AU2015239736B2 - Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions - Google Patents

Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions Download PDF

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Publication number
AU2015239736B2
AU2015239736B2 AU2015239736A AU2015239736A AU2015239736B2 AU 2015239736 B2 AU2015239736 B2 AU 2015239736B2 AU 2015239736 A AU2015239736 A AU 2015239736A AU 2015239736 A AU2015239736 A AU 2015239736A AU 2015239736 B2 AU2015239736 B2 AU 2015239736B2
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AU
Australia
Prior art keywords
pharmaceutical composition
compound
buffer
biopterin
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2015239736A
Other languages
English (en)
Other versions
AU2015239736A1 (en
Inventor
Peter Scheurer
Reinhard Schinzel
Frank Tegtmeier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Verinos Operations GmbH
Original Assignee
Vasopharm GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vasopharm GmbH filed Critical Vasopharm GmbH
Publication of AU2015239736A1 publication Critical patent/AU2015239736A1/en
Application granted granted Critical
Publication of AU2015239736B2 publication Critical patent/AU2015239736B2/en
Priority to AU2020203880A priority Critical patent/AU2020203880B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AU2015239736A 2014-03-31 2015-03-30 Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions Active AU2015239736B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2020203880A AU2020203880B2 (en) 2014-03-31 2020-06-12 Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14162727.3 2014-03-31
EP14162727.3A EP2926805B1 (en) 2014-03-31 2014-03-31 Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions
PCT/EP2015/056824 WO2015150294A1 (en) 2014-03-31 2015-03-30 Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2020203880A Division AU2020203880B2 (en) 2014-03-31 2020-06-12 Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions

Publications (2)

Publication Number Publication Date
AU2015239736A1 AU2015239736A1 (en) 2016-08-11
AU2015239736B2 true AU2015239736B2 (en) 2020-03-26

Family

ID=50389975

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2015239736A Active AU2015239736B2 (en) 2014-03-31 2015-03-30 Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions
AU2020203880A Active AU2020203880B2 (en) 2014-03-31 2020-06-12 Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2020203880A Active AU2020203880B2 (en) 2014-03-31 2020-06-12 Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions

Country Status (28)

Country Link
US (6) US9895372B2 (enExample)
EP (2) EP2926805B1 (enExample)
JP (3) JP6552515B2 (enExample)
KR (1) KR102374500B1 (enExample)
CN (2) CN113521017A (enExample)
AU (2) AU2015239736B2 (enExample)
CA (1) CA2938267C (enExample)
CL (1) CL2016002463A1 (enExample)
CY (1) CY1117881T1 (enExample)
DK (1) DK2926805T3 (enExample)
ES (1) ES2586945T3 (enExample)
HR (1) HRP20160802T1 (enExample)
HU (1) HUE030221T2 (enExample)
IL (1) IL248090B (enExample)
MX (1) MX377919B (enExample)
MY (1) MY180844A (enExample)
PE (1) PE20161253A1 (enExample)
PH (1) PH12016501519A1 (enExample)
PL (1) PL2926805T3 (enExample)
PT (1) PT2926805T (enExample)
RS (1) RS54973B1 (enExample)
RU (1) RU2694368C2 (enExample)
SA (1) SA516371933B1 (enExample)
SG (1) SG11201606151SA (enExample)
SI (1) SI2926805T1 (enExample)
SM (1) SMT201600246B (enExample)
WO (1) WO2015150294A1 (enExample)
ZA (1) ZA201605271B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6382997B2 (ja) 2014-02-07 2018-08-29 エクセセーラ ファーマシューティカルズ インコーポレイテッド 治療用化合物および組成物
EP2926805B1 (en) 2014-03-31 2016-05-18 Vasopharm GmbH Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions
JP2016168783A (ja) * 2015-03-13 2016-09-23 株式会社東芝 記録装置、記録方法、及び記録媒体
US12171766B2 (en) 2021-12-03 2024-12-24 Verinos Operations Gmbh Methods of treating patients suffering from brain injury and methods of increasing the value of the extended Glasgow Outcome Scale of patients suffering from brain injury
WO2019046849A1 (en) * 2017-09-01 2019-03-07 Censa Pharmaceuticals Inc. PHARMACEUTICAL COMPOSITION COMPRISING SEPAPTERINE AND USES THEREOF
JP6565103B2 (ja) * 2017-09-06 2019-08-28 株式会社昭和冷凍プラント 香気成分含有水溶液を含む液状製品の製造方法
KR20220070477A (ko) * 2019-09-25 2022-05-31 피티씨 테라퓨틱스 엠피, 인크. 고페닐알라닌혈증 치료 방법
CA3235704A1 (en) 2021-12-03 2023-06-08 Verinos Operations Gmbh Methods of treating patients suffering from brain injury and methods of increasing the value of the extended glasgow outcome scale of patients suffering from brain injury
EP4539850A1 (en) 2022-05-06 2025-04-23 VeriNOS operations GmbH Methods of treating patients suffering from a disease condition or disorder that is associated with an increased glutamate level

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922713A (en) * 1997-06-26 1999-07-13 Werner; Ernst Inhibition of nitric oxide synthase
WO2004084906A1 (en) * 2003-03-25 2004-10-07 Vasopharm Biotech Gmbh Use of pteridine derivatives for the treatment of increased intracranial pressure, secondary ischemia, and disorders associated with an increased level of cytotoxic reactive oxygen species

