AU2015255714B2 - Anti-viral compounds, pharmaceutical compositions, and methods of use thereof - Google Patents

Anti-viral compounds, pharmaceutical compositions, and methods of use thereof Download PDF

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Publication number
AU2015255714B2
AU2015255714B2 AU2015255714A AU2015255714A AU2015255714B2 AU 2015255714 B2 AU2015255714 B2 AU 2015255714B2 AU 2015255714 A AU2015255714 A AU 2015255714A AU 2015255714 A AU2015255714 A AU 2015255714A AU 2015255714 B2 AU2015255714 B2 AU 2015255714B2
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AU
Australia
Prior art keywords
virus
compound
compounds
formula
group
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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AU2015255714A
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English (en)
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AU2015255714A1 (en
Inventor
Kristin M. Bedard
Kerry W. Fowler
Shawn P. Iadonato
Shari KAISER
Ikenna MADU
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Kineta Inc
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Kineta Inc
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Publication of AU2015255714A1 publication Critical patent/AU2015255714A1/en
Application granted granted Critical
Publication of AU2015255714B2 publication Critical patent/AU2015255714B2/en
Priority to AU2020201815A priority Critical patent/AU2020201815A1/en
Priority to AU2020204324A priority patent/AU2020204324A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2015255714A 2014-05-09 2015-05-08 Anti-viral compounds, pharmaceutical compositions, and methods of use thereof Ceased AU2015255714B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2020201815A AU2020201815A1 (en) 2014-05-09 2020-03-12 Anti-viral compounds, pharmaceutical compositions, and methods of use thereof
AU2020204324A AU2020204324A1 (en) 2014-05-09 2020-06-29 Anti-viral compounds, pharmaceutical compositions, and methods of use thereof

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461991418P 2014-05-09 2014-05-09
US61/991,418 2014-05-09
US201562177900P 2015-03-25 2015-03-25
US62/177,900 2015-03-25
PCT/US2015/030014 WO2015172099A1 (en) 2014-05-09 2015-05-08 Anti-viral compounds, pharmaceutical compositions, and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2020201815A Division AU2020201815A1 (en) 2014-05-09 2020-03-12 Anti-viral compounds, pharmaceutical compositions, and methods of use thereof

Publications (2)

Publication Number Publication Date
AU2015255714A1 AU2015255714A1 (en) 2016-10-20
AU2015255714B2 true AU2015255714B2 (en) 2019-12-12

Family

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Family Applications (3)

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AU2015255714A Ceased AU2015255714B2 (en) 2014-05-09 2015-05-08 Anti-viral compounds, pharmaceutical compositions, and methods of use thereof
AU2020201815A Abandoned AU2020201815A1 (en) 2014-05-09 2020-03-12 Anti-viral compounds, pharmaceutical compositions, and methods of use thereof
AU2020204324A Abandoned AU2020204324A1 (en) 2014-05-09 2020-06-29 Anti-viral compounds, pharmaceutical compositions, and methods of use thereof

Family Applications After (2)

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AU2020201815A Abandoned AU2020201815A1 (en) 2014-05-09 2020-03-12 Anti-viral compounds, pharmaceutical compositions, and methods of use thereof
AU2020204324A Abandoned AU2020204324A1 (en) 2014-05-09 2020-06-29 Anti-viral compounds, pharmaceutical compositions, and methods of use thereof

Country Status (9)

Country Link
US (3) US9884876B2 (enExample)
EP (1) EP3139920A4 (enExample)
JP (1) JP6419313B2 (enExample)
CN (1) CN106456615B (enExample)
AU (3) AU2015255714B2 (enExample)
CA (1) CA2948178A1 (enExample)
MX (2) MX2016014642A (enExample)
TW (1) TW201623265A (enExample)
WO (1) WO2015172099A1 (enExample)

