of The University Of Missouri | Fasl-modified plg scaffolds enhances differentiation of stem cell derived beta cells |
| EP4577519A1 (en) | 2022-08-23 | 2025-07-02 | ModernaTX, Inc. | Methods for purification of ionizable lipids |
| JP2025537750A (ja) | 2022-11-10 | 2025-11-20 | セイル バイオメディシンズ インコーポレイテッド | 脂質ナノ粒子または脂質再構成天然メッセンジャーパックを含むrna組成物 |
| TW202430215A (zh) | 2022-12-14 | 2024-08-01 | 美商旗艦先鋒創新有限責任(Vii)公司 | 用於將治療劑遞送至骨之組成物和方法 |
| AU2024212425A1 (en) | 2023-01-27 | 2025-08-07 | Sail Biomedicines, Inc. | A modified lipid composition and uses thereof |
| WO2024220752A2 (en) | 2023-04-19 | 2024-10-24 | Sail Biomedicines, Inc. | Rna therapeutic compositions |
| WO2024220625A1 (en) | 2023-04-19 | 2024-10-24 | Sail Biomedicines, Inc. | Delivery of polynucleotides from lipid nanoparticles comprising rna and ionizable lipids |
| WO2024220712A2 (en) | 2023-04-19 | 2024-10-24 | Sail Biomedicines, Inc. | Vaccine compositions |
| WO2024238726A1 (en) | 2023-05-16 | 2024-11-21 | Omega Therapeutics, Inc. | Methods and compositions for modulating methylation of a target gene |
| WO2024238723A1 (en) | 2023-05-16 | 2024-11-21 | Omega Therapeutics, Inc. | Methods and compositions for modulating pcsk9 expression |
| WO2025019742A1 (en) | 2023-07-19 | 2025-01-23 | Omega Therapeutics, Inc. | Methods and compositions for modulating ctnnb1 expression |
| AR133964A1 (es) * | 2023-09-27 | 2025-11-19 | Hanmi Pharmaceutical Co Ltd | Región no traducida en 5 no natural y uso de la misma |
| WO2025194138A1 (en) | 2024-03-14 | 2025-09-18 | Tessera Therapeutics, Inc. | St1cas9 compositions and methods for modulating a genome |
| WO2025235563A1 (en) | 2024-05-07 | 2025-11-13 | Omega Therapeutics, Inc. | Epigenetic modulation for upregulation of genes |
Family Cites Families (2)
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| CA2892529C (en) * | 2012-11-26 | 2023-04-25 | Moderna Therapeutics, Inc. | Terminally modified rna |
| US20160022840A1 (en) * | 2013-03-09 | 2016-01-28 | Moderna Therapeutics, Inc. | Heterologous untranslated regions for mrna |
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- 2015-07-17 WO PCT/US2015/040835 patent/WO2016011306A2/en not_active Ceased
- 2015-07-17 CA CA2955375A patent/CA2955375A1/en not_active Abandoned
- 2015-07-17 EP EP15821578.0A patent/EP3169783A4/en not_active Withdrawn
- 2015-07-17 JP JP2017502776A patent/JP2017523777A/ja active Pending
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| EP3169783A2 (en) | 2017-05-24 |
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| EP3169783A4 (en) | 2018-10-03 |
| CA2955375A1 (en) | 2016-01-21 |
| US20170202979A1 (en) | 2017-07-20 |
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