AU2015254558B2 - Ion channel modulators and uses thereof - Google Patents

Ion channel modulators and uses thereof Download PDF

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Publication number
AU2015254558B2
AU2015254558B2 AU2015254558A AU2015254558A AU2015254558B2 AU 2015254558 B2 AU2015254558 B2 AU 2015254558B2 AU 2015254558 A AU2015254558 A AU 2015254558A AU 2015254558 A AU2015254558 A AU 2015254558A AU 2015254558 B2 AU2015254558 B2 AU 2015254558B2
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AU
Australia
Prior art keywords
prt
antibody
cdr3
sequence
cells
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AU2015254558A
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English (en)
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AU2015254558A1 (en
Inventor
James BUTTON
Claire Dobson
Maria Groves
Ling Huang
Clare Jones
John LINLEY
Yoko Shibata
Harm Jan SNIJDER
Sudharsan SRIDHARAN
Wendy A. Williams
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MedImmune Ltd
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MedImmune Ltd
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Publication of AU2015254558A1 publication Critical patent/AU2015254558A1/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2015254558A 2014-05-02 2015-05-02 Ion channel modulators and uses thereof Active AU2015254558B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461987929P 2014-05-02 2014-05-02
US61/987,929 2014-05-02
PCT/EP2015/059633 WO2015166105A2 (en) 2014-05-02 2015-05-02 Ion channel modulators and uses thereof

Publications (2)

Publication Number Publication Date
AU2015254558A1 AU2015254558A1 (en) 2016-12-08
AU2015254558B2 true AU2015254558B2 (en) 2021-02-25

Family

ID=53055033

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015254558A Active AU2015254558B2 (en) 2014-05-02 2015-05-02 Ion channel modulators and uses thereof

Country Status (8)

Country Link
US (2) US10654926B2 (enExample)
EP (2) EP4001310A3 (enExample)
JP (2) JP2017515473A (enExample)
AU (1) AU2015254558B2 (enExample)
BR (1) BR112016025450A2 (enExample)
CA (1) CA2946669A1 (enExample)
ES (1) ES2899754T3 (enExample)
WO (1) WO2015166105A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11266690B2 (en) * 2018-02-01 2022-03-08 Nanjing Iaso Biotherapeutics Co., Ltd. Chimeric antigen receptor (CAR) binding to BCMA, and uses thereof
US12145991B2 (en) 2018-11-02 2024-11-19 Unm Rainforest Innovations Therapeutic antibody fragments, methods of making, and methods of use
WO2020186158A2 (en) * 2019-03-13 2020-09-17 Ulmert Hans David Staffan Prame binding molecules and uses thereof
US12123814B1 (en) * 2019-06-14 2024-10-22 Pierce Biotechnology, Inc. G- protein coupled receptor extraction formulations
WO2021041194A1 (en) * 2019-08-23 2021-03-04 Unm Rainforest Innovations Non-opioid compositions and therapies for pain management
MX2022005983A (es) * 2019-11-18 2022-09-07 Janssen Biotech Inc Receptores del antígeno quimérico anti-cd79, células car-t, y usos de estos.
EP4228682A4 (en) * 2020-10-16 2024-11-13 Senti Biosciences, Inc. Chimeric receptors and methods of use thereof
CN114685657B (zh) * 2020-12-31 2024-08-16 康诺亚生物医药科技（成都）有限公司 一种功能增强型抗体阻断剂的开发及其应用
WO2023114962A1 (en) * 2021-12-16 2023-06-22 Unm Rainforest Innovations Humanized non-opioid composition and therapies for pain management

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242216B1 (en) * 1997-11-14 2001-06-05 Abbott Laboratories Nucleic acids encoding a functional human purinoreceptor P2X2 and P2X4, and methods of production and use thereof
US20050074819A1 (en) * 2003-10-01 2005-04-07 Japan Health Sciences Foundation Screening method of drug for treatment of neuropathic pain
US20080287467A1 (en) * 2004-05-06 2008-11-20 Gen Tamura Therapeutic Agent for Respiratory Diseases

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Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
EP0272253A4 (en) 1986-03-07 1990-02-05 Massachusetts Inst Technology METHOD FOR IMPROVING GLYCOPROTE INSTABILITY.
AU600575B2 (en) 1987-03-18 1990-08-16 Sb2, Inc. Altered antibodies
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
US6030613A (en) 1995-01-17 2000-02-29 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of therapeutics
AUPP991199A0 (en) * 1999-04-21 1999-05-13 University Of Sydney, The Methods for diagnosing pre-cancerous and cancerous conditions
AUPR201500A0 (en) * 2000-12-11 2001-01-11 Biosceptre Pty Ltd Methods for identifying pre-neoplastic and neoplastic states in mammals
WO2010093061A1 (ja) 2009-02-16 2010-08-19 日本ケミファ株式会社 ジアゼピンジオン誘導体
UA118028C2 (uk) * 2013-04-03 2018-11-12 Рош Глікарт Аг Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242216B1 (en) * 1997-11-14 2001-06-05 Abbott Laboratories Nucleic acids encoding a functional human purinoreceptor P2X2 and P2X4, and methods of production and use thereof
US20050074819A1 (en) * 2003-10-01 2005-04-07 Japan Health Sciences Foundation Screening method of drug for treatment of neuropathic pain
US20080287467A1 (en) * 2004-05-06 2008-11-20 Gen Tamura Therapeutic Agent for Respiratory Diseases

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Makoto Tsuda et al., "P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury", NATURE, (2003), Vol.424, doi:doi:10.1038/nature01786, pages 778 - 783 *
Rebecca J.Gum et al., "P2X receptor antagonists for pain management:examination of binding and physicochemical properties", Purinergic Signalling, (2012), Vol.8,Suppl.1, pages 41 - 56 *

Also Published As

Publication number Publication date
BR112016025450A2 (pt) 2017-12-12
WO2015166105A2 (en) 2015-11-05
WO2015166105A3 (en) 2015-12-30
ES2899754T3 (es) 2022-03-14
CA2946669A1 (en) 2015-11-05
AU2015254558A1 (en) 2016-12-08
US10654926B2 (en) 2020-05-19
US20200247885A1 (en) 2020-08-06
EP3137501A2 (en) 2017-03-08
US20170166634A1 (en) 2017-06-15
EP4001310A2 (en) 2022-05-25
EP4001310A3 (en) 2022-08-10
EP3137501B1 (en) 2021-09-29
JP2017515473A (ja) 2017-06-15
JP2020018307A (ja) 2020-02-06

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