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59703603D1 (de) 1997-10-06 2001-06-28 Ernst Werner Pteridinderivate als NO Synthase-Hemmer
US6803046B2 (en) * 2002-08-16 2004-10-12 Bracco International B.V. Sincalide formulations
JP2007536210A (ja) * 2003-11-17 2007-12-13 メルック・エプロバ・アクチエンゲゼルシヤフト （６ｒ）−ｌ−エリスロ−テトラヒドロビオプテリンジヒドロクロライドの結晶形
WO2005107759A1 (ja) * 2004-05-11 2005-11-17 Daiichi Asubo Pharma Co., Ltd. Ｂｈ４反応性高フェニルアラニン血症治療剤
SE0401826D0 (sv) 2004-07-09 2004-07-09 Trimble Ab Method of preparing a winding for an n-phase motor
EP2436379A1 (en) * 2004-11-17 2012-04-04 BioMarin Pharmaceutical Inc. Stable tablet formulation
EP1669355A1 (en) * 2004-12-02 2006-06-14 Vasopharm Biotech GmbH Aminotetrahydropteridines and processes for manufacture thereof
DK3461503T3 (da) * 2007-04-11 2022-02-14 Biomarin Pharm Inc Fremgangsmåder til indgivelse af tetrahydrobiopterin, associerede sammensætninger og målingsfremgangsmåder
EP2140731A2 (de) 2007-04-24 2010-01-06 Osram Gesellschaft mit Beschränkter Haftung Schaltungsanordnung zur zündung und zum betrieb einer entladungslampe
ES2736730T3 (es) * 2008-08-12 2020-01-07 Orpha Swiss Gmbh Forma de administración farmacéutica que contiene tetrahidrobiopterina
EP2680848A4 (en) * 2011-03-01 2014-11-05 Rubicon Res Private Ltd STABLE TETRAHYDROBIOPTERINE COMPOSITIONS
US9006289B2 (en) * 2011-08-30 2015-04-14 Fresenius Kabi Usa, Llc Levothyroxine formulations
EP2926805B1 (en) * 2014-03-31 2016-05-18 Vasopharm GmbH Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922713A (en) * 1997-06-26 1999-07-13 Werner; Ernst Inhibition of nitric oxide synthase
WO2004084906A1 (en) * 2003-03-25 2004-10-07 Vasopharm Biotech Gmbh Use of pteridine derivatives for the treatment of increased intracranial pressure, secondary ischemia, and disorders associated with an increased level of cytotoxic reactive oxygen species

Also Published As

Publication number Publication date
JP7178731B2 (ja) 2022-11-28
BR112016020101A8 (pt) 2021-06-29
BR112016020101A2 (enExample) 2017-07-15
US20230355630A1 (en) 2023-11-09
KR20160138406A (ko) 2016-12-05
JP2021105062A (ja) 2021-07-26
EP2926805A1 (en) 2015-10-07
HK1213195A1 (en) 2016-06-30
ES2586945T3 (es) 2016-10-19
ZA201605271B (en) 2017-08-30
CY1117881T1 (el) 2018-03-07
PL2926805T3 (pl) 2016-12-30
HUE030221T2 (en) 2017-04-28
AU2020203880A1 (en) 2020-07-02
MX2016012784A (es) 2017-04-25
US20210137927A1 (en) 2021-05-13
CA2938267C (en) 2023-05-09
PT2926805T (pt) 2016-07-15
SMT201600246B (it) 2016-08-31
AU2020203880B2 (en) 2022-03-31
IL248090B (en) 2019-10-31
IL248090A0 (en) 2016-11-30
US10925877B2 (en) 2021-02-23
EP3125864A1 (en) 2017-02-08
NZ722455A (en) 2022-03-25
PH12016501519B1 (en) 2017-02-06
CN113521017A (zh) 2021-10-22
US9895372B2 (en) 2018-02-20
SG11201606151SA (en) 2016-08-30
DK2926805T3 (en) 2016-07-25
MX377919B (es) 2025-03-10
RU2694368C2 (ru) 2019-07-12
US11717522B2 (en) 2023-08-08
KR102374500B1 (ko) 2022-03-15
RS54973B1 (sr) 2016-11-30
JP2019194227A (ja) 2019-11-07
RU2016141449A3 (enExample) 2018-12-14
US10016431B2 (en) 2018-07-10
MY180844A (en) 2020-12-10
US20200046710A1 (en) 2020-02-13
WO2015150294A1 (en) 2015-10-08
US20220031703A9 (en) 2022-02-03
JP6879582B2 (ja) 2021-06-02
US20170296543A1 (en) 2017-10-19
PE20161253A1 (es) 2016-11-13
PH12016501519A1 (en) 2017-02-06
US20170112836A1 (en) 2017-04-27
JP6552515B2 (ja) 2019-07-31
US12458644B2 (en) 2025-11-04
SI2926805T1 (sl) 2016-09-30
RU2016141449A (ru) 2018-05-07
CL2016002463A1 (es) 2017-01-27
HRP20160802T1 (hr) 2016-08-12
US10493075B2 (en) 2019-12-03
SA516371933B1 (ar) 2019-04-14
JP2017509623A (ja) 2017-04-06
CA2938267A1 (en) 2015-10-08
EP2926805B1 (en) 2016-05-18
AU2015239736A1 (en) 2016-08-11
US20180289714A1 (en) 2018-10-11
CN106572976A (zh) 2017-04-19

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