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CA3058966A1 (en) 2017-04-14 2018-10-18 Tollnine, Inc. Immunomodulating polynucleotides, antibody conjugates thereof, and methods of their use
TW202021956A (zh) * 2018-08-09 2020-06-16 美商奇尼塔公司 視黃酸誘導基因"rig-i"途徑之活化劑及其使用方法
TW202035426A (zh) * 2018-08-17 2020-10-01 美商奇尼塔公司 視黃酸誘導基因"rig-i"途徑之活化劑及其使用方法
CA3118339A1 (en) * 2018-11-02 2020-05-07 Aicuris Gmbh & Co. Kg Novel urea 6,7-dihydro-4h-thiazolo[5,4-c]pyridines active against the hepatitis b virus (hbv)
EP3980400B1 (en) * 2019-06-05 2025-08-06 Emory University Peptidomimetics for the treatment of coronavirus and picornavirus infections
WO2021007283A1 (en) * 2019-07-09 2021-01-14 Regents Of The University Of Minnesota Potentiation of antiviral nucleobases as rna virus therapy
JP2022550454A (ja) * 2019-10-02 2022-12-01 ユニバーシティ オブ ワシントン Ｂ型肝炎ウイルス感染の治療のための組成物及び方法
IL295759A (en) 2020-02-28 2022-10-01 Tallac Therapeutics Inc Transglutaminase mediated coupling
WO2021198980A1 (en) 2020-04-04 2021-10-07 Pfizer Inc. Methods of treating coronavirus disease 2019
TWI807291B (zh) 2020-04-05 2023-07-01 美商輝瑞大藥廠 用於治療covid-19之化合物及方法
US12358897B2 (en) 2020-04-05 2025-07-15 Pfizer Inc. Compounds and method of treating COVID-19
WO2021205296A1 (en) 2020-04-05 2021-10-14 Pfizer Inc. Method of treating covid-19
CA3176626A1 (en) 2020-05-08 2021-11-11 David Dornan Elastase-substrate, peptide linker immunoconjugates, and uses thereof
JP2023526625A (ja) 2020-05-19 2023-06-22 キャリーオペ，インク． Ａｍｐｋアクチベーター
CN113831301B (zh) * 2020-06-08 2023-06-06 沈阳药科大学 苯并噻唑类衍生物及其用途
CN116390925A (zh) 2020-06-26 2023-07-04 卡尔优普公司 Ampk活化剂
US12577240B2 (en) 2020-07-11 2026-03-17 Pfizer Inc. Antiviral heteroaryl ketone derivatives
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds
US12527773B2 (en) * 2020-10-15 2026-01-20 Baden-Württemberg Stiftung Gmbh Flavi-block: a pan-flavivirus inhibitor
JP2024508817A (ja) * 2021-02-24 2024-02-28 エフ． ホフマン－ラ ロシュ アーゲー Ｂ型肝炎ウイルス感染症の処置および予防のためのベンゾチアゾリルビシクロ［１．１．１］ペンタン誘導体
CN117460738A (zh) * 2021-03-24 2024-01-26 阿纳韦克斯生命科学公司 冠状病毒感染的预防和治疗
US20250304559A1 (en) 2021-03-30 2025-10-02 Pfizer Inc. Ether-Linked Antiviral Compounds
TWI869780B (zh) 2022-03-02 2025-01-11 美商輝瑞大藥廠 用於篩檢人類個體之呼吸疾病、監測人類個體之呼吸病況以及提供決策支援之方法及電腦化系統
WO2024149990A1 (en) 2023-01-10 2024-07-18 Oxford University Innovation Limited Nirmatrelvir analogs as 3c like protease inhibitors for treating viral infections
KR20260021033A (ko) 2023-06-09 2026-02-12 화이자 인코포레이티드 N-(메톡시카보닐)-3-메틸-l-발릴-(4r)-n-｛(1s)-1-시아노-2-[(3s)-2-옥소피롤리딘-3-일]에틸｝-4-(트리플루오로메틸)-l-프롤린아미드의고체 형태 및 이의 용매화물
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Also Published As

Publication number Publication date
US20190002477A1 (en) 2019-01-03
US9884876B2 (en) 2018-02-06
MX2020005187A (es) 2020-08-20
AU2020204324A1 (en) 2020-07-16
AU2015255714A1 (en) 2016-10-20
US20200270274A1 (en) 2020-08-27
MX2016014642A (es) 2017-05-25
CN106456615A (zh) 2017-02-22
EP3139920A4 (en) 2017-11-01
CN106456615B (zh) 2020-10-27
JP2017515901A (ja) 2017-06-15
JP6419313B2 (ja) 2018-11-07
EP3139920A1 (en) 2017-03-15
AU2020201815A1 (en) 2020-04-02
CA2948178A1 (en) 2015-11-12
TW201623265A (zh) 2016-07-01
WO2015172099A1 (en) 2015-11-12
US20170057978A1 (en) 2017-03-02

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