AU2015280362B2 - Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (CSF1R) - Google Patents

Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (CSF1R) Download PDF

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Publication number
AU2015280362B2
AU2015280362B2 AU2015280362A AU2015280362A AU2015280362B2 AU 2015280362 B2 AU2015280362 B2 AU 2015280362B2 AU 2015280362 A AU2015280362 A AU 2015280362A AU 2015280362 A AU2015280362 A AU 2015280362A AU 2015280362 B2 AU2015280362 B2 AU 2015280362B2
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val
leu
thr
gly
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AU2015280362A
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AU2015280362A1 (en
Inventor
Julie Hambleton
Emma Masteller
Robert Sikorski
Hong Xiang
James ZANGHI
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Five Prime Therapeutics Inc
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Five Prime Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2015280362A 2014-06-23 2015-06-18 Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (CSF1R) Ceased AU2015280362B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462015710P 2014-06-23 2014-06-23
US62/015,710 2014-06-23
PCT/US2015/036419 WO2015200089A1 (en) 2014-06-23 2015-06-18 Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)

Publications (2)

Publication Number Publication Date
AU2015280362A1 AU2015280362A1 (en) 2016-12-22
AU2015280362B2 true AU2015280362B2 (en) 2021-03-04

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AU2015280362A Ceased AU2015280362B2 (en) 2014-06-23 2015-06-18 Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (CSF1R)

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US (2) US10975153B2 (cg-RX-API-DMAC7.html)
EP (1) EP3157957A1 (cg-RX-API-DMAC7.html)
JP (2) JP6964410B2 (cg-RX-API-DMAC7.html)
KR (2) KR20170016501A (cg-RX-API-DMAC7.html)
CN (2) CN106795222A (cg-RX-API-DMAC7.html)
AU (1) AU2015280362B2 (cg-RX-API-DMAC7.html)
BR (1) BR112016029460A2 (cg-RX-API-DMAC7.html)
CA (1) CA2951156A1 (cg-RX-API-DMAC7.html)
EA (1) EA037561B1 (cg-RX-API-DMAC7.html)
IL (1) IL249393B (cg-RX-API-DMAC7.html)
MX (1) MX391735B (cg-RX-API-DMAC7.html)
SG (2) SG11201610672YA (cg-RX-API-DMAC7.html)
WO (1) WO2015200089A1 (cg-RX-API-DMAC7.html)

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US20130302322A1 (en) 2012-05-11 2013-11-14 Five Prime Therapeutics, Inc. Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)
JP2020517256A (ja) * 2017-04-19 2020-06-18 エルスター セラピューティクス， インコーポレイテッド 多重特異性分子およびその使用
CN108948199B (zh) * 2018-07-18 2019-06-21 博奥信生物技术（南京）有限公司 抗人csf-1r单克隆抗体及其用途
CN109053887B (zh) * 2018-07-18 2019-07-23 博奥信生物技术（南京）有限公司 一种抗人csf-1r单克隆抗体及用途
EP3833762A4 (en) 2018-08-09 2022-09-28 Verseau Therapeutics, Inc. Oligonucleotide compositions for targeting ccr2 and csf1r and uses thereof
JP2023553538A (ja) * 2020-12-14 2023-12-21 エーマックス バイオ， インコーポレイテッド 抗ｃｓｆ１および抗ｃｓｆ１ｒ抗体の高濃度製剤

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WO2014036357A1 (en) * 2012-08-31 2014-03-06 Five Prime Therapeutics, Inc. Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)

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Also Published As

Publication number Publication date
MX391735B (es) 2025-03-21
WO2015200089A1 (en) 2015-12-30
CA2951156A1 (en) 2015-12-30
US20170152320A1 (en) 2017-06-01
EA037561B1 (ru) 2021-04-14
KR20230086809A (ko) 2023-06-15
JP2020169179A (ja) 2020-10-15
CN113350501A (zh) 2021-09-07
IL249393B (en) 2022-02-01
US20210317219A1 (en) 2021-10-14
IL249393A0 (en) 2017-02-28
SG11201610672YA (en) 2017-01-27
KR20170016501A (ko) 2017-02-13
BR112016029460A2 (pt) 2017-10-24
US10975153B2 (en) 2021-04-13
AU2015280362A1 (en) 2016-12-22
SG10201811475YA (en) 2019-02-27
MX2016016664A (es) 2017-03-20
EA201692482A1 (ru) 2017-05-31
CN106795222A (zh) 2017-05-31
EP3157957A1 (en) 2017-04-26
JP2017520562A (ja) 2017-07-27
JP6964410B2 (ja) 2021-11-10

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