AU2015279105B2 - Methods for treating, diagnosing and prognosing a haematological malignancy - Google Patents
Methods for treating, diagnosing and prognosing a haematological malignancy Download PDFInfo
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- AU2015279105B2 AU2015279105B2 AU2015279105A AU2015279105A AU2015279105B2 AU 2015279105 B2 AU2015279105 B2 AU 2015279105B2 AU 2015279105 A AU2015279105 A AU 2015279105A AU 2015279105 A AU2015279105 A AU 2015279105A AU 2015279105 B2 AU2015279105 B2 AU 2015279105B2
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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| JP7002245B2 (ja) * | 2017-08-10 | 2022-01-20 | シスメックス株式会社 | 血液分析装置、血液分析方法およびプログラム |
| WO2019088926A1 (en) * | 2017-11-01 | 2019-05-09 | National University Of Singapore | Use of serotonergic drugs to treat virus-induced thrombocytopenia |
| WO2019141673A1 (en) | 2018-01-18 | 2019-07-25 | Leukos Biotech, S. L. | Apomorphine·palmitic acid cocrystal solid particle crystalline form |
| US11034751B1 (en) | 2018-01-30 | 2021-06-15 | Flagship Pioneering Innovations V, Inc. | Methods and compositions for treating cancer using serotonin receptor inhibitors |
| CN111257558B (zh) * | 2020-01-19 | 2021-08-24 | 江苏省人民医院（南京医科大学第一附属医院） | 基于机器学习的慢性淋巴细胞白血病肿瘤细胞识别方法 |
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| WO2010135468A1 (en) * | 2009-05-19 | 2010-11-25 | Vivia Biotech S.L. | Methods for providing personalized medicine tests ex vivo for hematological neoplasms |
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| DE1668055B2 (de) | 1967-03-10 | 1973-09-06 | Farbwerke Hoechst AG, vormals Mei ster Lucius & Bruning, 6000 Frankfurt | Basisch substituierte cyclopentylphenolaether, deren salze mit physiologisch vertraeglichen saeuren und verfahren zu deren herstellung |
| GB1308191A (en) | 1970-04-06 | 1973-02-21 | Science Union & Cie | Thiochroman derivatives and a process for preparing them |
| CA2134038C (en) | 1994-06-16 | 1997-06-03 | David Taiwai Wong | Potentiation of drug response |
| KR20040055311A (ko) * | 2002-12-20 | 2004-06-26 | 주식회사 피앤아이 컨설팅 | 악성혈액종양 진단용 칩 및 이를 이용한 예후판단 시스템 |
| DE602004014254D1 (de) * | 2003-02-17 | 2008-07-17 | Bayer Healthcare Ag | Diagnostik- und therapie- verfahren von mit 5-ht1f rezeptor verbundenen haematologischen krankheiten |
| WO2008098351A1 (en) * | 2007-02-14 | 2008-08-21 | University Health Network | Treatment of d-cyclin mediated proliferative diseases and hemotological malignancies |
| WO2008146101A1 (en) * | 2007-06-01 | 2008-12-04 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Ligands of hvem for treating hematologic malignancies and autoimmune diseases |
| WO2009109911A1 (en) * | 2008-03-04 | 2009-09-11 | Pfizer Limited | Methods of treating chronic pain |
| US10603315B2 (en) * | 2013-11-26 | 2020-03-31 | Technion Research And Development Foundation Limited | Neuronal modulation |
| US20150197839A1 (en) * | 2014-01-13 | 2015-07-16 | Maria Celeste Rellamas Tria | Forming conductive pattern using titania sol-gel |
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Patent Citations (2)
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|---|---|---|---|---|
| WO2003063866A1 (en) * | 2002-02-01 | 2003-08-07 | The University Of Birmingham | Agents which interact with a serotonin transporter for the treatment of cancer |
| WO2010135468A1 (en) * | 2009-05-19 | 2010-11-25 | Vivia Biotech S.L. | Methods for providing personalized medicine tests ex vivo for hematological neoplasms |
Non-Patent Citations (1)
| Title |
|---|
| KONDO Y ET AL, "SUPPRESSION OF TUMOR CELL GROWTH AND MITOGEN RESPONSE BY APORPHINE ALKALOIDS DICENTRINE GLAUCINE CORYDINE AND APOMORPHINE", JOURNAL OF PHARMACOBIO-DYNAMICS, (1990), vol. 13, no. 7, ISSN 0386-846X, pages 426 - 431 * |
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