AU2015265916B2 - Pharmaceutical combinations for immunotherapy - Google Patents

Pharmaceutical combinations for immunotherapy Download PDF

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Publication number
AU2015265916B2
AU2015265916B2 AU2015265916A AU2015265916A AU2015265916B2 AU 2015265916 B2 AU2015265916 B2 AU 2015265916B2 AU 2015265916 A AU2015265916 A AU 2015265916A AU 2015265916 A AU2015265916 A AU 2015265916A AU 2015265916 B2 AU2015265916 B2 AU 2015265916B2
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ntr
pdcs
cells
disease
cell
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AU2015265916A1 (en
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Sebastian Brenner
Cornelia Richter
Martin Ryser
Sebastian Thieme
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Technische Universitaet Dresden
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Technische Universitaet Dresden
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AU2015265916A 2014-05-28 2015-05-28 Pharmaceutical combinations for immunotherapy Ceased AU2015265916B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14170362.9A EP2950095B1 (de) 2014-05-28 2014-05-28 Zellenbasierte Test- und Screeningverfahren auf Modulatoren von p75NTR-Signalisierung
EP14170362.9 2014-05-28
PCT/EP2015/061851 WO2015181298A1 (en) 2014-05-28 2015-05-28 Pharmaceutical combinations for immunotherapy

Publications (2)

Publication Number Publication Date
AU2015265916A1 AU2015265916A1 (en) 2016-12-22
AU2015265916B2 true AU2015265916B2 (en) 2021-07-29

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ID=50884248

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Application Number Title Priority Date Filing Date
AU2015265916A Ceased AU2015265916B2 (en) 2014-05-28 2015-05-28 Pharmaceutical combinations for immunotherapy

Country Status (7)

Country Link
US (2) US20170189522A1 (de)
EP (1) EP2950095B1 (de)
JP (2) JP6720147B2 (de)
AU (1) AU2015265916B2 (de)
CA (1) CA2949885A1 (de)
ES (1) ES2699410T3 (de)
WO (1) WO2015181298A1 (de)

Families Citing this family (8)

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US10760054B2 (en) * 2014-12-29 2020-09-01 Restem Llc Natural killer cells and methods for enhancing viability, proliferation and cytotoxicity of same following cryopreservation
US11249081B2 (en) 2016-08-31 2022-02-15 Agency For Science, Technology And Research Methods for the identification, targeting and isolation of human dendritic cell (DC) precursors “pre-DC” and their uses thereof
CN106614260B (zh) * 2016-09-06 2019-11-08 广东省人民医院 一种C5aR基因敲除小鼠cGVHD模型的建立方法
CN110234401B (zh) 2016-11-09 2024-03-01 德克萨斯大学系统董事会 用于适应性免疫调节的方法和组合物
US20190336535A1 (en) 2017-01-17 2019-11-07 Tufts Medical Center, Inc. Adoptive transfer of plasmacytoid dendritic cells to prevent or treat ocular diseases and conditions
CN108728444A (zh) * 2017-04-18 2018-11-02 长春华普生物技术股份有限公司 免疫调节性多核苷酸及其应用
US20220362292A1 (en) * 2019-07-26 2022-11-17 Tufts Medical Center, Inc. Adoptive transfer of plasmacytoid dendritic cells to prevent or treat hair loss
GB202014920D0 (en) * 2020-09-22 2020-11-04 Unikum Therapeutics Aps Methods for treating cancer and autoimmune and inflammatory diseases

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100029585A1 (en) * 2008-08-01 2010-02-04 Howbert J Jeffry Toll-like receptor agonist formulations and their use
WO2012101664A1 (en) * 2011-01-24 2012-08-02 Ospedale Pediatrico Bambino Gesu´ Use of at least one p75ntr receptor inhibitor, alone or in association with at least one trka receptor activator, or of at least one trka receptor activator, for the treatment of chronic inflammatory diseases

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0890105B1 (de) * 1996-03-29 2006-11-22 The Trustees Of Boston University Mit Alzheimer Krankheit verknüpften Verfahren zur Diagnose, zur Herstellung von Medikamenten und zum Screenen von Substanzen sowie aus Beta-Amyloid abgeleiteten Peptiden
DK0994721T3 (da) * 1997-05-01 2007-04-02 Protechtion Unltd Inc Nervevækstfaktor som vaccineadjuvans
IL139574A0 (en) * 1998-05-18 2002-02-10 Applied Research Systems TNF-RII (p75) AGONISTS FOR TREATING ASTHMA AND OTHER ALLERGIC CONDITIONS
JP2006519020A (ja) * 2003-02-27 2006-08-24 スリーエム イノベイティブ プロパティズ カンパニー Ｔｌｒ介在生物活性の選択的調節
CA2571130C (en) * 2004-07-14 2014-08-19 Janssen Pharmaceutica N.V. P75ntr screening assay for indentifying modulators of apoptosis
FR2932481B1 (fr) 2008-06-13 2010-10-08 Sanofi Aventis Derives de 4-{2-°4-phenyl-3,6-dihydro-2h-pyridin-1-yl!-2- oxo-alkyl}-1-piperazin-2-one, leur preparation et leur application en therapeutique.
GB201009273D0 (en) * 2010-06-03 2010-07-21 Glaxosmithkline Biolog Sa Novel vaccine
MX340233B (es) * 2010-08-31 2016-07-01 Bionure Farma S L Agonistas de receptores de neurotrofina y sus usos como medicamentos.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100029585A1 (en) * 2008-08-01 2010-02-04 Howbert J Jeffry Toll-like receptor agonist formulations and their use
WO2012101664A1 (en) * 2011-01-24 2012-08-02 Ospedale Pediatrico Bambino Gesu´ Use of at least one p75ntr receptor inhibitor, alone or in association with at least one trka receptor activator, or of at least one trka receptor activator, for the treatment of chronic inflammatory diseases

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